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Recruiting NCT02820233
Studies of Neuregulin/ERBB Signaling in Human Heart
Trial Parameters
Condition Heart Disease
Sponsor Douglas B. Sawyer
Study Type OBSERVATIONAL
Phase N/A
Enrollment 80
Sex ALL
Min Age 18 Years
Max Age N/A
Start Date 2015-06
Completion 2028-09
All Conditions
Brief Summary
This study examines the role of the epidermal growth factor (EGF) receptor family and the EGF family of ligands in the regulation of non-myocytes isolated from the human heart.
Eligibility Criteria
Inclusion Criteria: * Clinical diagnosis of severe coronary artery disease scheduled to undergo coronary artery bypass surgery. Exclusion Criteria: * less than 18 years of age * unwilling or unable to provide informed consent * known active myocarditis * hypertrophic cardiomyopathy * constrictive pericarditis or other significant pericardial disease * severe pulmonary hypertension * significant renal impairment (Cr \> 2.5 mg/dL) * severe ventricular arrhythmias * pregnancy