Mechanisms of Cannabidiol in Persons With MS: the Role of Sleep and Pain Phenotype
Trial Parameters
Brief Summary
The purpose of this research study is to compare the effects of cannabidiol (CBD), tetrahydrocannabinol (THC), or both, on sleep and pain in persons with multiple sclerosis (MS). Little is known about how CBD and/or THC may help sleep, reduce pain, or perhaps even treat pain through better sleep.
Eligibility Criteria
Inclusion Criteria: 1. Patients with clinically definite MS (those who are on a disease modifying therapy must be on a stable dose without evidence of liver toxicity for at least 3 months); 2. Presence of chronic pain defined as moderate to severe pain for at least 3 months, based on a 0-10 numeric rating scale (NRS); 3. Willingness to maintain stable analgesic regimen during study period; 4. Recent serum aspartate transaminase, alanine transaminase, and bilirubin testing within 90 days of screening; Exclusion Criteria: 1. Current shift work sleep disorder, or narcolepsy diagnosed with polysomnography and multiple sleep latency test; 2. History of MS relapse within the last 30 days prior to screening (participants will be considered eligible after the 30-day window); 3. Pain due to cancer; 4. Pregnancy or breastfeeding; 5. Current cannabinoid use (participants may be reconsidered for inclusion after 30-day washout) and/or unwillingness to abstain from cannabinoids in any form from 30 d