To join a obesity clinical trial in United States, select a recruiting trial below and check the eligibility criteria. Contact the trial's principal investigator or the listed site in United States directly. All trials listed here are sourced from ClinicalTrials.gov, the official U.S. registry of clinical studies.

What phases are obesity trials in United States?

Active obesity trials in United States span EARLY_Phase 1, Phase 1, Phase 1, Phase 2, Phase 3, Phase 4, Phase 2. Phase I trials test safety, Phase II test efficacy, and Phase III compare against standard treatments in larger patient populations.

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ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer · Last Reviewed: November 2026 · Data Methodology

Active Trials in United States (46)

Regional Lipolysis Insulin Regulation

Glucagon-like Peptide 1 (GLP-1) Receptor Agonist Therapy and Exercise Training in People With Obesity

A Clinical Study of Semaglutide Nasal Spray in Overweight or Obese Adults

Mechanistic and Clinical Outcomes of a Surgical Innovation Aimed at Minimizing GERD Associated With VSG (INNOVATE-VSG)

A Culturally-relevant Micronutrient-dense Plant-rich (mNDPR) Dietary Intervention for Native Americans

DNA Methylation and Vascular Function

Metabolic Adaptations to Weight Loss With and Without Exercise

A Study to Investigate Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of AZD1043 in Healthy Adult Participants Living With Overweight and/or Obesity.

First-in-human Study of the Safety, Tolerability, Pharmacokinetics, and Food Effect of ACCG-2671

A Novel Digital Tool Clinicians Can Use to Prescribe Exercise to Patients With Cardiovascular Disease Risk Factors

GENESIS: Genotype Guided - Natriuretic Peptides - Cardiometabolic Health Study

Small Extracellular Vesicles and Insulin Action

AMAZE 4: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Obstructive Sleep Apnoea Treated With Positive Airway Pressure Lose Weight and Improve Sleep Apnoea

A Study to Learn About Berobenatide Given Once Weekly in Adults With Knee Osteoarthritis and Overweight or Obesity With or Without Type 2 Diabetes (VESPER-OA 2)

Personalized Responses to Dietary Composition Trial 3

AMAZE 1: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight Lose Weight

Exercise Training and Fat Metabolism in Postmenopausal Women

Lifestyle Medicine: Establishing Clinical Approaches to Chronic Disease for Rural Patients

Endoscopic Sleeve Gastroplasty (ESG) for the Treatment of Obesity

Pharmacotherapy in Conjunction With Lifestyle Counseling for Management of Weight Regain After Bariatric Surgery

Modifying Adiposity Through Behavioral Strategies to Improve COVID-19 Rehabilitation

Insulin Regulation of Lipolysis and Lipolysis Proteins

Partnership to Reduce Obesity in Community Health Center Patients (SMARTLife Utah)

Bone Metabolism in 12-21 Year Olds Undergoing Glucagon Like Peptide (GLP)-1 Receptor Agonist Therapy

Maridebart Cafraglutide in Heart Failure With Preserved or Mildly Reduced Ejection Fraction and Obesity

Weight Loss Through Mayo Clinic Diet

Alzheimer"s Imaging Biomarkers in Obesity

Interscalene vs Phrenic-sparing Blocks in Obesity and Effect of Maximum Inspiratory Pressure

Extension Trial to Evaluate the Long-term Efficacy, Safety, and Tolerability of Maridebart Cafraglutide (MARITIME-2-EXTENSION)

Ketogenic Diets for Weight Loss Maintenance: Impact on Energy Expenditure and Appetite in Individuals With Obesity

Family COMIDA (Consumo de Opciones Más Ideales De Alimentos) (Eating More Ideal Food Options)

A Study to Investigate Weight Management With Macupatide and Eloralintide, Alone or in Combination, in Adult Participants With Obesity or Overweight

Sympathetic Transduction in Obesity-associated Hypertension (OB-HTN)

Optimization of Chrononutrition to Reduce the Risk of Disease in Shift Workers

Regional Lipolysis and Adipocyte Lipolysis Protein Stimulation

Facilitated Transitions From Postpartum to Primary Care Coordination for People With Chronic Conditions

Individualized Pharmacological Approach to Obesity in Patients With Bipolar Disorder

Collaborative Multi-level Obesity Intervention Engaging Communities Trial

Vibegron for ENergy Thinking and Resilience in Aging

Predictors of Behavioral Obesity Treatment Outcomes

Heart Health Study in Washington D.C. to Develop a Community-Based Behavioral Weight Loss Intervention

Validation of a Novel Cerebellar-striatal Satiety Circuit in Humans

TIRzepatide for the Treatment of Obesity in Patients With Atrial Fibrillation

A Study to See if an iPhone Weight Management App Can Help Promote Weight Loss in Adolescents and Young Adults After a Stem Cell Transplant

Effect of Tirzepatide on Markers of MASLD in Patients With Obesity

A Research Study Investigating How Adults With Overweight or Obesity, With or Without Type 2 Diabetes, Tolerate Switching to a New Treatment (Zenagamtide) From Their Current Tirzepatide Medication

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