Browse by Phase
Phase 1 / Phase 2 Clinical Trials
Phase 1/2 combined trials evaluate both safety (Phase 1) and preliminary efficacy (Phase 2) in a single study protocol, often used to accelerate early development.
Total Trials
361
Recruiting Now
361
Top Conditions in Phase 1 / Phase 2
NCT07174583 Phase 1, Phase 2
Recruiting
A Study of IDE849 in Patients With DLL3 Expressing Tumors Including Small Cell L...
Condition
Small-cell Lung Cancer
Enrollment
208 pts
Location
United States, Australia, Brazil
Sponsor
IDEAYA Biosciences
NCT05734066 Phase 1, Phase 2
Recruiting
Study of Lurbinectedin Monotherapy in Pediatric and Young Adult Participants Wit...
Condition
Refractory Ewing Sarcoma
Enrollment
60 pts
Location
United States, Canada
Sponsor
Jazz Pharmaceuticals
NCT05410145 Phase 1, Phase 2
Recruiting
A Study of D3S-001 Monotherapy or Combination Therapy in Subjects With Advanced ...
Condition
KRAS P.G12C
Enrollment
442 pts
Location
United States, Australia, China
Sponsor
D3 Bio (Wuxi) Co., Ltd
NCT02638701 Phase 1, Phase 2
Recruiting
Infliximab Therapy for Dolichoectactic Vertebrobasilar Aneurysms
Condition
Aneurysm
Enrollment
8 pts
Location
United States
Sponsor
University of California, San
NCT05905328 Phase 1, Phase 2
Recruiting
Study of CTO1681 for the Prevention and Treatment of CRS in DLBCL Patients Recei...
Condition
Cytokine Release Syndrome
Enrollment
54 pts
Location
United States
Sponsor
CytoAgents, Inc.
NCT05270200 Phase 1, Phase 2
Recruiting
Single Arm Study of Post-transplant Azacitidine and Chidamide for Prevention of ...
Condition
Leukemia, Myeloid, Acute
Enrollment
20 pts
Location
China
Sponsor
Zhujiang Hospital
NCT06938880 Phase 1, Phase 2
Recruiting
Study of ZGGS18 in Combination With ZG005 in Patients With Advanced Solid Tumors
Condition
Advanced Solid Tumor
Enrollment
60 pts
Location
China
Sponsor
Suzhou Zelgen Biopharmaceutica
NCT06159166 Phase 1, Phase 2
Recruiting
Mirdametinib Monotherapy in Adults With Neurofibromatosis 1 (NF1) and Cutaneous ...
Condition
NF1
Enrollment
24 pts
Location
United States
Sponsor
Johns Hopkins University
NCT07128381 Phase 1, Phase 2
Recruiting
Phase I/II Clinical Trial of Axatilimab, a CSF1R Monoclonal Antibody, in Combina...
Condition
Myelofibrosis (MF)
Enrollment
66 pts
Location
United States
Sponsor
M.D. Anderson Cancer Center
NCT07036003 Phase 1, Phase 2
Recruiting
Recombinant Human Growth Hormone (rHGH) for Knee Osteoarthritis (KORR)
Condition
Knee Osteoarthritis (Knee OA)
Enrollment
34 pts
Location
Canada
Sponsor
Dr. David Wasserstein
NCT05804669 Phase 1, Phase 2
Recruiting
A Study to Evaluate the Safety and PK of CRN04894 for the Treatment of Cushing's...
Condition
Cushing Syndrome
Enrollment
18 pts
Location
United States
Sponsor
Crinetics Pharmaceuticals Inc.
NCT07206056 Phase 1, Phase 2
Recruiting
An Open-label Dose Escalation and Expansion, Followed by a Phase II Study of Tul...
Condition
Progressive Metastatic Castrate Resistant Prostate Cancer
Enrollment
188 pts
Location
United States, Australia, China
Sponsor
Novartis Pharmaceuticals
NCT06832722 Phase 1, Phase 2
Recruiting
Procizumab (PCZ; AK1967) in Critical Cardiovascular Care
Condition
Shock, Cardiogenic
Enrollment
130 pts
Location
Belgium, Czechia, France
Sponsor
4TEEN4 Pharmaceuticals GmbH
NCT06678113 Phase 1, Phase 2
Recruiting
Study to Assess the Safety and Efficacy of Intravenous BSG005 in Patients With I...
Condition
Invasive Fungal Infection
Enrollment
15 pts
Location
India
Sponsor
Biosergen AS
NCT07008703 Phase 1, Phase 2
Recruiting
Phase I Study of sss40 Injection for Moderate-to-Severe Bone Metastatic Cancer P...
Condition
Cancer Pain
Enrollment
132 pts
Location
China
Sponsor
Shenyang Sunshine Pharmaceutic
NCT04683653 Phase 1, Phase 2
Recruiting
Study of Pelvic Hypofractionated Radiotherapy in Endometrial Cancer
Condition
Endometrial Cancer
Enrollment
100 pts
Location
United States
Sponsor
University of Chicago
NCT06090227 Phase 1, Phase 2
Recruiting
AMPK-activation by Metformin in FSGS: AMP-FSGS
Condition
Focal Segmental Glomerulosclerosis
Enrollment
30 pts
Location
United States
Sponsor
Yale University
NCT07096453 Phase 1, Phase 2
Recruiting
CMVIG Prophylaxis in Belatacept Conversion Kidney Transplant Recipients
Condition
Kidney Transplant; Complications
Enrollment
30 pts
Location
United States
Sponsor
University of Minnesota
NCT04390737 Phase 1, Phase 2
Recruiting
Evaluate the Safety and Clinical Activity of HH2853
Condition
FL Lymphoma
Enrollment
254 pts
Location
United States, China
Sponsor
Haihe Biopharma Co., Ltd.
NCT05852145 Phase 1, Phase 2
Recruiting
Oral Changes With Caloric and no Caloric Sweeteners
Condition
pH
Enrollment
52 pts
Location
Mexico
Sponsor
Hospital Infantil de Mexico Fe
NCT05849662 Phase 1, Phase 2
Recruiting
A Phase I/II Study of Trametinib and Azacitidine for Patients With Newly Diagnos...
Condition
Leukemia, Juvenile Myelomonocytic
Enrollment
58 pts
Location
United States
Sponsor
Therapeutic Advances in Childh
NCT04989803 Phase 1, Phase 2
Recruiting
Study of KITE-363 or KITE-753 in Participants With Relapsed and/or Refractory B-...
Condition
Relapsed and/or Refractory B-cell Lymphoma
Enrollment
247 pts
Location
United States, Australia, Germany
Sponsor
Kite, A Gilead Company
NCT06422923 Phase 1, Phase 2
Recruiting
A Phase 1/2 Study of NRTX-1001 Neuronal Cell Therapy in Drug-Resistant Bilateral...
Condition
Epilepsy, Temporal Lobe
Enrollment
10 pts
Location
United States
Sponsor
Neurona Therapeutics
NCT03161223 Phase 1, Phase 2
Recruiting
Durvalumab in Different Combinations With Pralatrexate, Romidepsin and Oral 5-Az...
Condition
Lymphoma, T-Cell
Enrollment
148 pts
Location
United States
Sponsor
University of Virginia
NCT06572605 Phase 1, Phase 2
Recruiting
External Beam Radiation Therapy in Combination With Talquetamab for the Treatmen...
Condition
Extramedullary Disease in Multiple Myeloma
Enrollment
20 pts
Location
United States
Sponsor
City of Hope Medical Center