The Effects of Exercise on Gut Bacteria, Mood and Cognition in Depression
Trial Parameters
Eligibility Fast-Check
Enter your details for a quick preliminary check. This does not replace medical advice.
Brief Summary
This study aims to investigate the effects of a 12-week aerobic (cardio) exercise intervention in people with Major Depressive Disorder. Measurements taken before, during, and following the 12-week intervention will include assessments of cognition, cardiorespiratory fitness, stress, mood and emotion, and gut bacteria.
Eligibility Criteria
Inclusion Criteria: * Be able to give written informed consent. * Be between 18 and 59 years of age. * Be in generally good health as determined by the investigator (excluding Major Depressive Disorder diagnosis). * Community dwelling with a current diagnosis of Major Depressive Disorder, and current depression episode/symptoms as determined via Beck's depression inventory-II (score 13-31). Exclusion Criteria: * Change of pharmacological therapy less than 2 weeks prior to beginning of study (including beginning pharmacological treatment). * Have a significant acute or chronic coexisting illness \[cardiovascular, gastrointestinal (GI) \[including functional GI disorders, inflammatory bowel disease, coeliac disease\], immunological, psychiatric \[to include formal/clinical diagnosis or as determined via participant self-report i.e., bipolar spectrum disorder, schizophrenia, or psychosis, but not anxiety disorder\], neurodevelopmental or neurodegenerative disorders, metabolic disorders \[