NCT07319546 Accelerated Rehabilitation in Individuals After Total Knee Arthroplasty
| NCT ID | NCT07319546 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Mahidol University |
| Condition | Knee Osteoarthristis |
| Study Type | INTERVENTIONAL |
| Enrollment | 32 participants |
| Start Date | 2025-12-01 |
| Primary Completion | 2026-12-30 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 32 participants in total. It began in 2025-12-01 with a primary completion date of 2026-12-30.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
The primary aim of this double-blind randomized controlled trial is to evaluate the effectiveness of an accelerated rehabilitation protocol on knee joint function and quality of life in individuals undergoing TKA compared to conventional rehabilitation in Dali, Yunan, China. The study will include patients aged 50-80 years who are scheduled for primary unilateral TKA. Participants will be randomly assigned to either an accelerated rehabilitation group or conventional rehabilitation group. The primary outcomes will include knee joint function, assessed using the KOOS and quality of life measures using the SF-36 surveys. The study will follow participants for 6 months post-surgery to assess longer-term outcomes. This study will not include individuals undergoing revision TKA or those with severe comorbid conditions. The results will provide critical insights into the role of accelerated rehabilitation in improving post-operative recovery, functional outcomes, and overall quality of life for TKA patients.
Eligibility Criteria
Inclusion Criteria: * Patients diagnosed with end-stage knee OA necessitating primary unilateral TKA. Exclusion Criteria: * History of joint infections, cancer, or inflammatory arthritis. * End-stage OA from rheumatoid or septic arthritis. * Individuals with neurological disorders such as Alzheimer's disease, - Parkinson's disease, stroke. * Individuals who are unable to follow a structured rehabilitation protocol. * Previous history of knee surgeries (other than arthroscopy). * Severe comorbidities that would hinder participation (e.g., advanced cardiovascular diseases). * Individuals who have severe osteoporosis.
Contact & Investigator
Komsak Sinsurin, Ph.D., DPT
STUDY CHAIR
Mahidol University
Frequently Asked Questions
Who can join the NCT07319546 clinical trial?
This trial is open to participants of all sexes, aged 50 Years or older, up to 80 Years, studying Knee Osteoarthristis. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07319546 currently recruiting?
Yes, NCT07319546 is actively recruiting participants. Contact the research team at liying.yan@student.mahidol.ac.th for enrollment information.
Where is the NCT07319546 trial being conducted?
This trial is being conducted at Dali, China.
Who is sponsoring the NCT07319546 clinical trial?
NCT07319546 is sponsored by Mahidol University. The principal investigator is Komsak Sinsurin, Ph.D., DPT at Mahidol University. The trial plans to enroll 32 participants.