← Browse by Condition
Medical Condition

knee pain chronic

Total Trials
2
Recruiting Now
2
Trial Phases
Various

Pain clinical trials span acute procedural pain, chronic musculoskeletal pain, neuropathic pain, and cancer-related pain β€” each requiring distinct trial designs and patient-reported outcome instruments. The regulatory demand for non-opioid alternatives has intensified the search for novel analgesic mechanisms, particularly ion channel targets and neurostimulation approaches.

Active trials evaluate Nav1.7/1.8 blockers, CGRP antagonists for new indications, spinal cord stimulation refinements, virtual reality-based pain management, and patient-specific ketamine infusion protocols. Pain trials increasingly use ecological momentary assessment (EMA) diary approaches over traditional recall-based pain rating scales.

Frequently Asked Questions — knee pain chronic Clinical Trials

How many clinical trials are currently recruiting for knee pain chronic?
ClinicalMetric currently tracks 2 actively recruiting clinical trials for knee pain chronic, sourced in real time from ClinicalTrials.gov. The total number of registered studies—including those not yet enrolling or in active follow-up—is 2. Trial availability changes daily as new studies open enrollment and existing ones reach capacity.
What trial phases are available for knee pain chronic?
knee pain chronic research spans multiple clinical trial phases. Phase 1 studies evaluate safety and dosing in small groups, Phase 2 studies assess preliminary efficacy in 100–300 participants, and Phase 3 trials compare the new treatment against the standard of care in 300–3,000+ patients. Phase 4 post-approval studies monitor long-term outcomes in real-world populations.
How do I find out if I qualify for a knee pain chronic clinical trial?
Eligibility criteria for knee pain chronic trials vary by study and typically specify age range, disease stage or severity, prior treatment history, and specific diagnostic or laboratory parameters. Each listing on ClinicalMetric links to the full protocol on ClinicalTrials.gov, where inclusion and exclusion criteria are documented. Contact the sponsoring site's research coordinator directly to confirm your eligibility—your treating physician or specialist can also help identify the most appropriate trial based on your medical history and current treatment status.
Top Sponsors
Dijklander Ziekenhuis 1 trial
LifeBridge Health 1 trial

Recruiting Clinical Trials

NCT06094660
Recruiting
RFA or Chemical Neurolysis of the Genicular Nerves Compared to Conservative Treatment for Knee Pain Caused by OA
Enrollment
192 pts
Location
Netherlands
Sponsor
Dijklander Ziekenhuis
View Trial →
NCT04814082
Recruiting
Prospective Functional, Gait, and Outcome Comparison Study of Medial Pivot Versus Single Radius Design for Total Knee Arthroplasty
Enrollment
100 pts
Location
United States
Sponsor
LifeBridge Health
View Trial →

Related Conditions

osteo arthritis knee (1) osteoarthritis knee (1) knee osteoarthritis (1) osteoarthritis knees both (1) osteoarthritis knee left (1) osteoarthritis knee right (1) knee disease (1) arthropathy of knee joint (1)
ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer  ·  Last Reviewed: July 2026  ·  Data Methodology