NCT06903936 Comparison of the Effect of Genicular Nerve Block and Physical Therapy in Patients With Knee Osteoarthritis

Eligibility & Interventions

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What to Expect as a Participant

You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.

This trial targets 66 participants in total. It began in 2025-09-01 with a primary completion date of 2026-03-01.

Brief Summary

Knee arthritis is a chronic joint disease that causes pain, disability and impaired quality of life, leading to significant social and health problems worldwide. Moreover, these public and economic impacts related to osteoarthritis of the knee are expected to increase in the future. With the global increase in the proportion of the elderly population, overall obesity rates and the associated incidence of osteoarthritis of the knee, clinicians are now focusing on new treatment strategies. The diagnosis is usually made by history, physical examination and radiography (X-ray) and there is no need for additional examination. Today, both non-surgical and surgical interventions are used in the treatment of knee arthritis. Non-surgical options include patient education, weight loss, physical therapy (PT), support or foot orthosis, oral painkillers, non-cortisol anti-inflammatory drugs, cortisols, hyaluronic acid, plasma injections rich in platelets, prolotherapy, stem cell therapy and genicular nerve blocks. The aim of the study was to compare the benefits of genicular nerve block and physical therapy in volunteers with knee pain for more than 3 months like you and to determine the most appropriate method. In this study, Genicular nerve block and Physical therapy in patients with knee arthritis; * Effects on knee pain, mobility and functional ability * It is aimed to examine the effects on equilibrium parameters. A total of 66 participants will be included in the study. Participants will be randomly assigned to three groups by envelope selection method. Your treatment method will be determined according to the treatment method in the envelope you choose.

Eligibility Criteria

INCLUSION CRITERIA * Being between forty and seventy years old * Kellgren-Lawrence grade two-thee radiological osteoarthritis * Knee pain for at least three months * Those who consented to participate in the study according to the informed consent form EXCLUSION CRITERIA * Pregnancy * Malignancy * Epilepsy * History of cardiac pacemaker * Those who have received glucocorticosteriod, hyaluronic acid, PRP, Genicular block injection in the last six months * Those who received physical therapy in the last six months * Those taking oral glucosamine in the last six months * Anticoagulant use * History of systemic inflammatory disease * History of fracture and surgery in the lower extremity * Open wounds on the knees * History of systemic infection in the patient * Inability of the patient to cooperate * History of neuromuscular disease affecting balance parameters * Patient's unwillingness to participate in the study

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