NCT07372794 EIT-Guided Respiratory Physiotherapy for Prolonged Mechanical Ventilation (PMV)
| NCT ID | NCT07372794 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Capital Medical University |
| Condition | Prolonged Mechanical Ventilation |
| Study Type | INTERVENTIONAL |
| Enrollment | 200 participants |
| Start Date | 2026-02-16 |
| Primary Completion | 2026-12-14 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 200 participants in total. It began in 2026-02-16 with a primary completion date of 2026-12-14.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
Patients with prolonged mechanical ventilation (PMV) frequently experience impaired ventilation distribution, respiratory muscle dysfunction, secretion retention, and delayed liberation from mechanical ventilation. Electrical impedance tomography (EIT) provides real-time bedside visualization of regional ventilation and enables individualized respiratory physiotherapy strategies. This multicenter randomized controlled trial aims to evaluate whether EIT-guided respiratory physiotherapy improves ventilator-free days at day 28 compared with conventional respiratory physiotherapy in adult patients with PMV. Respiratory physiotherapy consists of airway clearance, chest physiotherapy techniques, breathing pattern optimization, and therapeutic positioning. In the EIT-guided group, real-time EIT imaging is used to individualize physiotherapy strategies based on predefined ventilation distribution indicators, while the control group receives standardized physiotherapy according to institutional protocols without EIT guidance. Secondary outcomes include successful liberation from mechanical ventilation, diaphragm ultrasound parameters, EIT-derived ventilation distribution indices (exploratory mechanistic outcomes), ICU Mobility Scale, healthcare resource utilization, and safety outcomes.
Eligibility Criteria
Inclusion Criteria: * Age ≥ 18 years. * Invasive mechanical ventilation for ≥ 21 consecutive days. * Clinically stable and eligible for respiratory physiotherapy as determined by the treating team. * Expected to remain on invasive mechanical ventilation for at least 48 hours after enrollment. * Written informed consent obtained from the patient or legally authorized representative. Exclusion Criteria: * Contraindications to electrical impedance tomography . * Hemodynamic instability requiring high-dose vasoactive support. * Severe hypoxemia refractory to optimization. * Unstable fractures or other contraindications to mobilization or positioning. * Pregnancy. * Expected death within 48 hours.
Contact & Investigator
Frequently Asked Questions
Who can join the NCT07372794 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, studying Prolonged Mechanical Ventilation. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07372794 currently recruiting?
Yes, NCT07372794 is actively recruiting participants. Contact the research team at liyi_bjkfyy@126.com for enrollment information.
Where is the NCT07372794 trial being conducted?
This trial is being conducted at Beijing, China.
Who is sponsoring the NCT07372794 clinical trial?
NCT07372794 is sponsored by Capital Medical University. The trial plans to enroll 200 participants.