NCT05845047 Producing Increasingly Complex Themes Using Right-hemisphere Engagement (PICTURE) Implemented With Telemedicine
| NCT ID | NCT05845047 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Johns Hopkins University |
| Condition | Aphasia |
| Study Type | INTERVENTIONAL |
| Enrollment | 70 participants |
| Start Date | 2023-05-31 |
| Primary Completion | 2031-08 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 70 participants in total. It began in 2023-05-31 with a primary completion date of 2031-08.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
The investigators propose a pilot crossover trial of 2 behavioral language treatments, with randomized order of treatments and blinded assessors, to determine if a therapy designed to stimulate right hemisphere functions (Producing Increasingly Complex Themes Using Right-hemisphere Engagement Implemented with Telemedicine - PICTURE IT; described below) is more effective in improving discourse than a published computer delivered lexical treatment (shown previously to improve naming) in subacute post-stroke aphasia.
Eligibility Criteria
Inclusion Criteria: 1. Age 18 or older 2. Premorbid proficiency in English 3. Left hemisphere ischemic or hemorrhagic stroke confirmed by imaging, which occurred either 1-4 months or ≥ 6 months ago 4. Diagnosis of aphasia secondary to stroke as defined using the Western Aphasia Battery-Revised Aphasia Quotient \< 93.8. 5. Capable of giving informed consent or indicating another to provide informed consent Exclusion Criteria: 1. Prior history of neurologic disease affecting the brain (e.g., brain tumor, multiple sclerosis, traumatic brain injury) other than stroke 2. Prior history of severe psychiatric illness, developmental disorders or intellectual disability (e.g., PTSD, schizophrenia, obsessive-compulsive disorder, autism spectrum disorders) 3. Inability to follow the treatment procedure as indicated by appropriate (not necessarily accurate) engagement during 5 probes of each. 4. Uncorrected severe visual loss or hearing loss by self-report and medical records
Contact & Investigator
Argye E Hillis, MD
PRINCIPAL INVESTIGATOR
Johns Hopkins University
Frequently Asked Questions
Who can join the NCT05845047 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, up to 99 Years, studying Aphasia. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT05845047 currently recruiting?
Yes, NCT05845047 is actively recruiting participants. Contact the research team at argye@jhmi.edu for enrollment information.
Where is the NCT05845047 trial being conducted?
This trial is being conducted at Baltimore, United States.
Who is sponsoring the NCT05845047 clinical trial?
NCT05845047 is sponsored by Johns Hopkins University. The principal investigator is Argye E Hillis, MD at Johns Hopkins University. The trial plans to enroll 70 participants.