Medical Condition

depressive disorder major

Total Trials

11

Recruiting Now

11

Trial Phases

Phase 1, Phase 2, Phase 3

ClinicalMetric tracks all active clinical trials for depressive disorder major sourced from ClinicalTrials.gov. Research in this area spans early-phase safety investigations through large Phase 3 confirmatory trials, conducted by NIH-funded academic centers, independent investigators, and pharmaceutical sponsors worldwide. Each listing is updated daily as new studies open enrollment and existing ones reach capacity or complete follow-up.

Trial listings include the NCT identifier, current recruitment status, phase classification, primary and secondary endpoints, estimated enrollment size, participating countries, and direct links to the full protocol on ClinicalTrials.gov. Eligibility criteria — including age range, disease stage, and prior treatment requirements — are documented for every study to help patients and clinicians assess suitability before contacting a trial site.

Frequently Asked Questions — depressive disorder major Clinical Trials

How many clinical trials are currently recruiting for depressive disorder major?

ClinicalMetric currently tracks 11 actively recruiting clinical trials for depressive disorder major, sourced in real time from ClinicalTrials.gov. The total number of registered studies—including those not yet enrolling or in active follow-up—is 11. Trial availability changes daily as new studies open enrollment and existing ones reach capacity.

What trial phases are available for depressive disorder major?

depressive disorder major research spans Phase 1 (2 trials), Phase 2 (2 trials), Phase 3 (1 trial), Phase 4 (1 trial). Phase 1 studies evaluate safety and dosing in small groups, Phase 2 studies assess preliminary efficacy in 100–300 participants, and Phase 3 trials compare the new treatment against the standard of care in 300–3,000+ patients. Phase 4 post-approval studies monitor long-term outcomes in real-world populations.

How do I find out if I qualify for a depressive disorder major clinical trial?

Eligibility criteria for depressive disorder major trials vary by study and typically specify age range, disease stage or severity, prior treatment history, and specific diagnostic or laboratory parameters. Each listing on ClinicalMetric links to the full protocol on ClinicalTrials.gov, where inclusion and exclusion criteria are documented. Contact the sponsoring site's research coordinator directly to confirm your eligibility—your treating physician or specialist can also help identify the most appropriate trial based on your medical history and current treatment status.

Trial Phases

Phase 1

Phase 2

Phase 3

Phase 4

Top Sponsors

VA Office of Research and Development 2 trials

Washington University School of Medicine 1 trial

University of California, San Francisco 1 trial

Massachusetts General Hospital 1 trial

Mclean Hospital 1 trial

Recruiting Clinical Trials

NCT02994433 Phase 1

Recruiting

NMDA Receptor Antagonist Nitrous Oxide Targets Affective Brain Circuits

Washington University School o...

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NCT04581902

Recruiting

Biomarkers of Depression and Treatment Response

University of California, San ...

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NCT06136546 Phase 2

Recruiting

Cognitive Dysfunction and Inflammation in Depression: Experimental Inhibition Via Infliximab

Massachusetts General Hospital

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NCT05553353

Recruiting

Dosing rTMS for Depression Post-SCI

VA Office of Research and Deve...

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NCT05232032 Phase 2

Recruiting

Pharmaco-Neuroimaging Studies of Approach/Avoidance Behaviors and Post-Mortem Studies: Pharmacological Manipulation

Alpha-Amino-3-Hydroxy-5-Methyl-4- Isoxazole Propionic Acid Receptor Components of the Anti-Depressant Ketamine Response

Roflumilast as an Adjunct to Antidepressants in Major Depressive Disorder Patients

Acceptability and Feasibility of Work-Oriented Social-Cognitive Skills Training for Veterans With Serious Mental Illness

VA Office of Research and Deve...

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NCT05988333

Recruiting

Psychoeducational Intervention for Families With a Member Affected by Major Depression

University of Campania Luigi V...

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NCT05630469

Recruiting

Prediction of Antidepressant Effects of Electroconvulsive Therapy

Medical University of Vienna

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NCT04057378 Phase 4

Recruiting

Optimal Electrical Stimulus During Electroconvulsive Therapy

Related Conditions

depressive disorder treatment resistant (1) inflammation (1) spinal cord injuries (1) depression (1) anxiety disorder (1) post traumatic stress disorder (1) schizophrenia (1) bipolar disorder (1) stress disorder post traumatic (1) depression bipolar (1)

ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer · Last Reviewed: September 2026 · Data Methodology