Oral Melatonin Versus Oral Pregabalin on Postoperative Pain and Anxiety Following Spine Surgery
Trial Parameters
Brief Summary
This study aims to compare the efficacy of using Melatonin versus Pregabalin on postoperative pain and anxiety after spine surgeries.
Eligibility Criteria
Inclusion Criteria: * Patients aged 21-60 years old. * Both sexes. * Patients of American Society of Anesthesiologists (ASA) physical status I \& II. * Undergoing elective spine surgery. Exclusion Criteria: * Patient refusal. * History of allergic reactions to melatonin or pregabalin. * Patients with cardiovascular disease (ischemic heart disease, Heart Failure, Arrythmia, Heart Block). * Patients with kidney disease with (plasma creatinine level \> 1.5mg/dl). * Patients with liver disease with (aspartate transaminase, alanine transaminase, and bilirubin levels more than twice the upper limit of normal). * Psychological and cognitive disorders; dementia; major depression. * Circadian rhythm disorders such as chronic fatigue syndrome and drowsiness.