NCT07440758 Low-Flow Sevoflurane and Desflurane Anesthesia in Laparoscopic Cholecystectomy
| NCT ID | NCT07440758 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Kayseri City Hospital |
| Condition | Laparoscopic Cholecystectomy |
| Study Type | INTERVENTIONAL |
| Enrollment | 70 participants |
| Start Date | 2026-03-20 |
| Primary Completion | 2026-07-01 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 70 participants in total. It began in 2026-03-20 with a primary completion date of 2026-07-01.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
Several studies have demonstrated that inhalational anesthetic agents such as desflurane and sevoflurane may cause varying degrees of postoperative sore throat, hoarseness, and cough in orotracheally intubated patients. However, data evaluating these outcomes under low-flow anesthesia conditions remain limited and insufficient. This single-center, prospective, randomized controlled study will be conducted in patients aged 18-65 years, classified as American Society of Anesthesiologists (ASA) physical status I-II, who are scheduled to undergo elective laparoscopic cholecystectomy under general anesthesia and who provide written informed consent to participate in the study. The primary objective of the study is to compare the effects of low-flow desflurane and low-flow sevoflurane anesthesia on the incidence and severity of postoperative sore throat. The secondary outcomes include the evaluation of postoperative hoarseness and cough, the incidence of postoperative nausea and vomiting (PONV), and the total consumption of inhalational anesthetic agents.
Eligibility Criteria
Inclusion Criteria: * American Society of Anesthesiologists (ASA) physical status I-II * Aged between 18 and 65 years * Patients who provide written informed consent to participate in the study Exclusion Criteria: * Patients with a recent history of upper respiratory tract infection * Patients with a recent history of sore throat * Patients with chronic cough * Patients with a history of previous neck or tracheal surgery * Patients with predictors of difficult intubation * Patients with a history of difficult intubation * Obese patients (BMI \> 35 kg/m²) * Patients with chronic respiratory diseases (asthma, COPD) * Pregnancy * Use of dexamethasone * Patients with hepatic impairment * Patients with allergy to paracetamol, tramadol, granisetron, dexamethasone, or metoclopramide * Patients with known allergy to halogenated anesthetic agents * Patients with a history of malignant hyperthermia * Patients with mental disorders or those unable to provide reliable assessment
Contact & Investigator
Şaziye Burcu Tufanoğulları Erdoğan
PRINCIPAL INVESTIGATOR
Kayseri City Hospital
Frequently Asked Questions
Who can join the NCT07440758 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, up to 65 Years, studying Laparoscopic Cholecystectomy. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07440758 currently recruiting?
Yes, NCT07440758 is actively recruiting participants. Contact the research team at smyyclk51@gmail.com for enrollment information.
Where is the NCT07440758 trial being conducted?
This trial is being conducted at Kayseri, Turkey (Türkiye).
Who is sponsoring the NCT07440758 clinical trial?
NCT07440758 is sponsored by Kayseri City Hospital. The principal investigator is Şaziye Burcu Tufanoğulları Erdoğan at Kayseri City Hospital. The trial plans to enroll 70 participants.