NCT05638464 Multisite Transcranial Direct Current Stimulation to Promote Hand Function Recovery After Stroke
| NCT ID | NCT05638464 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Chinese University of Hong Kong |
| Condition | Stroke |
| Study Type | INTERVENTIONAL |
| Enrollment | 50 participants |
| Start Date | 2021-08-13 |
| Primary Completion | 2024-12 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 50 participants in total. It began in 2021-08-13 with a primary completion date of 2024-12.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
A novel multisite high definition tDCS (HD-tDCS) in healthy people showed that such network-targeted stimulation could enhance motor excitability beyond traditional stimulation which targeting only one region. It showed that the excitability following multisite HD-tDCS was more than double the increase following conventional tDCS. To consider the various lesion site of different stroke survivors. The electrode placements based on personalized lesion profiles and anatomical features can be determined using finite element modeling, with lesion profiles generated from fMRI and advanced algorithms calculating the current density to maximize the modulation effect. Combining motor network interaction and the new multisite electrode montage may further provide a potential to facilitate stroke recovery.
Eligibility Criteria
Inclusion Criteria: * first-ever stroke, the duration after stroke exceeds 12 months; * mild to moderate upper extremity motor function deficit, determined by the Fugl-meyer assessment of upper extremity (FMAUE) scores between 15 and 53; * detectable voluntary muscle sEMG signal from flexor digitorum (FD) and extensor digitorum (ED); * scored below 3 in the Modified Ashworh Score (MAS) of FD and ED; * sufficient cognitive function to follow the assessment and training instructions, determined by Mini Mental State Examination score of more than 21. Exclusion Criteria: * history of epilepsy, or any other contradictions of brain stimulation; * severe joint contracture of elbow or shoulder, or pain induced by any other neurological, neuromuscular, and orthopedic diseases.
Contact & Investigator
Raymond Kai-yu Tong, PhD
PRINCIPAL INVESTIGATOR
Department of Biomedical Engineering, CUHK
Frequently Asked Questions
Who can join the NCT05638464 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, studying Stroke. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT05638464 currently recruiting?
Yes, NCT05638464 is actively recruiting participants. Contact the research team at kytong@cuhk.edu.hk for enrollment information.
Where is the NCT05638464 trial being conducted?
This trial is being conducted at Hong Kong, Hong Kong.
Who is sponsoring the NCT05638464 clinical trial?
NCT05638464 is sponsored by Chinese University of Hong Kong. The principal investigator is Raymond Kai-yu Tong, PhD at Department of Biomedical Engineering, CUHK. The trial plans to enroll 50 participants.
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