NCT05505188 Predictive and Impact of Pain After 6 Months of Radiotherapy, in Head and Neck Cancer
| NCT ID | NCT05505188 |
| Status | Recruiting |
| Phase | — |
| Sponsor | University Hospital, Caen |
| Condition | Neuropathic Pain |
| Study Type | INTERVENTIONAL |
| Enrollment | 120 participants |
| Start Date | 2023-03-13 |
| Primary Completion | 2026-03-01 |
Eligibility & Interventions
Eligibility Fast-Check
Enter your details for a quick preliminary check. This does not replace medical advice.
What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 120 participants in total. It began in 2023-03-13 with a primary completion date of 2026-03-01.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
Head and neck cancers are a source of complications and after-effects related to the disease and treatment. These cancers and their treatment alter the quality of life of patients and generate pain with physical and psychological components. Chronic pain affects 36% of patients at 6 months and 30% after this period. These pains are responsible for the consumption of level II and III analgesics in 53% of these patients. At the same time, after the end of treatment, nearly a quarter of patients continued to smoke and half still consumed alcohol at least twice a week. The hypothesis of this research is to investigate the correlation between pain and the continuation of addictions, the occurrence of depressive states, asthenia and the alteration of the patients' global quality of life. The investigators propose a two-center prospective cohort study to evaluate this hypothesis at 6 months after radiotherapy treatment. This study is planned to include 120 patients with a first head and neck cancer whit radiotherapy as part of their treatment sequence. The expected duration of inclusion is 18 months. The identification of factors affecting survival, quality of life and patient compliance is essential to determine appropriate management, particularly by creating appropriate therapeutic education programs.
Eligibility Criteria
Inclusion Criteria: * Patients with a first Head and neck cancer whose therapeutic sequence involves radiotherapy * Patient over 18 years of age * Having given written consent * patient not previously treated with radiotherapy * Life expectancy \> 3 months * World Health Organization (WHO) score \< 3 * Histologically proven Head and Neck cancer * Stable patient, with no signs of recurrence or other progressive neoplasia at the time of the examination * Patient treated with radiotherapy * Patient fluent in French Exclusion Criteria: * Non-consenting patient * History of malignancy, other than treated and cured basal cell or cervical cancer * Patient who has had a salvage surgery other than lymph node removal * Patient with evidence of recurrence or other progressive neoplasia at the time of examination * Patient who has had previous mutilating surgery (causing sequelae of swallowing and eating) * Uncontrolled infectious pathology * Patient under 18 years of age * Patient who is not fluent in French * Patient with a psychiatric pathology that could disrupt the study or prevent the interpretation of the results.
Contact & Investigator
maxime humbert, MD
PRINCIPAL INVESTIGATOR
University Hospital, Caen
Frequently Asked Questions
Who can join the NCT05505188 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, studying Neuropathic Pain. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT05505188 currently recruiting?
Yes, NCT05505188 is actively recruiting participants. Contact the research team at humbert-m@chu-caen.fr for enrollment information.
Where is the NCT05505188 trial being conducted?
This trial is being conducted at Caen, France.
Who is sponsoring the NCT05505188 clinical trial?
NCT05505188 is sponsored by University Hospital, Caen. The principal investigator is maxime humbert, MD at University Hospital, Caen. The trial plans to enroll 120 participants.