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healthy volunteers

Total Trials

24

Recruiting Now

24

Trial Phases

Phase 1, Phase 2, Phase 2, Phase 3

Clinical trials often recruit healthy volunteers for Phase 1 pharmacokinetic and safety studies, vaccine immunogenicity assessments, and normal physiological reference studies. These trials are essential for establishing safe dose ranges and understanding how drugs behave in the absence of disease before testing in patient populations.

Healthy volunteer studies include first-in-human drug trials, vaccine efficacy (flu, RSV, COVID-19, malaria), microbiome intervention studies, exercise physiology research, and device safety assessments. Compensation is often provided; eligibility typically requires no significant medical history and a negative drug screen.

Healthy volunteer trials require participants to be in good general health with no significant medications. Many exclude smokers, pregnant individuals, and those with recent prior trial participation.

Frequently Asked Questions — healthy volunteers Clinical Trials

How many clinical trials are currently recruiting for healthy volunteers?

ClinicalMetric currently tracks 24 actively recruiting clinical trials for healthy volunteers, sourced in real time from ClinicalTrials.gov. The total number of registered studies—including those not yet enrolling or in active follow-up—is 24. Trial availability changes daily as new studies open enrollment and existing ones reach capacity.

What trial phases are available for healthy volunteers?

healthy volunteers research spans Phase 1 (14 trials), Phase 2 (4 trials), Phase 3 (1 trial). Phase 1 studies evaluate safety and dosing in small groups, Phase 2 studies assess preliminary efficacy in 100–300 participants, and Phase 3 trials compare the new treatment against the standard of care in 300–3,000+ patients. Phase 4 post-approval studies monitor long-term outcomes in real-world populations.

How do I find out if I qualify for a healthy volunteers clinical trial?

Eligibility criteria for healthy volunteers trials vary by study and typically specify age range, disease stage or severity, prior treatment history, and specific diagnostic or laboratory parameters. Each listing on ClinicalMetric links to the full protocol on ClinicalTrials.gov, where inclusion and exclusion criteria are documented. Contact the sponsoring site's research coordinator directly to confirm your eligibility—your treating physician or specialist can also help identify the most appropriate trial based on your medical history and current treatment status.

Trial Phases

Phase 1

14

Phase 2

4

Phase 3

1

Top Sponsors

Bristol-Myers Squibb 2 trials

National Institute of Allergy and Infectious Diseases (NIAID) 1 trial

LinGang Laboratory 1 trial

Pharmbio Korea Co., Ltd. 1 trial

Takeda 1 trial

Recruiting Clinical Trials

NCT07226817 Phase 1

A Study to Assess the Relative Bioavailability of BMS-986435 and Food Effect on the BMS-986435 in Healthy Adult Participants

Bristol-Myers Squibb

Sample Collection From Healthy Volunteers for Assay Optimization

National Institute of Allergy ...

NCT07522970 Phase 1

A Phase I Clinical Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of LG-0317 in Healthy Participants

LinGang Laboratory

NCT07161180 Phase 1

Evaluation of the Pharmacokinetics of "PBK_M2301" in Healthy Adults

Pharmbio Korea Co., Ltd.

NCT07229911 Phase 1

A Study of TAK-781 in Healthy Volunteers and in Participants With Non-Cirrhotic Primary Sclerosing Cholangitis (PSC)

Cytapheresis of Volunteer Donors

National Institute on Aging (N...

NCT07260851 Phase 1

Bioequivalence Study for the Safety and the Pharmacokinetics of DWJ1622, DWC202313, and DWC202314 in Healthy Volunteers Under Fasting Conditions

Daewoong Pharmaceutical Co. LT...

NCT07248839 Phase 1

A Study to Assess the Drug Levels and Safety of BMS-986435 in Participants With Normal Hepatic Function and Participants With Different Degrees of Hepatic Impairment

Bristol-Myers Squibb

Showers and Stress

Catholic University of the Sac...

NCT06693375 Phase 2

To Evaluate Dose and Safety of NanoEcho Particle-1 Using NanoEcho Imaging Device Examinations of Rectal Lymph Nodes in Healthy Volunteers and Rectal Cancer Patients.

Xenon-129 Magnetic Resonance Imaging of Healthy Subjects: Hardware and Software Development and Reproducibility

Western University, Canada

NCT07612020 Phase 1

A Study to Assess the Absolute Bioavailability of Empasiprubart SC Administered With an Autoinjector and the Pharmacokinetic Noninferiority of Empasiprubart SC Versus Intravenous (IV) in Healthy Adult Participants

NCT05587036 Phase 2, Phase 3

Effects of Rifaximin on Gut Microbiota and Emotion

Universitaire Ziekenhuizen KU ...

NCT07342114 Phase 1

A Dose-Escalation Study of RO7875913 in Healthy Participants

Genentech, Inc.

NCT07308236 Phase 1

A Study to Determine the Metabolism and Excretion of [14C]E2086 in Healthy Male Participants

NCT04799301 Phase 1

Developing Biomarkers of Dietary Intake: Dose Dependent Measurement of Sugar Intake

National Institute of Diabetes...

Study of Emotional Regulation and Underlying Prefrontal Activity in Binge Eating Disorder

Centre Hospitalier Universitai...

NCT07527221 Phase 1

Safety and Tolerability of ZE74-0282 in Healthy Volunteers

Eilean Therapeutics AU Pty Ltd

NCT07532135 Phase 1

Safety of Mulberry Leaf Extract Capsule on Blood Glucose Control in Healthy Volunteer

Chulalongkorn University

NCT07284589 Phase 2

Ultralow Dose PET Imaging of SSTR2 Radiotracer Uptake

NCT05648214 Phase 1, Phase 2

A Trial to Learn if ALN-PNP is Safe and Well Tolerated in Healthy Adults and Adult Participants With Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)

Regeneron Pharmaceuticals

NCT07118215 Phase 1

A Study to Evaluate the Effects of KarXT on the Drug Levels of Midazolam, Fexofenadine, and Digoxin

Karuna Therapeutics, Inc., a B...

Children s Growth and Behavior Study

Eunice Kennedy Shriver Nationa...

Generalization and Specificity of Visual Learning During Sleep

Brown University

Related Conditions

primary sclerosing cholangitis (1) hepatic impairment (1) rectal cancer patients (1) stress (1) fear (1) diet therapy (1) binge eating disorder (1) emotional eating (1) non diabetic hyperglycemia (1) healthy controls (1) neuroendocrine ne tumors (1) metabolic dysfunction associated steatotic liver disease masld (1)

ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer · Last Reviewed: April 2026 · Data Methodology