NCT07597213 Hyaluronic Acid as an Adjunct to Non-Surgical Periodontal Therapy in Smokers
| NCT ID | NCT07597213 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Marmara University |
| Condition | Hyaluronic Acid |
| Study Type | INTERVENTIONAL |
| Enrollment | 23 participants |
| Start Date | 2026-07-13 |
| Primary Completion | 2028-07 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 23 participants in total. It began in 2026-07-13 with a primary completion date of 2028-07.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
The goal of this clinical trial is to evaluate whether hyaluronic acid (HA) improves periodontal healing in people with periodontal disease who smoke. Moreover, the effects of HA on biomolecules and bacteria levels will be assessed during the follow up period. The main questions it will answer are: Will periodontal sites treated with HA gel after non-surgical periodontal treatment (NSPT) lead to better outcomes in clinical parameters compared to the sites treated with NSPT only in smokers? Will adjunctive use of HA gel reduce oxidative stress markers and bacteria levels during follow-up? Researchers will compare periodontal sites receiving NSPT with adjunctive HA gel application to sites receiving NSPT alone to determine whether HA provides additional clinical, biochemical and microbiological benefits. Participants will: * first receive full-mouth NSPT then, randomization will be performed in selected jaw to determine the test sites. These two interproximal test sites will additionally receive HA gel application. * attend follow-up visits at 1, 3 and 6 months for clinical periodontal measurements and to provide gingival crevicular fluid samples (GCF) and subgingival samples. The GCF samples will be evaluated for Metallothionein (MT) and 8-hydroxy-2'-deoxyguanosine (8-OHdG) levels and subgingival samples for periodontal pathogens.
Eligibility Criteria
Inclusion Criteria: 1. Individuals who sign the informed consent form 2. Participants who are systemically healthy 3. Participants who smoke (for \>5 years and ≥10 cigarettes per day) 4. Participants diagnosed with Stage III or Stage IV periodontitis 5. Participants with at least 20 natural teeth present in the mouth (excluding third molars) 6. Participants with two non-adjacent interproximal sites in each quadrant of either jaw, presenting probing depth (PD) and clinical attachment level (CAL) ≥6 mm, and with no caries, restorations, or furcation involvement Exclusion Criteria: 1. Individuals who do not sign the informed consent form 2. Individuals having any systemic disease 3. Participants who have used antibiotics within the last 3 months 4. Participants who have received any periodontal treatment within 6 months prior to the study 5. Participants who are pregnant or lactating
Contact & Investigator
Frequently Asked Questions
Who can join the NCT07597213 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, up to 65 Years, studying Hyaluronic Acid. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07597213 currently recruiting?
Yes, NCT07597213 is actively recruiting participants. Contact the research team at basakdogan@marmara.edu.tr for enrollment information.
Where is the NCT07597213 trial being conducted?
This trial is being conducted at Istanbul, Turkey (Türkiye).
Who is sponsoring the NCT07597213 clinical trial?
NCT07597213 is sponsored by Marmara University. The trial plans to enroll 23 participants.