NCT07286916 Impact of Guided Biofilm Therapy on Epithelial and Mesenchymal Biomarkers in Periodontitis Patients
| NCT ID | NCT07286916 |
| Status | Recruiting |
| Phase | — |
| Sponsor | University of Baghdad |
| Condition | Periodontitis |
| Study Type | INTERVENTIONAL |
| Enrollment | 18 participants |
| Start Date | 2026-01-04 |
| Primary Completion | 2026-06 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 18 participants in total. It began in 2026-01-04 with a primary completion date of 2026-06.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
The goal of this clinical trial is to investigate the clinical and biochemical effects of the guided biofilm therapy protocol as an alternative to the conventional non-surgical periodontal therapy in patients with periodontitis. The main question it aims to answer is: Does the guided biofilm therapy (GBT) protocol have an impact on gingival crevicular fluid (GCF) epithelial and mesenchymal biomarkers in patients with periodontitis? All patients will be instructed to brush their teeth twice daily and will be supplied with the same type of toothpaste and toothbrush, with suitable interdental aids. All patients will be instructed to attend again after 7 days. At baseline, full-mouth periodontal charting and radiographs will be obtained and after 1-hour, GCF samples will be collected from both test and control groups. Sites allocated to control group will undergo supragingival debridement by using ultrasonic device. After one week, the control group will receive RSD using area specific (Gracey) curettes (Medesy, Italy) according to the 24-hours protocol and will receive teeth polishing by using rubber polishing cups and tooth polishing paste, while the test group will receive a full GBT protocol which includes eight steps: (1) ASSESS, (2) DISCLOSE, (3) MOTIVATE, (4) AIRFLOW, (5) PERIOFLOW, (6) PIEZON PS\*, (7) CHECK, and (8) RECALL. After finishing the treatment session, the patients will be asked to attend for follow up, clinical evaluation of PI, BOP, PPD, and CAL, and GCF samples collection after 1 month and 3 months.
Eligibility Criteria
Inclusion Criteria: 1. Adult subjects (\>18 years). 2. Subjects are not currently under active periodontal therapy or joining other trial in the last 3 months. 3. Patients must be diagnosed with generalized unstable periodontitis with bilateral, symmetrical distribution of PPD ≥ 4mm and positive BOP. \- Exclusion Criteria: 1. Patients not diagnosed with periodontitis. 2. Patients consuming antibiotics. 3. Regular users of nonsteroidal anti-inflammatory drugs (NSAIDs). 4. Patients receiving periodontal treatment 3-months prior to the study. 5. Pregnant or mothers in a breastfeeding period. 6. Third molars and teeth with furcation involvement. 7. Patients taking antioxidant supplements. 8. Patients with heavy calculus that would prevent PerioPaper strips entrance to the periodontal pocket. 9. Patient with pulmonary diseases and with a history of allergy to erythritol. 10. Patients not willing to participate. -
Contact & Investigator
Frequently Asked Questions
Who can join the NCT07286916 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, studying Periodontitis. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07286916 currently recruiting?
Yes, NCT07286916 is actively recruiting participants. Contact the research team at Ibrahim.Ata2405@codental.uobaghdad.edu.iq for enrollment information.
Where is the NCT07286916 trial being conducted?
This trial is being conducted at Baghdad, Iraq.
Who is sponsoring the NCT07286916 clinical trial?
NCT07286916 is sponsored by University of Baghdad. The trial plans to enroll 18 participants.