NCT05830942 Up-2 Study: Cognitively Engaging Walking Exercise and Neuromodulation to Enhance Brain Function in Older Adults
| NCT ID | NCT05830942 |
| Status | Recruiting |
| Phase | — |
| Sponsor | University of Florida |
| Condition | Cognitive Dysfunction |
| Study Type | INTERVENTIONAL |
| Enrollment | 120 participants |
| Start Date | 2024-04-15 |
| Primary Completion | 2027-04-30 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 120 participants in total. It began in 2024-04-15 with a primary completion date of 2027-04-30.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
Declines in cognitive function and walking function are highly intertwined in older adults. A therapeutic approach that combines complex (cognitively engaging) aerobic walking exercise with non-invasive electrical brain stimulation may be effective at restoring lost function. This study tests whether electrical stimulation of prefrontal brain regions is more beneficial than sham stimulation.
Eligibility Criteria
Inclusion Criteria: * Age 65+ * Objective executive function decline, based on standardized cognitive assessments. * Subjective cognitive decline, based on the question: "During the past 12 months, have you experienced confusion or memory loss that is happening more often or getting worse?" * Ability to walking independently for 6 minutes (use of cane permitted) Exclusion Criteria: * Major cognitive disorder that interferes with independence * Percentile score less than 10th percentile on standardized cognitive assessments * Medications that are thought to influence tDCS neuroplasticity. * Contraindications to tDCS or MRI.
Contact & Investigator
David J Clark, ScD
PRINCIPAL INVESTIGATOR
University of Florida
Frequently Asked Questions
Who can join the NCT05830942 clinical trial?
This trial is open to participants of all sexes, aged 65 Years or older, studying Cognitive Dysfunction. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT05830942 currently recruiting?
Yes, NCT05830942 is actively recruiting participants. Contact the research team at davidclark@ufl.edu for enrollment information.
Where is the NCT05830942 trial being conducted?
This trial is being conducted at Gainesville, United States, Jacksonville, United States.
Who is sponsoring the NCT05830942 clinical trial?
NCT05830942 is sponsored by University of Florida. The principal investigator is David J Clark, ScD at University of Florida. The trial plans to enroll 120 participants.