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Medical Condition
chronic kidney disease
Total Trials
18
Recruiting Now
18
Trial Phases
Phase 4, Phase 1, Phase 3
Chronic kidney disease (CKD) and end-stage renal disease trials have been revitalized by SGLT2 inhibitors, which reduce CKD progression in both diabetic and non-diabetic patients through hemodynamic and anti-inflammatory mechanisms beyond glucose lowering. Targeting residual risk after SGLT2 and RAAS inhibition is the current frontier, with mineralocorticoid receptor antagonists (finerenone) already approved.
Active trials evaluate sparsentan (dual endothelin-angiotensin antagonist) in IgAN, iptacopan for complement-mediated nephropathy, bardoxolone for Alport syndrome, and dicarba-based gene therapy for FSGS. Urine biomarkers (UACR, NGAL) and eGFR slope are standard endpoints, with surrogate-to-hard endpoint validation ongoing.
Frequently Asked Questions — chronic kidney disease Clinical Trials
How many clinical trials are currently recruiting for chronic kidney disease?
ClinicalMetric currently tracks 18 actively recruiting clinical trials for chronic kidney disease, sourced in real time from ClinicalTrials.gov. The total number of registered studies—including those not yet enrolling or in active follow-up—is 18. Trial availability changes daily as new studies open enrollment and existing ones reach capacity.
What trial phases are available for chronic kidney disease?
chronic kidney disease research spans Phase 1 (1 trial), Phase 3 (1 trial), Phase 4 (1 trial). Phase 1 studies evaluate safety and dosing in small groups, Phase 2 studies assess preliminary efficacy in 100–300 participants, and Phase 3 trials compare the new treatment against the standard of care in 300–3,000+ patients. Phase 4 post-approval studies monitor long-term outcomes in real-world populations.
How do I find out if I qualify for a chronic kidney disease clinical trial?
Eligibility criteria for chronic kidney disease trials vary by study and typically specify age range, disease stage or severity, prior treatment history, and specific diagnostic or laboratory parameters. Each listing on ClinicalMetric links to the full protocol on ClinicalTrials.gov, where inclusion and exclusion criteria are documented. Contact the sponsoring site's research coordinator directly to confirm your eligibility—your treating physician or specialist can also help identify the most appropriate trial based on your medical history and current treatment status.
Trial Phases
Phase 1 1
Phase 3 1
Phase 4 1
Top Sponsors
2 trials
1 trial
1 trial
1 trial
1 trial
Recruiting Clinical Trials
NCT05981183
Recruiting
Transcutaneous Auricular Vagus Nerve Stimulation Device in CKD Population
Enrollment
20 pts
Location
United States
Sponsor
NYU Langone Health
NCT05090865
Recruiting
Dietary Potassium Liberalization in Pre-Dialysis Patients
Enrollment
30 pts
Location
Canada
Sponsor
University of Manitoba
NCT07169422
Recruiting
Improving Kidney Care in Type 2 Diabetes: A Study of Pharmacist Prescribing Versus Usual Care
Enrollment
120 pts
Location
Canada
Sponsor
Nova Scotia Health Authority
NCT02808572
Recruiting
New Biomarkers of Bone Mineral Metabolism as Cardiovascular Risk Factors in Chronic Kidney Disease Patients
Enrollment
250 pts
Location
France
Sponsor
University Hospital, Montpelli...
NCT07222683
Recruiting
The Impact of Renal Transplant on Coronary Microvascular Function Among Patients With Advanced Chronic Kidney Disease
Enrollment
80 pts
Location
United States
Sponsor
Brigham and Women's Hospital
NCT07394959
Recruiting
Hydration Guided by Remote Dielectric Sensing (ReDS) System for Preventing Acute Kidney Injury in Elderly Patients With Renal Insufficiency for Coronary Angiography and Intervention
Enrollment
320 pts
Location
China
Sponsor
Chinese PLA General Hospital
NCT06311240
Recruiting
Chronic Pain in Patients in Hemodialysis
Enrollment
40 pts
Location
Spain
Sponsor
Cardenal Herrera University
NCT07450820
Recruiting
OPTIMISE-CKD Study_Dapagliflozin Effectiveness in CKD
Enrollment
14,308 pts
Location
Spain
Sponsor
AstraZeneca
NCT03569735
Recruiting
Nanshan Elderly Cohort Study
Enrollment
20,000 pts
Location
China
Sponsor
Sun Yat-sen University
NCT07187713 Phase 4
Recruiting
ACE Reno, Pico Cell Matrix and Its Effect on eGFR in Chronic Kidney Diseases
Enrollment
300 pts
Location
Egypt
Sponsor
Ace Cells Lab Limited
NCT07361146
Recruiting
A Comparative Study of Intradialytic vs. Pre-Dialysis Physical Therapy Interventions in Individuals Undergoing Hemodialysis: A Randomized Controlled Trial
Enrollment
72 pts
Location
Kuwait
Sponsor
Mohammad Arian
NCT07561957
Recruiting
A Smart Phone Application to Improve Adoption of the 2024 Kidney Disease Improving Global Outcomes (KDIGO) Chronic Kidney Disease (CKD) Guidelines
Enrollment
80 pts
Location
Ireland
Sponsor
St. James's Hospital, Ireland
NCT06278207
Recruiting
An Observational Study Called FINEROD to Learn More About the Use of the Treatment Finerenone Including How Safe it is and How Well it Works Under Real-world Conditions
Enrollment
50,000 pts
Location
United States, Germa...
Sponsor
Bayer
NCT02813642
Recruiting
Evaluation of Cardiovascular Risk Factors in Incident Dialysis Patients
Enrollment
400 pts
Location
France
Sponsor
University Hospital, Montpelli...
NCT07572890 Phase 1
Recruiting
Adia Med of Winter Park LLC Chronic Kidney Disease Research Study
Enrollment
100 pts
Location
United States
Sponsor
Adia Med of Winter Park LLC
NCT00381121
Recruiting
University of Michigan "Nephrology Research BioBank"
Enrollment
420 pts
Location
United States
Sponsor
University of Michigan
NCT06329622 Phase 3
Recruiting
Effect of Ketosteril on Sarcopenia in Patients With Chronic Kidney Disease
Enrollment
58 pts
Location
China
Sponsor
Huashan Hospital
NCT07153939
Recruiting
Pivotal Study of the Velocity™ pAVF System
Enrollment
126 pts
Location
United States
Sponsor
Venova Medical
ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer · Last Reviewed: April 2026 · Data Methodology