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RecruitingPhase 1NCT07488078

Effect of Liberal and Restrictive IV Fluids on Recovery After Gallbladder Surgery

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Trial Parameters

ConditionLaparoscopic Cholecystectomy
SponsorKing Edward Medical University
Study TypeINTERVENTIONAL
PhasePhase 1
Enrollment380
SexALL
Min Age18 Years
Max Age60 Years
Start Date2025-12-01
Completion2026-07-28
Interventions
Lactated Ringer 500mlLactated Ringer 1000ml

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Brief Summary

The goal of this clinical trial is to learn whether giving less intravenous (IV) fluid (restrictive administration) after surgery is as effective as giving more IV fluid (liberal administration) in maintaining body stability (homeostasis) among adults undergoing laparoscopic gallbladder removal (cholecystectomy). The main questions it aims to answer are: Does restrictive IV fluid administration maintain stable blood pressure, heart rate, and urine output after laparoscopic cholecystectomy? Are there any differences in postoperative recovery or complications between restrictive and liberal fluid regimens? Researchers will compare patients receiving liberal IV fluid administration with those receiving restrictive IV fluid administration to see if both methods maintain similar postoperative homeostasis and recovery outcomes. Participants will: Be adults aged 18-60 years (ASA class I-II) undergoing elective laparoscopic cholecystectomy. Be randomly assigned to one of two groups: Group A: Liberal IV fluid administration for 6 hours after surgery. Group B: Restrictive IV fluid administration for 6 hours after surgery. Have their vital signs (pulse, blood pressure, mean arterial pressure) and urine output recorded at multiple time points after surgery (immediate, 3, 6, 12, and 24 hours).

Eligibility Criteria

Inclusion Criteria: * All patients undergoing elective cholecystectomy * Age : 18-60 years * All genders * ASA class 1 and 2 Exclusion Criteria: * History of previous laparotomy * Perforated gall bladder * Duration of surgery more than 3 hours * More than 100ml intra operative blood loss

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