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Recruiting Phase 1 NCT07025759

Effects of Peripheral Magnetic Stimulation on Cortical Excitability in Healthy Individuals

Trial Parameters

Condition Healthy Individuals
Sponsor Universidade Federal de Pernambuco
Study Type INTERVENTIONAL
Phase Phase 1
Enrollment 18
Sex ALL
Min Age 18 Years
Max Age 40 Years
Start Date 2022-10-01
Completion 2025-09
Interventions
Peripheral magnetic stimulation (90% of RMT + 1 Hz)Peripheral magnetic stimulation (90% of RMT + 10 Hz)Peripheral magnetic stimulation (90% of RMT + 25 Hz)

Brief Summary

This study investigates the immediate effects of different parameters (frequency, intensity, and pulse number) of peripheral magnetic stimulation (rPMS) on cortical excitability in healthy individuals. Using a randomized, double-blind crossover design, the research aims to identify optimal stimulation protocols for modulating neural activity. Outcomes include measurements of motor-evoked potentials (MEPs), intracortical inhibition (ICI), and facilitation (ICF). Findings may enhance non-invasive therapeutic strategies for neurological disorders.

Eligibility Criteria

Inclusion criteria: Healthy adults aged 18-40 years, both sexes, right-handed (confirmed via Edinburgh Handedness Inventory), and for females, consistent use of contraceptive medication to mitigate hormonal influences on nervous system excitability. Exclusion criteria: Pregnancy; history of seizures or epilepsy; metallic implants in the head, spine, face, or heart; diagnosed neurological or musculoskeletal conditions interfering with assessments or interventions; or use of substances altering nervous system excitability.

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