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healthy volunteers

Total Trials

25

Recruiting Now

25

Trial Phases

Phase 1, EARLY_Phase 1, Phase 1, Phase 2

Clinical trials often recruit healthy volunteers for Phase 1 pharmacokinetic and safety studies, vaccine immunogenicity assessments, and normal physiological reference studies. These trials are essential for establishing safe dose ranges and understanding how drugs behave in the absence of disease before testing in patient populations.

Healthy volunteer studies include first-in-human drug trials, vaccine efficacy (flu, RSV, COVID-19, malaria), microbiome intervention studies, exercise physiology research, and device safety assessments. Compensation is often provided; eligibility typically requires no significant medical history and a negative drug screen.

Healthy volunteer trials require participants to be in good general health with no significant medications. Many exclude smokers, pregnant individuals, and those with recent prior trial participation.

Frequently Asked Questions — healthy volunteers Clinical Trials

How many clinical trials are currently recruiting for healthy volunteers?

ClinicalMetric currently tracks 25 actively recruiting clinical trials for healthy volunteers, sourced in real time from ClinicalTrials.gov. The total number of registered studies—including those not yet enrolling or in active follow-up—is 25. Trial availability changes daily as new studies open enrollment and existing ones reach capacity.

What trial phases are available for healthy volunteers?

healthy volunteers research spans Phase 1 (14 trials), Phase 2 (5 trials). Phase 1 studies evaluate safety and dosing in small groups, Phase 2 studies assess preliminary efficacy in 100–300 participants, and Phase 3 trials compare the new treatment against the standard of care in 300–3,000+ patients. Phase 4 post-approval studies monitor long-term outcomes in real-world populations.

How do I find out if I qualify for a healthy volunteers clinical trial?

Eligibility criteria for healthy volunteers trials vary by study and typically specify age range, disease stage or severity, prior treatment history, and specific diagnostic or laboratory parameters. Each listing on ClinicalMetric links to the full protocol on ClinicalTrials.gov, where inclusion and exclusion criteria are documented. Contact the sponsoring site's research coordinator directly to confirm your eligibility—your treating physician or specialist can also help identify the most appropriate trial based on your medical history and current treatment status.

Trial Phases

Phase 1

14

Phase 2

5

Top Sponsors

Hospices Civils de Lyon 2 trials

National Heart, Lung, and Blood Institute (NHLBI) 2 trials

Alnylam Pharmaceuticals 1 trial

Centre Hospitalier Universitaire de Besancon 1 trial

Changchun GeneScience Pharmaceutical Co., Ltd. 1 trial

Recruiting Clinical Trials

NCT07535606 Phase 1

A Study to Evaluate ALN-4915 in Adult Healthy Volunteers

Alnylam Pharmaceuticals

A New Generation of Magnetoencephalographs for High Speed Functional Brain Imaging

Hospices Civils de Lyon

Study of Emotional Regulation and Underlying Prefrontal Activity in Binge Eating Disorder

Centre Hospitalier Universitai...

NCT07476586 Phase 1

A Study to Evaluate the Safety, Tolerability, Pharmacokinetics of GenSci161 in Healthy Adult Participants

Changchun GeneScience Pharmace...

NCT06615986 EARLY_Phase 1

Human Milk Oligosaccharide-Based Synbiotic Supplement for Intestinal Microbiota Dysbiosis

National Heart, Lung, and Bloo...

NCT04755699 EARLY_Phase 1

Chronic Transcutaneous Stimulation to Promote Motor Function and Recovery in Individuals With Paralysis or Paresis

Northwell Health

Collection and Analysis of Blood, Bone Marrow, and Buccal Mucosa Samples From Healthy Volunteers

National Heart, Lung, and Bloo...

NCT07248839 Phase 1

A Study to Assess the Drug Levels and Safety of BMS-986435 in Participants With Normal Hepatic Function and Participants With Different Degrees of Hepatic Impairment

Bristol-Myers Squibb

NCT05648214 Phase 1, Phase 2

A Trial to Learn if ALN-PNP is Safe and Well Tolerated in Healthy Adults and Adult Participants With Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)

Regeneron Pharmaceuticals

NCT06693375 Phase 2

To Evaluate Dose and Safety of NanoEcho Particle-1 Using NanoEcho Imaging Device Examinations of Rectal Lymph Nodes in Healthy Volunteers and Rectal Cancer Patients.

Temporal Interference Methods for Non-invasive Deep Brain Stimulation, Study 1.3

Indiana University

NCT07271693 Phase 1

A Study to Determine the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of RO7806881 in Healthy Participants

Hoffmann-La Roche

Sociocultural & Biobehavioral Influences on Pain Expression and Assessment

National Center for Complement...

Preparation and Feasibility of Exams for Expected Studies

University Hospital, Grenoble

NCT07143318 Phase 1

First-in-Human Single and Multiple Dose of KLA578-1 for Injection

Hunan Kelun Pharmaceutical Co....

NCT06645691 Phase 2

Hyperpolarized MR Imaging with Carbon-13 Pyruvate in the Human Body

National Heart Centre Singapor...

NCT07570992 Phase 1

A Research Study to Evaluate the Safety of NNC1679-0001 When Given to Healthy Participants and Participants With T2DM

Novo Nordisk A/S

NCT06682975 Phase 1

A Research Study Looking at the Safety of Single and Multiple Doses of ZP9830 and How it Works in the Body of Healthy Participants

NCT06752122 Phase 1

Safety, Tolerability, and Pharmacokinetics of RCS-21 in Healthy Volunteers.

NCT07457723 Phase 2

Gut Microbiome and Metabolic Health Study

RDC Clinical Pty Ltd

A Technical Innovation of Prismatic Adaptation Test in Healthy Subject, in Favour of Autonomy and Independence in Daily Life Following a Brain Injury

Hospices Civils de Lyon

NCT07014930 Phase 1

Identification of New Tools for Predicting Natural Metabolic Performance of the Liver

NCT02543983 Phase 2

Neurobiology of Suicide

National Institute of Mental H...

NCT07034183 Phase 1

A First-in-Human Study of PRD001

PRD Therapeutics, Inc.

NCT06904807 Phase 1

A Phase I Study to Evaluate LIFE-001

LifeMine Therapeutics

Related Conditions

mild concussion (1) binge eating disorder (1) emotional eating (1) spinal cord injury (1) stroke (1) paralysis (1) paresis (1) neurological injury (1) hepatic impairment (1) metabolic dysfunction associated steatotic liver disease masld (1) rectal cancer patients (1) normal physiology (1)

ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer · Last Reviewed: September 2026 · Data Methodology