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Recruiting EARLY_Phase 1 NCT05219799
Sex Disparities in Hypoxic Vasodilation and Impact of Obesity
Trial Parameters
Condition Obesity
Sponsor University of Missouri-Columbia
Study Type INTERVENTIONAL
Phase EARLY_Phase 1
Enrollment 72
Sex ALL
Min Age 18 Years
Max Age 45 Years
Start Date 2023-03-14
Completion 2026-06-30
All Conditions
Interventions
Propranolol HydrochlorideIsoproterenolPhentolamine Mesylate
Brief Summary
The purpose of this project is to examine key mechanisms contributing to sex-differences in hypoxic vasodilation and the impact of obesity, with particular emphasis on the sympathetic nervous system.
Eligibility Criteria
Inclusion Criteria: * BMI \>18 kg/m2 Exclusion Criteria: * Pregnancy, breastfeeding * Diagnosed sleep apnea or AHI \>10 events/hr * Current smoking/Nicotine use * Increased risk of bleeding, pro-coagulant disorders, clotting disorders, anticoagulation therapy * Nerve/neurologic disease * Cardiovascular, hepatic, renal, respiratory disease * Blood pressure ≥140/90 mmHg * Diabetes, Polycystic ovarian syndrome * Communication barriers * Prescription medications, Sensitivity to lidocaine