NCT05908214 The Application of Wide Pulse High Frequency Neuromuscular Electrical Stimulation in Disorders Associated With Motoneuron Hyperexcitability
| NCT ID | NCT05908214 |
| Status | Recruiting |
| Phase | — |
| Sponsor | University of Lausanne |
| Condition | Stroke |
| Study Type | INTERVENTIONAL |
| Enrollment | 110 participants |
| Start Date | 2023-10-01 |
| Primary Completion | 2025-12-31 |
Trial Parameters
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Brief Summary
In the present project, the investigators aim at proposing innovative ways of investigating spinal motoneuron hyperexcitability to counteract the associated impairments by using wide pulse high frequency neuromuscular electrical stimulation (WPHF NMES) in various populations. The investigators will use WPHF NMES contractions as a model to gain insights into the mechanisms underlying muscle cramps, restless legs syndrome or stroke-induced spasticity as there is evidence that they share common underlying mechanisms. The investigators will then use WPHF NMES as a training modality to improve plantar flexor neuromuscular function in stroke patients by taking advantage of their motoneuronal hyperexcitability.
Eligibility Criteria
STROKE PATIENTS: * Diagnosis of first-ever stroke (ischemic or hemorrhagic) with unilateral motor deficits from at least 6 months. Stroke will have to be confirmed from medical records and/or radiological imaging (CT scan or MRI) * Inadequate ankle control during gait defined as ankle dorsiflexion less than 5° during stance phase and 0° during swing phase; 0° = ankle neutral position) * Passive range of motion of ankle dorsiflexion at least to neutral position * Ability to walk at least 10 m with or without assistive devices * Spasticity at the triceps surae (either soleus and/or gastrocnemii) considered as a Modified Ashworth Sore ≥1 * Being available for the study period and willing to participate * No contraindication to neuromuscular electrical stimulation Contraindications for stroke patients: * Surface sensory loss of affected lower leg (defined as incapacity to feel the 60-g touch using the Semmes-Weinstein monofilament test) * Patients unable to understand indications or to pro
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