NCT06733714 Association of Transcranial Alternating Current Stimulation with Digital Cognitive Training for Cognitive Remediation in Older Adults
| NCT ID | NCT06733714 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Universidade Federal do Rio de Janeiro |
| Condition | Cognitive Dysfunction |
| Study Type | INTERVENTIONAL |
| Enrollment | 40 participants |
| Start Date | 2024-12-02 |
| Primary Completion | 2027-03-01 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 40 participants in total. It began in 2024-12-02 with a primary completion date of 2027-03-01.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
BACKGROUND Cognitive decline in older adults, especially those who develop Mild Cognitive Impairment and Alzheimer's Disease, currently has limited options of pharmacological treatments, with modest efficacy. Digital Cognitive Training (DCT) and Transcranial Alternating Current Stimulation (tACS) are two promising tools for cognitive remediation in this population. In this exploratory study, we investigate feasibility, tolerability and preliminary effects of the association of both interventions in older adults with cognitive complaints. METHODS Older adults with cognitive complaints are being enrolled for this study, which comprises 5 daily sessions of 30 minutes of DCT using the BrainHQ platform while simultaneously receiving theta tACS (6Hz, 1.6mA) targeting the Left Dorsolateral Prefrontal Cortex.
Eligibility Criteria
Inclusion Criteria: * Healthy subjects over 50 years old, with cognitive complaints Exclusion Criteria: * Estimated Intelligence Quotient \<80 * Dependence on psychoactive substances (DSM-V) * Severe psychiatric or neurological disorders * Uncorrected visual/hearing problems * History of syncope for an unexplained reason or seizure less than a year ago * Previous stroke * Use of anticoagulants * Intracranial metallic prosthesis or cardiac pacemaker * Any contraindication to performing tACS
Contact & Investigator
Rogerio Panizzutti, Professor
PRINCIPAL INVESTIGATOR
UFRJ
Frequently Asked Questions
Who can join the NCT06733714 clinical trial?
This trial is open to participants of all sexes, aged 50 Years or older, studying Cognitive Dysfunction. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT06733714 currently recruiting?
Yes, NCT06733714 is actively recruiting participants. Contact the research team at rogerio.panizzutti@ipub.ufrj.br for enrollment information.
Where is the NCT06733714 trial being conducted?
This trial is being conducted at Rio de Janeiro, Brazil.
Who is sponsoring the NCT06733714 clinical trial?
NCT06733714 is sponsored by Universidade Federal do Rio de Janeiro. The principal investigator is Rogerio Panizzutti, Professor at UFRJ. The trial plans to enroll 40 participants.