Medical Condition

anxiety

Total Trials

52

Recruiting Now

52

Trial Phases

EARLY_Phase 1, Phase 2

Anxiety disorders — including generalized anxiety disorder (GAD), social anxiety disorder, PTSD, panic disorder, and OCD — collectively represent the most prevalent psychiatric condition globally, affecting approximately 30% of adults at some point in their lives. Despite widespread availability of SSRIs, SNRIs, and benzodiazepines, substantial proportions of patients fail to achieve remission, driving an active clinical trial landscape for novel mechanisms and delivery formats.

Active trials investigate CRHR1 antagonists for stress-induced anxiety, V1b vasopressin receptor antagonists, cannabidiol formulations, MDMA-assisted psychotherapy for PTSD (Phase 3 results showed strong efficacy in two trials), ketamine infusion for severe GAD refractory to other treatments, transcranial magnetic stimulation (TMS), and digital therapeutics combining cognitive behavioral therapy with biometric monitoring. PTSD trials often recruit veterans and first responders.

Anxiety trials typically use validated rating scales (HAM-A, GADARS, CAPS-5 for PTSD) at baseline and follow-up; prior SSRIs/SNRIs trials and current benzodiazepine use are common eligibility considerations.

Frequently Asked Questions — anxiety Clinical Trials

How many clinical trials are currently recruiting for anxiety?

ClinicalMetric currently tracks 52 actively recruiting clinical trials for anxiety, sourced in real time from ClinicalTrials.gov. The total number of registered studies—including those not yet enrolling or in active follow-up—is 52. Trial availability changes daily as new studies open enrollment and existing ones reach capacity.

What trial phases are available for anxiety?

anxiety research spans Phase 1 (1 trial), Phase 2 (3 trials). Phase 1 studies evaluate safety and dosing in small groups, Phase 2 studies assess preliminary efficacy in 100–300 participants, and Phase 3 trials compare the new treatment against the standard of care in 300–3,000+ patients. Phase 4 post-approval studies monitor long-term outcomes in real-world populations.

How do I find out if I qualify for a anxiety clinical trial?

Eligibility criteria for anxiety trials vary by study and typically specify age range, disease stage or severity, prior treatment history, and specific diagnostic or laboratory parameters. Each listing on ClinicalMetric links to the full protocol on ClinicalTrials.gov, where inclusion and exclusion criteria are documented. Contact the sponsoring site's research coordinator directly to confirm your eligibility—your treating physician or specialist can also help identify the most appropriate trial based on your medical history and current treatment status.

Trial Phases

Phase 1

Phase 2

Top Sponsors

University of Miami 2 trials

Babes-Bolyai University 2 trials

University of California, Los Angeles 2 trials

Yale University 1 trial

University of Aarhus 1 trial

anxiety

Frequently Asked Questions — anxiety Clinical Trials

Recruiting Clinical Trials

Assessing the Effectiveness of Digital Wellness Modules on Perceived Quality of Life

Combining Treatment Components in Transdiagnostic Therapy for Anxiety and Depression

Effect of Music and Warm Foot Bath Therapy on Pregnancy-Related Anxiety, Blood Pressure and Quality of Life

Radiotherapy Patient Education With Virtual Reality

Contribution of Hypnosis on Image Quality in Cardiac MRI

AI Avatar Video vs. Tell-Show-Do for Reducing Anxiety and Improving Cooperation in Children During Local Anesthesia

Role of Parent Interpretation Bias in the Transmission of Anxiety to Children

Influence of Preoperative Fear on Pain and Postoperative Outcomes

Improving Emotional Wellbeing of University Students: Anxiety Management

Impact of Nut Consumption on Mental Health in Young Adults

The Relationship Between Quality of Life, Anxiety Levels, and Attitudes Toward Artificial Intelligence Among Women Undergoing Infertility Treatment

Death Anxiety, Depression and Anxiety: An Experimental Study

The Effect of Stress Ball Intervention During Non-Stress Test on Anxiety and Fetal Well-Being in High-Risk Pregnancy

Assessing the Impact of Therapeutic Communication on Patients' Anxiety During Elective Cesarean Sections

The Effects of Daily Polyvagal Exercises on Stress in Students of Physical Therapy

Personalized Feedback Intervention for Latinx Drinkers With Anxiety

A Behavioral mHealth Intervention for People With HIV With Anxiety and Depression

Neuromodulation of Brain and Emotional Responses to Psychological Stress

Virtual Reality in Elective Caesarean Births Study (VREC)

Mobile App for Latinx Hazardous Drinkers With Clinical Anxiety

Sleep, Dreaming, and Virtual Reality for Mental Health

Mind-body Resilience Program for Cardiac Arrest Survivors and Their Caregivers: Recovering Together After Cardiac Arrest

VIrtual Reality Induced Pain and anxiEty Relief in Outpatient UROlogical Procedures

Adverse Adolescent Pathways to Substance Use

Can Cognitive Therapy Rating Scale (CTRS) be Used Across Cultures? Enhancing Cultural Relevance of CTRS

Intervention to Enhance Coping and Help-seeking Among Youth in Foster Care

The Effect of Music on Anxiety and Vasospasm in Patients Undergoing Transradial Angiography

Feasibility and Acceptability of an E-learning Dialectical Behavior Therapy Skills Course

Adaptive Coping Skills Training to Improve Psychological Distress Among Cardiorespiratory Failure Survivors

Personalized Brain Stimulation to Treat Chronic Concussive Symptoms

Music Therapy's Impact on University Students' Social and Mental Health

The Social Regulation of Threat-related Vigilance and Arousal

Effect of Informing Family Members of Patients During Surgery

Brief Trial of ACT-i for Adults With Chronic Insomnia

Virtual Reality vs. Music Relaxation for Reducing Anxiety and Pain During Breast Biopsies

Pramipexole to Enhance Social Connections

Esketamine Nasal Spray in Real-World Settings in Treatment-Resistant Depression

Effectiveness of a Guided Mobile App Intervention for Depression and Anxiety in University Students (PROMES-U Study)

Cannabidiol and Older Adult Cannabis Users

The BEAR Program for Women With Trauma Who Have Suicidal Thoughts

Collaborative Care for Treatment of Depression and Anxiety

Health Surveillance at Constructor University Bremen (CUB) and Among HAW-Hamburg Employees

S.T.A.N.D. Alacrity Center Signature Project

CBT and the Neural Circuits of Anxiety

The Effects of Low-Intensity Music in Adolescents With Anxiety

Binaural Beats for Postoperative Pain and Anxiety Reduction

A Precision Medicine Approach to Target Engagement for Emotion Regulation

Virtual Patient Groups for Sarcoidosis Associated Fatigue

Video Game Play to Alleviate Adolescent Anxiety

Mixed-method Research Protocol: Evaluation of a Relaxation Technique for Anxiety Management in Pre-surgical Pediatric Patients

Pilot Study of Virtual Reality Therapy for Students With Anxiety

Update on the Detection of Frailty in Older Adults