NCT07744789 Knee Ligament Stiffness Across Ethnicities Before and After Osteoarthritis Treatment
| NCT ID | NCT07744789 |
| Status | Recruiting |
| Phase | — |
| Sponsor | National Taiwan University Hospital |
| Condition | Knee Osteoarthritis |
| Study Type | OBSERVATIONAL |
| Enrollment | 208 participants |
| Start Date | 2023-07-26 |
| Primary Completion | 2027-07-01 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
This is an observational study. You will not receive an experimental treatment; researchers will collect data based on your existing condition or standard treatment.
This trial targets 208 participants in total. It began in 2023-07-26 with a primary completion date of 2027-07-01.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
This prospective clinical study aims to establish normative values of knee ligament stiffness across different ethnic populations using shear wave elastography (SWE) and to investigate biomechanical alterations associated with knee osteoarthritis (OA). Healthy adults and patients with symptomatic knee OA will undergo standardized SWE examinations of the anterior cruciate ligament (ACL), posterior cruciate ligament (PCL), medial collateral ligament (MCL), and lateral collateral ligament (LCL), together with clinical assessments. For patients who subsequently receive clinically indicated ultrasound-guided injection therapy, follow-up SWE and clinical evaluations will be performed to investigate changes in ligament stiffness after treatment.
Eligibility Criteria
Inclusion Criteria * Healthy volunteers: * Adults aged 20 years or older. * Able to understand the study procedures and provide written informed consent. * Able to ambulate independently without walking aids. * No pain in either knee during the previous 6 months. * Patients with symptomatic knee osteoarthritis: * Adults aged 20 years or older. * Able to understand the study procedures and provide written informed consent. * Pain in at least one knee during the previous year. * Knee pain, soreness, or stiffness documented within the previous month. * Radiographic knee osteoarthritis defined by at least one of the following: * Kellgren-Lawrence grade ≥2 on anteroposterior radiographs. * Kellgren-Lawrence grade ≥2 on skyline radiographs. * Superior or inferior patellar osteophytes or posterior tibial osteophytes on lateral radiographs. Exclusion Criteria * Healthy volunteers: * Previous knee surgery. * Rupture of any cruciate or collateral ligament. * Major knee or periarticular trauma. * Rheumatic or autoimmune disease. * Diagnosis of knee osteoarthritis within the previous 6 months. * Patients with symptomatic knee osteoarthritis: * Rheumatic or autoimmune disease. * Malignancy. * Previous major knee trauma or knee surgery. * Corticosteroid injection into the affected knee within the previous 3 months.
Contact & Investigator
Frequently Asked Questions
Who can join the NCT07744789 clinical trial?
This trial is open to participants of all sexes, aged 20 Years or older, studying Knee Osteoarthritis. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07744789 currently recruiting?
Yes, NCT07744789 is actively recruiting participants. Contact the research team at kvchang011@gmail.com for enrollment information.
Where is the NCT07744789 trial being conducted?
This trial is being conducted at Taipei, Taiwan.
Who is sponsoring the NCT07744789 clinical trial?
NCT07744789 is sponsored by National Taiwan University Hospital. The trial plans to enroll 208 participants.