NCT05880108 Modifying Adiposity Through Behavioral Strategies to Improve COVID-19 Rehabilitation
| NCT ID | NCT05880108 |
| Status | Recruiting |
| Phase | — |
| Sponsor | VA Office of Research and Development |
| Condition | Post-COVID Conditions |
| Study Type | INTERVENTIONAL |
| Enrollment | 150 participants |
| Start Date | 2024-06-03 |
| Primary Completion | 2029-09-30 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 150 participants in total. It began in 2024-06-03 with a primary completion date of 2029-09-30.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
The research in this VA Merit will examine the effects of obesity and Post-COVID Conditions (PCC) on physical functioning, health-related quality of life, and adipose tissue inflammatory and cellular senescence profiles in older Veterans. Further, it will evaluate whether a weight loss intervention, including dietary modification and exercise, in obese Veterans with and without PCC will reduce systemic and adipose tissue inflammation and senescence and promote PCC recovery.
Eligibility Criteria
Inclusion Criteria: 1. U.S. Veteran 2. Self-reported COVID-19 naïve or COVID-19 \> 90 days ago for lean and obese PCC naïve or documented COVID-19 for the lean and obese PCC groups (At least one PCC symptom \>4 weeks) 3. Body Mass Index: 19-25 or 30-50 kg/m2 Exclusion Criteria: 1. Neurologic, musculoskeletal, or other condition that limits subject's ability to complete study physical assessments 2. Active inflammatory, COVID-19, autoimmune, infectious, hepatic (LFTs \> 2.5 x WNL), renal (eGFR\<45), gastrointestinal, malignant, and psychiatric disease 3. Uncontrolled diabetes (HbA1c \>10% or the current use of insulin) 4. Weight change within the past month of \>5 kg 5. Self-reported alcohol or drug abuse 6. Anti-coagulant medication usage
Contact & Investigator
Alice S. Ryan, PhD
PRINCIPAL INVESTIGATOR
Baltimore VA Medical Center VA Maryland Health Care System, Baltimore, MD
Frequently Asked Questions
Who can join the NCT05880108 clinical trial?
This trial is open to participants of all sexes, up to 80 Years, studying Post-COVID Conditions. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT05880108 currently recruiting?
Yes, NCT05880108 is actively recruiting participants. Contact the research team at kristina.marcus@va.gov for enrollment information.
Where is the NCT05880108 trial being conducted?
This trial is being conducted at Baltimore, United States, San Antonio, United States.
Who is sponsoring the NCT05880108 clinical trial?
NCT05880108 is sponsored by VA Office of Research and Development. The principal investigator is Alice S. Ryan, PhD at Baltimore VA Medical Center VA Maryland Health Care System, Baltimore, MD. The trial plans to enroll 150 participants.
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