A Study of Pulmonary Hypertension Peripheral Limitations
Trial Parameters
Brief Summary
The investigators are doing this research study to compare whole body aerobic training with isolated leg training (with weights) and its impact on effectiveness in symptoms and quality of life in patients with Pulmonary Arterial Hypertension (PAH).
Eligibility Criteria
Inclusion Criteria: 1. Pulmonary Arterial Hypertension (PAH) Subjects: 1. Informed consent obtained before any trial-related activities. Trial-related activities are any procedures that are carried out as part of the trial, including activities to determine suitability for the trial. 2. NYHA Class II-IV 3. LVEF ≥ 40 % within the preceding year. 4. No hospitalizations due to heart failure in the preceding 30 days. 5. No recent initiation of pulmonary vasodilator in the last 60 days 6. Pulmonary arterial hypertension by right heart catheterization (Mean PA pressure ≥ 20 mmHg with PVR\>2 Wood units) with no evidence of heart failure with preserved ejection fraction (exercise PCWP \<25 mm Hg). 7. Symptomatic PAH patients with plan to undergo exercise RHC for reassessment of exertional symptoms 2. Healthy Controls: 1. Informed consent obtained before any trial-related activities. Trial-related activities are any procedures that are carried out as part of the trial, including activities to d