NCT07325604 Effect of Neuromuscular Electrical Stimulation on Unilateral Central Facial Palsy
| NCT ID | NCT07325604 |
| Status | Recruiting |
| Phase | — |
| Sponsor | University of Aarhus |
| Condition | Facial Palsy |
| Study Type | INTERVENTIONAL |
| Enrollment | 130 participants |
| Start Date | 2026-02-27 |
| Primary Completion | 2030-12-15 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 130 participants in total. It began in 2026-02-27 with a primary completion date of 2030-12-15.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
Background Central facial palsy (CFP) is a common condition in stroke, with an estimated prevalence of 45%. CFP can lead to facial asymmetry, problems with mouth closure and food processing, bite marks on the cheek, social isolation, and reduced quality of life. CFP is seen as an important area of rehabilitation, and training is therefore often carried out to reduce the consequences of CFP. In a recent systematic review conducted by the principal investigator, the results showed that very few studies have been conducted that have investigated the effect of training for CFP, and there is currently no scientific evidence to support the effect of the various training interventions. Objective To investigate the effect of Neuromuscular electrical stimulation (NMES) on facial symmetry compared to usual practice, in participants with CFP as a result of stroke. Hypothesis: Participants who receive training with NMES together with usual training for facial paralysis have greater improvement in facial symmetry than participants who only receive usual training for facial paralysis. Trial design Randomized controlled trial (RCT) with a nested pilot trial. A pilot trial/RCT will be conducted in order to power calculation in an RCT. The protocol for the pilot trial and RCT will be the same, and participants from the pilot trial and their outcome data are thus expected to be included in the RCT.
Eligibility Criteria
Inclusion Criteria: * Central facial palsy * First time stroke * \>=18 years * Able to provide written consent Exclusion Criteria: * Not able to cooperate for mimical exercises * Contraindications for NMES * Admitted for three weeks assessment stay at the hospital
Contact & Investigator
Jesper Fabricius, PhD
PRINCIPAL INVESTIGATOR
Hammel Neurorehabilitation Centre and University Research Clinic & Department of clinical medicine, Aarhus University
Frequently Asked Questions
Who can join the NCT07325604 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, studying Facial Palsy. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07325604 currently recruiting?
Yes, NCT07325604 is actively recruiting participants. Contact the research team at jesperjm@hotmail.com for enrollment information.
Where is the NCT07325604 trial being conducted?
This trial is being conducted at Hammel, Denmark.
Who is sponsoring the NCT07325604 clinical trial?
NCT07325604 is sponsored by University of Aarhus. The principal investigator is Jesper Fabricius, PhD at Hammel Neurorehabilitation Centre and University Research Clinic & Department of clinical medicine, Aarhus University. The trial plans to enroll 130 participants.
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