| NCT ID | NCT06384898 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Tufts Medical Center |
| Condition | Knee Osteoarthritis |
| Study Type | INTERVENTIONAL |
| Enrollment | 480 participants |
| Start Date | 2025-04-07 |
| Primary Completion | 2027-12-31 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 480 participants in total. It began in 2025-04-07 with a primary completion date of 2027-12-31.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
The goal of this pragmatic randomized trial is to evaluate the effectiveness of remote Tai Chi to treat knee pain in adults with knee osteoarthritis. The main questions the trial aims to answer are: * Compared to routine care, will patients with Knee OA receiving remote Tai Chi exhibit greater improvement in knee-related pain (WOMAC pain score, primary outcome), pain interference (PROMIS-Pain Interference, secondary outcome), and health-related quality of life at 3 months? * Does remote tai chi decreases healthcare utilization and analgesic use over the one-year study period? Researchers will compare remote Tai Chi added to routine care to routine care alone to see if remote tai chi works to treat knee osteoarthritis pain. Participants will participate in remotely delivered web-based tai chi sessions, twice a week for 12 weeks, or will continue to receive routine care. Participants will be followed for 12 months after randomization.
Eligibility Criteria
Inclusion Criteria: * Age 50 years or older * Treating clinician diagnosis of knee osteoarthritis * Have a score of 40 (visual analog version) or greater on at least 1 of the 5 questions in the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain subscale (range of 0 to 100, with higher scores indicating greater pain) at baseline. * Able to provide informed consent * If randomized to the Routine Care group, willing to abstain from Tai Chi programs until completion of the study * If randomized to the Tai Chi group, willing to comply with the Tai Chi program (twice-a-week remote sessions for 12 weeks) * Has access to a home computer or device that will allow telehealth (bidirectional audio and video) delivery of the intervention * Is an active patient at one of the 4 participating healthcare system Exclusion Criteria: * Currently practicing Tai Chi * Serious medical conditions (e.g., dementia, significant neurological deficits or neurodegenerative disorder, active cancer treatment, psychosis, sensory deficits) limiting the participant's ability to participate in the Tai Chi safely, as determined by the principal investigators * Unable to walk without a cane or other assistive device * Any previous or scheduled knee replacement * Reports severe depression defined by a Beck Depression Inventory (BDI-II) score of 29 or more. * Reports suicidal ideations defined by a score on BDI-II item of 2 or 3 ('I would like to kill myself' or 'I would kill myself if I had the chance'). * Not English speaking * Enrollment in any other clinical trial within the last 30 days
Contact & Investigator
Chenchen Wang, MD, MSc
PRINCIPAL INVESTIGATOR
Tufts Medical Center
Frequently Asked Questions
Who can join the NCT06384898 clinical trial?
This trial is open to participants of all sexes, aged 50 Years or older, up to 100 Years, studying Knee Osteoarthritis. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT06384898 currently recruiting?
Yes, NCT06384898 is actively recruiting participants. Contact the research team at Chenchen.Wang@tuftsmedicine.org for enrollment information.
Where is the NCT06384898 trial being conducted?
This trial is being conducted at Boston, United States.
Who is sponsoring the NCT06384898 clinical trial?
NCT06384898 is sponsored by Tufts Medical Center. The principal investigator is Chenchen Wang, MD, MSc at Tufts Medical Center. The trial plans to enroll 480 participants.