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healthy volunteers

Total Trials

29

Recruiting Now

29

Trial Phases

Phase 1, Phase 2, Phase 3, Phase 1, Phase 2

Clinical trials often recruit healthy volunteers for Phase 1 pharmacokinetic and safety studies, vaccine immunogenicity assessments, and normal physiological reference studies. These trials are essential for establishing safe dose ranges and understanding how drugs behave in the absence of disease before testing in patient populations.

Healthy volunteer studies include first-in-human drug trials, vaccine efficacy (flu, RSV, COVID-19, malaria), microbiome intervention studies, exercise physiology research, and device safety assessments. Compensation is often provided; eligibility typically requires no significant medical history and a negative drug screen.

Healthy volunteer trials require participants to be in good general health with no significant medications. Many exclude smokers, pregnant individuals, and those with recent prior trial participation.

Frequently Asked Questions — healthy volunteers Clinical Trials

How many clinical trials are currently recruiting for healthy volunteers?

ClinicalMetric currently tracks 29 actively recruiting clinical trials for healthy volunteers, sourced in real time from ClinicalTrials.gov. The total number of registered studies—including those not yet enrolling or in active follow-up—is 29. Trial availability changes daily as new studies open enrollment and existing ones reach capacity.

What trial phases are available for healthy volunteers?

healthy volunteers research spans Phase 1 (13 trials), Phase 2 (4 trials), Phase 3 (1 trial). Phase 1 studies evaluate safety and dosing in small groups, Phase 2 studies assess preliminary efficacy in 100–300 participants, and Phase 3 trials compare the new treatment against the standard of care in 300–3,000+ patients. Phase 4 post-approval studies monitor long-term outcomes in real-world populations.

How do I find out if I qualify for a healthy volunteers clinical trial?

Eligibility criteria for healthy volunteers trials vary by study and typically specify age range, disease stage or severity, prior treatment history, and specific diagnostic or laboratory parameters. Each listing on ClinicalMetric links to the full protocol on ClinicalTrials.gov, where inclusion and exclusion criteria are documented. Contact the sponsoring site's research coordinator directly to confirm your eligibility—your treating physician or specialist can also help identify the most appropriate trial based on your medical history and current treatment status.

Trial Phases

Phase 1

13

Phase 2

4

Phase 3

1

Top Sponsors

Hospices Civils de Lyon 2 trials

Hadassah Medical Organization 1 trial

Caroline Samer 1 trial

Vigonvita Life Sciences 1 trial

National Heart, Lung, and Blood Institute (NHLBI) 1 trial

Recruiting Clinical Trials

NCT07079930 Phase 1

Safety and Psychological Effects of Psilocybin and D-Serine Formulation in Healthy Volunteers

Hadassah Medical Organization

NCT07014930 Phase 1

Identification of New Tools for Predicting Natural Metabolic Performance of the Liver

NCT07240636 Phase 1

Study of Food Effects of VV119 Capsules in Chinese Healthy Volunteers

Vigonvita Life Sciences

Collection and Analysis of Blood, Bone Marrow, and Buccal Mucosa Samples From Healthy Volunteers

National Heart, Lung, and Bloo...

NCT07656454 Phase 1

A Study Understanding How Much CDR132L Enters the Bloodstream After Injection Under the Skin Compared to Injection Into a Vein in Healthy Participants

Novo Nordisk A/S

Acute Effects of High-intensity Interval Training With Mindfulness-based Recovery on Executive Function in Children

Purdue University

Effects of Museum Visits on Neurocognitive Well-being

University Hospital, Caen

NCT07853131 Phase 1

Study to Assess the Plasma Concentration of Rilzabrutinib Given as a Tablet to Adult Participants With Severe Renal Impairment Compared to Matched Participants With Normal Renal Function

NCT05587036 Phase 2, Phase 3

Effects of Rifaximin on Gut Microbiota and Emotion

Universitaire Ziekenhuizen KU ...

The Application of Wide Pulse High Frequency Neuromuscular Electrical Stimulation in Disorders Associated With Motoneuron Hyperexcitability

University of Lausanne

Assessment of the Immunomodulatory Potential of Spirulina Blue Protein Capsule on Immunomodulation in Healthy Volunteers

University of Phayao

NCT06985615 Phase 1

A Study of HDM1002 in Subjects With And Without Varying Degrees Of Hepatic Impairement

Hangzhou Zhongmei Huadong Phar...

Endurance Trial: Ketone and Carbohydrate Supplementation

University of Sao Paulo

Eco-guided Neuromodulation of the Femoral Nerve on the Performance of Amateur Athletes.

Universitat Internacional de C...

NCT07204418 Phase 1

A Study to Evaluate the Effects of CYP2D6 Phenotypes on the Pharmacokinetics of Xanomeline Following KarXT Administration in Healthy Adult Participants

Karuna Therapeutics, Inc., a B...

NCT05648214 Phase 1, Phase 2

A Trial to Learn if ALN-PNP is Safe and Well Tolerated in Healthy Adults and Adult Participants With Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)

Regeneron Pharmaceuticals

Neural Bases of Motivation

Hospices Civils de Lyon

NCT07012993 Phase 2

Ultralow Dose PET Imaging of 18F-Florbetapir, 18F-Flutemetamol

NCT07429006 Phase 1

SAD and MAD Study of AKB-9090 in Healthy Adult Participants

Akebia Therapeutics

Artificial Intelligence Delivered Cardiac Magnetic Resonance - Prospective Validation

Imperial College London

NCT04799301 Phase 1

Developing Biomarkers of Dietary Intake: Dose Dependent Measurement of Sugar Intake

National Institute of Diabetes...

Human Skin and Gut Mycobiome and Bacteriome Comprehensive Registry

University Hospitals Cleveland...

Influence of Training Session Duration on Improvements in Physiological Resilience to Exercise

Centre Hospitalier Universitai...

NCT07231679 Phase 1, Phase 2

A Study to Investigate IGT-303 in Healthy Volunteers and Participants With Chronic Kidney Disease

United States, Austr...

Ingenia Therapeutics INC

Multi-Field-Strength MRI Brain Atlas Construction in Healthy Chinese Population

Tang-Du Hospital

NCT07476586 Phase 1

A Study to Evaluate the Safety, Tolerability, Pharmacokinetics of GenSci161 in Healthy Adult Participants

Changchun GeneScience Pharmace...

The Effect of Two Different Exercise Programs in Young Sailors

Turkey (Türkiye)

Istinye University

NCT07590102 Phase 1

A Study to Investigate the Effect of the CYP3A Inducer Phenytoin and the CYP3A Inhibitor Itraconazole on the Pharmacokinetics of BGB-58067 in Healthy Participants

BeOne Medicines

A New Generation of Magnetoencephalographs for High Speed Functional Brain Imaging

Hospices Civils de Lyon

Related Conditions

heart failure (1) renal impairment (1) stress (1) fear (1) stroke (1) cramp (1) restless legs syndrome (1) immune system (1) hepatic impairment (1) athletic performance (1) exercise (1) ketosis (1)

ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer · Last Reviewed: November 2026 · Data Methodology