To join a obesity clinical trial in United States, select a recruiting trial below and check the eligibility criteria. Contact the trial's principal investigator or the listed site in United States directly. All trials listed here are sourced from ClinicalTrials.gov, the official U.S. registry of clinical studies.

What phases are obesity trials in United States?

Active obesity trials in United States span Phase 1, Phase 3, Phase 2, EARLY_Phase 1, Phase 4. Phase I trials test safety, Phase II test efficacy, and Phase III compare against standard treatments in larger patient populations.

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ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer · Last Reviewed: September 2026 · Data Methodology

Active Trials in United States (45)

Diet Order Effects of Low Fat vs. Low Carb Diets on Body Fat Change

Mitigating the Pro-inflammatory Phenotype of Obesity

Examination of How the Duration of Fasting and Temporary Stopping of GLP-1 Medications Affect the Amount of Food Left in the Stomach in People Using Liraglutide (Injected), Semaglutide (Taken by Mouth) or Semaglutide (Injected)

Exercise Effects on Adipose Tissue Structure and Function

Brain Blood Flow and Lactate in Non-obese and Obese Subjects

A Study to Evaluate Tradipitant on Treating Nausea and Vomiting Induced by GLP-1R Agonist Use

Heart Health Study in Washington D.C. to Develop a Community-Based Behavioral Weight Loss Intervention

Cannabis for Obesity Trial

Exercise, Brain Activity, and Weight Maintenance

International Weight Control Registry

Extension Trial to Evaluate the Long-term Efficacy, Safety, and Tolerability of Maridebart Cafraglutide (MARITIME-1-EXTENSION)

Concentration of n-3 PUFA Monohydroxylated Derivatives in Adults With Obesity After n-3 PUFA Supplementation.

Efficacy and Safety of Endoscopic Antral Myotomy as a Novel Weight Loss Procedure

Extracellular Vesicles, Insulin Action, and Exercise

Mechanisms Underlying Individual Variations of Taste and Smell in Obesity

Effect of Insulin Lowering on Lipogenesis

The Gut Microbiome in Type 1 Diabetes and Mechanism of Metformin Action

HIIT Effects on Cardiometabolic Health

Scalable TELeheaLth Cancer CARe: The STELLAR Program to Treat Cancer Risk Behaviors

Body Composition Related Evaluation of Airway Tone and Hyper-rEactivity Using Oscillometry

Fundus Ablation Registry (Gastric Fundus Mucosal Ablation for Weight Loss)

A Platform Trial for Pediatric Participants With Obesity or Overweight (LY900040)

Exercise Training and Fat Metabolism in Postmenopausal Women

Resistance Exercise and Incretin Mimetic for Cardiometabolic Health in Survivors of ALL With Obesity

Semaglutide for Post-Smoking Cessation Weight Management

Arterial Destiffening Effects of SGLT2 Inhibition in Veterans With Obesity

Effects of Obesity in the Aged

SMARTer Weight Loss Management

Conical Forearm and Cylindrical Upper Arm Non-Invasive Blood Pressure (NIBP) Measurements in Pregnant Patients

A Study of Once-daily Oral ASC30 to Evaluate the Efficacy and Safety in Adult Participants With Obesity or Overweight With Type 2 Diabetes

Inspire HER: Inspiring the Heart and Emotions for Radical Health

Redefining BMI: The Body, Mind, and Inflammation Trial

Sympathetic Transduction in Obesity-associated Hypertension (OB-HTN)

A Study to Investigate Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of AZD1043 in Healthy Adult Participants Living With Overweight and/or Obesity.

Spinal Cord Injury Model Systems (SCIMS) - Education Module

Experimental Approach to Test Predictions of Body Weight Regulation Models

The Physiology of Human Brown Adipose Tissue

Testing an Integrated PTSD and Weight Management Intervention: A Hybrid Type 1 Trial

Understanding and Addressing Risks of Low Socioeconomic Status and Diabetes for Heart Failure

A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Knee Osteoarthritis Lose Weight and Reduce Pain

The Effects of Metabolic & Bariatric Surgery on Lipid Metabolism, Myeloid-Derived Suppressor Cells, and Cancer Cell Biology

GLP-1R Actions on Muscle and the Skeleton

A Study to Improve Skeletal Muscle in Veterans With HIV

The Effect of Tirzepatide on Menopausal Vasomotor Symptoms and Biological Aging in Post-menopausal Women With Obesity

HealthyTogether: RCT of a Dyadic Weight Management Intervention

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