Patient-oriented Randomized Pragmatic Feasibility Trial with RTMS in Depression and Anxiety
Trial Parameters
Eligibility Fast-Check
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Brief Summary
This trial compares intermittent theta-burst stimulation (iTBS) to low frequency repetitive transcranial magnetic stimulation (LFR) in regards to depression and anxiety outcomes in 100 patients with treatment resistant depression (TRD).
Eligibility Criteria
Inclusion Criteria: 1. are outpatients; 2. are voluntary and competent to consent to treatment; 3. are ≥ 18 years; 4. have a score ≥ 26 on the IDS-30-SR; 5. have had no increase or initiation of any psychotropic medication in the 4 weeks prior to screening; 6. able to adhere to the treatment schedule; 7. pass the TMS adult safety screening (TASS) questionnaire Exclusion Criteria: 1. have active suicidal intent; 2. are pregnant; 3. have a lifetime diagnosis of schizophrenia, bipolar disorder type I, schizophreniform, schizoaffective disorder or presence of psychotic symptoms within last 3 months; 4. have a concomitant major unstable medical illness; 5. have any significant form of dementia or any history of epilepsy; 6. have any intracranial implant (e.g., aneurysm clips, shunts, stimulators, cochlear implants, or electrodes) or any other metal object within or near the head, excluding the mouth, that cannot be safely removed; 7. If participating in psychotherapy, must have been in stab