Trial Parameters
Brief Summary
Acute kidney injury is a common and serious complication of sepsis and septic shock, which may be associated with a worse outcome of the patient's condition. The exact pathophysiological mechanism of septic acute kidney injury remains a challenge. One of the possible causes appears to be endothelial dysfunction and mitochondrial damage of renal tubular cells. The aim of this study is to identify specific microRNAs associated with these pathophysiological events in sepsis and septic acute kidney injury. And to establish a new potential diagnostic or therapeutic target for the prevention or treatment of septic acute kidney injury.
Eligibility Criteria
Inclusion Criteria: The study group of patients with sepsis with or without acute kidney injury * age \> 18 years * newly diagnosed sepsis or septic shock with or without acute kidney injury Healthy volunteers * no evidence of infection on clinical or laboratory examination * age \> 18 years * signed informed consent Exclusion Criteria: The study group of patients with sepsis with or without acute kidney injury * age \< 18 years * chronic kidney disease at stage 4 or 5 according to KDIGO recommendations (KDIGO) for chronic kidney disease 2024 * patients on chronic dialysis treatment, or after renal transplantation Healthy volunteers * acute or chronic infection * renal disease