NCT07599657 Surfactant Protein D Levels in GCF Before and After MINST in Periodontitis
| NCT ID | NCT07599657 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Cairo University |
| Condition | Periodontitis |
| Study Type | INTERVENTIONAL |
| Enrollment | 18 participants |
| Start Date | 2026-05-14 |
| Primary Completion | 2027-02-01 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 18 participants in total. It began in 2026-05-14 with a primary completion date of 2027-02-01.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
This study will evaluate changes in Surfactant Protein D (SP-D) levels in gingival crevicular fluid (GCF) of patients with periodontitis before and after minimally invasive non-surgical periodontal therapy (MINST). Participants diagnosed with stage II or III periodontitis will receive minimally invasive non-surgical periodontal treatment. GCF samples will be collected at baseline and 6 months after treatment, and SP-D levels will be measured using enzyme-linked immunosorbent assay (ELISA). The study will also assess clinical periodontal outcomes, including full-mouth plaque score, full-mouth bleeding score, probing pocket depth, clinical attachment level, gingival recession, and patient satisfaction. Each participant will serve as their own control by comparing baseline values with 6-month post-treatment values.
Eligibility Criteria
Inclusion Criteria: * Male and female participants aged 18 years or older. * Diagnosis of periodontitis, classified as stage II or stage III according to the 2018 classification system. * Presence of at least one tooth with probing pocket depth (PPD) of 5 mm or more, clinical attachment loss (CAL), and radiographic evidence of bone loss. * Presence of at least one intrabony defect with a radiographic intrabony component measuring 3 mm or more. Exclusion Criteria: * Current smokers or individuals with a history of smoking within the past year. * Pregnant or lactating women. * Use of systemic antibiotics or anti-inflammatory medications within the last 3 months. * Known allergy to any materials or agents used during periodontal therapy.
Contact & Investigator
Frequently Asked Questions
Who can join the NCT07599657 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, studying Periodontitis. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07599657 currently recruiting?
Yes, NCT07599657 is actively recruiting participants. Contact the research team at hossam.eldamarany@dentistry.cu.edu.eg for enrollment information.
Where is the NCT07599657 trial being conducted?
This trial is being conducted at Cairo, Egypt.
Who is sponsoring the NCT07599657 clinical trial?
NCT07599657 is sponsored by Cairo University. The trial plans to enroll 18 participants.