| NCT ID | NCT07317310 |
| Status | Recruiting |
| Phase | — |
| Sponsor | National Taiwan University Hospital |
| Condition | Knee Osteoarthristis |
| Study Type | INTERVENTIONAL |
| Enrollment | 312 participants |
| Start Date | 2026-08-01 |
| Primary Completion | 2029-12-31 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 312 participants in total. It began in 2026-08-01 with a primary completion date of 2029-12-31.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
This study recruits patients with coexisting obesity and knee osteoarthritis (KOA) to implement the NTU-JO Smart Program, an innovative intervention integrating AI-assisted community-based exercise with continuous glucose monitoring (CGM). The primary objective is to investigate whether this intervention can improve glycemic control in this comorbid population. Other outcome measures include the risk of total knee arthroplasty (TKA), body weight changes, pain intensity scores, bone mineral density (BMD), cognitive function, as well as the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and Patient-Reported Outcomes Measurement Information System (PROMIS) scores, which reflect the patients' overall functional status. The project also sought to explore the long-term association of the NTU-JO Smart Program with the development of type 2 diabetes (T2D) and major renal events, thereby facilitating patient-centered early treatment.
Eligibility Criteria
Inclusion Criteria: * Age: 18 to 75 years. * Obesity status: body mass index (BMI) ≥ 27 kg/m², consistent with the obesity definition defined by the Health Promotion Administration, Ministry of Health and Welfare, Taiwan. * Diagnosis of KOA in at least one knee according to the American College of Rheumatology (ACR) criteria, with a Kellgren-Lawrence (KL) grade of 1, 2, or 3. * Symptomatic disease: defined as a WOMAC pain subscale score (range 0-20) greater than 4 at screening. * Sedentary lifestyle: defined as less than 30 minutes of physical activity per week for the past 6 months. * Informed consent: willing and able to provide written informed consent and comply with all longitudinal study procedures. * Comorbid status: participants may be included regardless of a baseline diagnosis of T2D or CKD. Stratified randomization and subgroup analyses will be conducted based on these baseline conditions. Exclusion Criteria: * KL grade 4 KOA in either knee. * Diagnosis of inflammatory arthritis, such as rheumatoid arthritis or psoriatic arthritis. * Knee arthroscopy within the past 3 months or previous surgical history of TKA. * Recent receipt of intra-articular injections (e.g., corticosteroids, hyaluronic acid) within the past 3 months. * Documented history of osteoporotic fracture in hospital or cloud-based medical records. * Type 1 diabetes. * Presence of conditions precluding safe participation in an exercise program, such as unstable cardiovascular disease or severe neurological disorders. * Participation in another interventional clinical trial within the past 3 months. * Engagement in dietary regimens likely to cause significant weight change (e.g., intermittent fasting, such as the 16:8 time-restricted eating) within 1 month prior to trial initiation. * Use of any FDA-approved weight-loss medications (e.g., semaglutide, tirzepatide) within 3 months prior to trial initiation. * History of any form of surgical treatment for weight loss. * Current use of lithium or antipsychotics at a dose equivalent to olanzapine \>20 mg/day. * Pregnant or breastfeeding women, or women of childbearing potential without adequate contraception. * Current malignancy (within the validity period of a catastrophic illness certificate), or any other clinical condition deemed unsuitable for participation by the investigator (investigator discretion). * Inability to use smart devices or telecommunication tools due to severe visual/hearing impairment or lack of internet access.
Contact & Investigator
Chien-Hsieh Chiang, MD, MPH, PhD
STUDY CHAIR
National Taiwan University Hospital & College of Medicine
Frequently Asked Questions
Who can join the NCT07317310 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, up to 75 Years, studying Knee Osteoarthristis. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07317310 currently recruiting?
Yes, NCT07317310 is actively recruiting participants. Contact the research team at jiansie@gmail.com for enrollment information.
Where is the NCT07317310 trial being conducted?
This trial is being conducted at Taipei, Taiwan, Yunlin, Taiwan.
Who is sponsoring the NCT07317310 clinical trial?
NCT07317310 is sponsored by National Taiwan University Hospital. The principal investigator is Chien-Hsieh Chiang, MD, MPH, PhD at National Taiwan University Hospital & College of Medicine. The trial plans to enroll 312 participants.