NCT07086989 Cardiovascular Risk in Children With Chronic Conditions Study
| NCT ID | NCT07086989 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Semmelweis University |
| Condition | Kidney Transplant |
| Study Type | OBSERVATIONAL |
| Enrollment | 300 participants |
| Start Date | 2025-04-01 |
| Primary Completion | 2029-01-31 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
This is an observational study. You will not receive an experimental treatment; researchers will collect data based on your existing condition or standard treatment.
This trial targets 300 participants in total. It began in 2025-04-01 with a primary completion date of 2029-01-31.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
Children living with chronic health conditions face a higher risk of developing cardiovascular diseases than their peers, largely due to the accelerated aging of the heart and blood vessels. Although experts recognize this elevated risk and recommend close monitoring and early intervention, the underlying mechanisms driving this phenomenon remain poorly understood. At present, no effective interventions specifically target its root causes. Recent research shows that both large blood vessels (such as the carotid artery) and small vessels (such as those in the retina) can display early signs of damage decades before clinically apparent heart or vascular disease emerges. This accelerated vascular aging can result from multiple factors - including disease-related processes such as persistent inflammation and metabolic disturbances, treatment-related effects such as chemotherapy or long-term steroid use, and lifestyle changes associated with chronic illness, such as reduced physical activity and altered eating habits. However, it is still unclear how these factors influence the development and progression of vascular changes in children as they grow. Importantly, these changes can be monitored through non-invasive methods, offering a unique opportunity to study at-risk patients many years before overt cardiovascular disease develops. Identifying these early changes may enable us to detect and track individuals at heightened risk well in advance of clinical disease. This study aims to deepen our understanding of the causes of increased cardiovascular risk in children with chronic conditions and to lay the groundwork for earlier, more targeted prevention strategies.
Eligibility Criteria
Inclusion criteria: 1. Individuals aged between 6 and 25 years; 2. Diagnosed with a chronic childhood condition/disease associated with an increased risk of early cardiovascular disease; 3. Provided informed consent (if over 18 years old) or had informed consent provided by their legal guardian (if under 18 years old) following appropriate information about the study. Chronic childhood conditions/diseases associated with increased risk of early cardiovascular disease are defined according to the 2019 American Heart Association recommendations (https://doi.org/10.1161/CIR.0000000000000618), as well as other conditions/diseases for which at least two large-scale epidemiological studies have demonstrated an increased risk of cardiovascular disease. Exclusion criteria: 1. Severe intellectual and developmental disability; 2. Decompensated heart failure; 3. Severe primary immunodeficiency; 4. Ongoing intravenous chemotherapy; 5. Infectious diseases posing a public health risk; or 6. History of regular alcohol or drug use.
Contact & Investigator
Tamas Kiss, MD, PhD
PRINCIPAL INVESTIGATOR
Semmelweis University, Pediatric Center
Frequently Asked Questions
Who can join the NCT07086989 clinical trial?
This trial is open to participants of all sexes, aged 6 Years or older, up to 25 Years, studying Kidney Transplant. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07086989 currently recruiting?
Yes, NCT07086989 is actively recruiting participants. Contact the research team at kiss.tamas1@semmelweis.hu for enrollment information.
Where is the NCT07086989 trial being conducted?
This trial is being conducted at Budapest, Hungary, Budapest, Hungary, Budapest, Hungary.
Who is sponsoring the NCT07086989 clinical trial?
NCT07086989 is sponsored by Semmelweis University. The principal investigator is Tamas Kiss, MD, PhD at Semmelweis University, Pediatric Center. The trial plans to enroll 300 participants.
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