Evaluation of RAY1225 in Adult Participants Who Have Obesity or Are Overweight
Trial Parameters
Brief Summary
The primary objective of this study is to demonstrate that RAY1225 is superior to placebo for percent change in body weight.
Eligibility Criteria
Inclusion Criteria: 1. Age ≥ 18 years. 2. Body mass index ≥ 28 kg/m2 or ≥24kg/m² to \<28 kg/m2 with at least 1 of the following weight-related comorbidities: a) Systolic blood pressure ≥130 mmHg or diastolic blood pressure ≥85 mmHg, or the use of at least one antihypertensive medication to maintain normal blood pressure;b) Fasting triglycerides (TG) ≥1.70 mmol/L, fasting low-density lipoprotein cholesterol (LDL-C) ≥4.1 mmol/L, fasting high-density lipoprotein cholesterol (HDL-C) \<1.04 mmol/L, or the need for at least one lipid-lowering treatment to maintain normal lipid levels; c) Obstructive sleep apnea syndrome; d) Fatty liver; e) Cardiovascular disease; e) Polycystic ovary syndrome. 3. History of at least 1 self-reported unsuccessful attempt at weight loss by diet and exercise. Exclusion Criteria: 1. Obesity known to be caused by monogenic mutations, other diseases, or medications. 2. Family or personal history of medullary thyroid carcinoma (MTC) or multiple endocrine neoplasia sy