To join a pain clinical trial in United States, select a recruiting trial below and check the eligibility criteria. Contact the trial's principal investigator or the listed site in United States directly. All trials listed here are sourced from ClinicalTrials.gov, the official U.S. registry of clinical studies.

What phases are pain trials in United States?

Active pain trials in United States span EARLY_Phase 1, Phase 2, Phase 4. Phase I trials test safety, Phase II test efficacy, and Phase III compare against standard treatments in larger patient populations.

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ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer · Last Reviewed: September 2026 · Data Methodology

Active Trials in United States (20)

State of Hormones Impact Nociceptive Expression

Registry of Outcomes of Dezawa MuseCells®

Pain Control and Quality of Recovery After Intravenous Methadone Versus Intravenous Remifentanil in Craniotomy Surgery

Transdiagnostic Cognitive Biomarkers

Feasibility Study of a Guided Imagery Therapy Mobile Application for Functional Abdominal Pain Disorders in Children

Mechanisms of Cannabidiol in Persons With MS: the Role of Sleep and Pain Phenotype

Pain With Dementia

Training in Evidence-based Treatments in Psycho-Oncology

Hip Arthroscopy Postoperative Opioid Demands

Pain Intervention With Needling: Pilot Of Integrated Neuromodulation Techniques

Low-dose Buccal Buprenorphine: Relative Abuse Potential and Analgesia

Sociocultural & Biobehavioral Influences on Pain Expression and Assessment

Neural Mechanisms of Immersive Virtual Reality in Chronic Pain (VR TMD EEG)

Pivotal Study on the NOVABLOC System for Patients Undergoing Primary Total Knee Arthroplasty

Spatiotemporal Thalamocortical Alterations Underlie Experimental and Chronic Pain

Optimizing Pain Control in Transurethral Resection of the Prostate

Remimazolam NeuroImaging

Evaluation of Pain Treatment After Total Knee Arthroplasty

Pervasive Sensing and AI in Intelligent ICU

Pain in Aging Former Athletes, Master's Athletes, and Nonathletes

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