To join a obesity clinical trial in United States, select a recruiting trial below and check the eligibility criteria. Contact the trial's principal investigator or the listed site in United States directly. All trials listed here are sourced from ClinicalTrials.gov, the official U.S. registry of clinical studies.

What phases are obesity trials in United States?

Active obesity trials in United States span Phase 3, EARLY_Phase 1, Phase 1, Phase 2, Phase 4, Phase 1, Phase 2. Phase I trials test safety, Phase II test efficacy, and Phase III compare against standard treatments in larger patient populations.

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ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer · Last Reviewed: July 2026 · Data Methodology

Active Trials in United States (43)

AMAZE 12: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight Maintain Their Weight Loss

RESET System Pivotal Trial (Rev F)

SMARTer Weight Loss Management

A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Knee Osteoarthritis Lose Weight and Reduce Pain

Ketogenic Diets for Weight Loss Maintenance: Impact on Energy Expenditure and Appetite in Individuals With Obesity

EBT Fruit and Vegetable Prescription

Collaborative Multi-level Obesity Intervention Engaging Underserved Communities Trial

Sleep and Metabolism

Harnessing Macrophage Lysosomal Lipid Metabolism in Obesity (ATM)

Inspire HER: Inspiring the Heart and Emotions for Radical Health

Effect of Tirzepatide on Markers of MASLD in Patients With Obesity

Health Promotion With Targeted Exercise Intervention for Decreasing Fall Risk and Inactivity in Aging Veterans With Obesity and Signs of Sarcopenia

Diazoxide Suppression Test P&F Study

Characterization of Patients With Uncommon Presentations and/or Uncommon Diseases Associated With the Cardiovascular System

Addressing Diabetes by Elevating Access to Nutrition

Cognitive Strategies for Weight Loss

PRImary Care Strategies for Weight Management (PRISM) Study

Ketogenic Diet and Diabetes Demonstration Project

Milk-Tot Study: Impact of Whole Versus Low-fat Milk on Child Health

Endoscopic Sleeve Gastroplasty (ESG) for the Treatment of Obesity

Efficacy of Using Mobile Health Applications for Health

Transduction of Sympathetic Neural Activity in Human Obesity Without Hypertension

Evaluation of the Tolerability of Cagrilintide in Participants Not Tolerating GLP-1-RA Therapies Due to Gastrointestinal Adverse Events

The Path to Optimal Black Maternal Heart Health: Comparing Two CVD Risk Reduction Interventions (Change of HEART)

Evaluation of Milk Polar Lipids in Dyslipidemic Adults With Abdominal Obesity

Growth Hormone Resistance of Beta-cells A

Arterial Destiffening Effects of SGLT2 Inhibition in Veterans With Obesity

The Effects of an Obesogenic Lifestyle in Recreationally Active, Young Adults

Preparing FIM-BCS - A Lifestyle Modification for African-American Breast Cancer Survivors

Tailoring Mobile Health Technology to Reduce Obesity and Improve Cardiovascular Health in Resource-Limited Neighborhood Environments

Taxi ROADmAP (Realizing Optimization Around Diet And Physical Activity)

Understanding Metabolism and Inflammation Risks for Diabetes in Adolescents

Physiologic Markers of Cardiometabolic Risk in People With Type 1 Diabetes

A Research Study on How Well Cagrilintide and CagriSema Work in Children and Adolescents With Excess Body Weight

PreventT2 Together: Examining the Efficacy of Couple-based Lifestyle Intervention to Prevent Type 2 Diabetes

Heart Health Study in Washington D.C. to Develop a Community-Based Behavioral Weight Loss Intervention

The Effects of Mirabegron and Tadalafil on Glucose Tolerance in Prediabetics

Concurrent Laparoscopic Hysterectomy and Weight Loss Surgery in Obese Patients With Endometrial Carcinoma or Endometrial Intraepithelial Neoplasia

GLP-1R Actions on Muscle and the Skeleton

A Study of Eloralintide (LY3841136) in Participants With Obesity, or Overweight Without Type 2 Diabetes

Project SHINE (Sleep Health INitiative for Equity): Culturally Informing a Sleep Extension Intervention for African American Adults

Research Framework Exploring Sleep Health

Understanding and Addressing Risks of Low Socioeconomic Status and Diabetes for Heart Failure

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