| NCT ID | NCT07602595 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Children's Hospital Medical Center, Cincinnati |
| Condition | Juvenile Idiopathic Arthritis (JIA) |
| Study Type | OBSERVATIONAL |
| Enrollment | 600 participants |
| Start Date | 2026-08 |
| Primary Completion | 2029-08 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
This is an observational study. You will not receive an experimental treatment; researchers will collect data based on your existing condition or standard treatment.
This trial targets 600 participants in total. It began in 2026-08 with a primary completion date of 2029-08.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
The purpose of the study is to discover at least two distinct Musculoskeletal pain subtypes. These types are caused by different brain-and-immune system signals that affect how the body feels pain, and they are also shaped by a person's biology, psychology, and social environment. Aim 1. We want to sort adolescents and young adults with long lasting muscle and bone pain into two different groups. To do this, we will look at participants' childhood medical histories, past treatments, when their pain started, the sex they were assigned at birth, what their pain feels like now, tests of how their body senses pain, and immune system markers found in their blood. We think we will find at least two different types of chronic pain groups, plus one group of patients who had a higher risk for pain (because of a rheumatic disease or past surgery) but never developed long term pain. Aim 2. We want to find out if certain patterns of inflammation in the body change how nerve cells react to pain. Aim 3: We want to understand how different biological, psychological, and social factors are connected to the chronic pain groups we identified. We think we will find certain mental, behavioral, and social risks-as well as protective factors-that help explain why some people develop long-lasting pain and others do not. We expect these factors to play different roles in each pain group, including the group that does not develop chronic pain.
Eligibility Criteria
Inclusion Criteria: * Diagnosis of rheumatic/autoimmune disease/pain condition or surgery prior to age 18; Current age 14 to 26 years; Participant (and parent/legal guardian of participants \< 18 yo) can read and write in English; At least 1 year from diagnosis of pain or rheumatic disease; For individuals with MSK surgical history, at least 1 year after initial surgical intervention; For individuals with rheumatic disease, their disease must be considered inactive Exclusion Criteria: * They have active disease, or Other major medical comorbidities have developed after surgery following MSK surgical intervention.
Contact & Investigator
Frequently Asked Questions
Who can join the NCT07602595 clinical trial?
This trial is open to participants of all sexes, aged 14 Years or older, up to 26 Years, studying Juvenile Idiopathic Arthritis (JIA). Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07602595 currently recruiting?
Yes, NCT07602595 is actively recruiting participants. Contact the research team at bridgestudy@cchmc.org for enrollment information.
Where is the NCT07602595 trial being conducted?
This trial is being conducted at Cincinnati, United States.
Who is sponsoring the NCT07602595 clinical trial?
NCT07602595 is sponsored by Children's Hospital Medical Center, Cincinnati. The trial plans to enroll 600 participants.