NCT07547202 Effect of Non-Surgical Periodontal Therapy on Salivary Biomarkers in Smokers and Non-Smokers With Periodontitis
| NCT ID | NCT07547202 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Al-Mustansiriyah University |
| Condition | Periodontitis |
| Study Type | INTERVENTIONAL |
| Enrollment | 44 participants |
| Start Date | 2026-01-01 |
| Primary Completion | 2026-08-01 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 44 participants in total. It began in 2026-01-01 with a primary completion date of 2026-08-01.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
This study evaluates the effect of non-surgical periodontal therapy on salivary biomarkers (Dkk-1, Sclerostin, and PLAP-1) and clinical periodontal parameters in patients with periodontitis. Periodontitis is a chronic inflammatory disease that destroys tooth-supporting tissues. Smoking is a significant risk factor that worsens periodontal destruction and reduces the effectiveness of standard therapies. * The trial is a non-randomized comparative clinical study. * It includes 44 adult patients diagnosed with Stage II and III periodontitis. * The participants are divided into two equal groups: 22 current smokers and 22 non-smokers. * Participants will undergo a baseline examination, followed by standardized non-surgical periodontal therapy consisting of scaling and root planing. * A follow-up visit will be conducted six weeks post-therapy to repeat clinical measurements and saliva collection. * The primary objective is to evaluate changes in salivary biomarker levels and clinical parameters (Plaque Index, Gingival Index, bleeding on probing, Probing Pocket Depth, Clinical Attachment Level) after treatment.
Eligibility Criteria
Inclusion Criteria: * Systemically healthy. * Diagnosed with Stage II and III periodontitis. * Presence of ≥ 20 teeth (excluding third molars). * Current smoker OR non-smoker Exclusion Criteria: * Presence of systemic diseases affecting the periodontium. * Use of medications affecting inflammation. * Received periodontal therapy in the past 6 months. * Received antibiotic therapy in the last 3 months. * Alcohol use.
Contact & Investigator
Hussein Abdul-Rassul Hatiem, B.D.S., M.Sc. Student
✉ husseinabdulrassol@uomustansiriyah.edu.iq📞 +9647703916382
Hussein Abdul-Rassul Hatiem, B.D.S., M.Sc. Student
PRINCIPAL INVESTIGATOR
College of Dentistry / Mustansiriyah University
Frequently Asked Questions
Who can join the NCT07547202 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, studying Periodontitis. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07547202 currently recruiting?
Yes, NCT07547202 is actively recruiting participants. Contact the research team at husseinabdulrassol@uomustansiriyah.edu.iq for enrollment information.
Where is the NCT07547202 trial being conducted?
This trial is being conducted at Baghdad, Iraq, Baghdad, Iraq.
Who is sponsoring the NCT07547202 clinical trial?
NCT07547202 is sponsored by Al-Mustansiriyah University. The principal investigator is Hussein Abdul-Rassul Hatiem, B.D.S., M.Sc. Student at College of Dentistry / Mustansiriyah University. The trial plans to enroll 44 participants.