Browse by Phase
Phase 3 Clinical Trials
Phase 3 trials compare a new drug or treatment against the current standard of care in a large population (300–3,000+ participants). Successful Phase 3 results are the basis for regulatory approval.
Total Trials
495
Recruiting Now
495
Top Conditions in Phase 3
Frequently Asked Questions — Phase 3 Trials
Why are Phase 3 trials the standard for drug approval?
Phase 3 trials compare a new treatment against the current standard of care in a large, randomized population of 300–3,000+ participants. This large-scale comparative evidence is what regulatory agencies—FDA, EMA—require to approve a new drug. A successful Phase 3 trial demonstrates that the new treatment is more effective, safer, or both compared to existing options in a statistically significant, reproducible way.
What is a placebo control in a Phase 3 trial?
Many Phase 3 trials use a placebo control—a group that receives an inactive substance—to isolate the true effect of the treatment. When an established standard of care exists, control-arm participants typically receive that treatment rather than a placebo, for ethical reasons. Blinded designs prevent participants and investigators from knowing who received which treatment, reducing bias in outcome assessment.
How do I find and join a Phase 3 clinical trial?
ClinicalMetric lists all Phase 3 trials registered on ClinicalTrials.gov. Each trial card shows recruitment status, enrollment target, sponsor, conditions studied, and site locations. To join a Phase 3 trial, review the eligibility criteria and contact the trial site directly—usually an academic medical center or hospital. Your physician can facilitate a referral to the appropriate study site.
Active Phase 3 Studies
NCT06819878 Phase 3
Recruiting
A Study to Assess the Efficacy and Safety of Induction and Maintenance Therapy W...
Condition
Moderately to Severely Active Crohns Disease
Enrollment
600 pts
Location
United States, Argentina, Australia
Sponsor
Hoffmann-La Roche
NCT06422143 Phase 3
Recruiting
Pembrolizumab With or Without Maintenance Sacituzumab Tirumotecan (Sac-TMT; MK-2...
Condition
Non-small Cell Lung Cancer
Enrollment
851 pts
Location
United States, Argentina, Austria
Sponsor
Merck Sharp & Dohme LLC
NCT05983250 Phase 3
Recruiting
LEVosimendan to Improve Exercise Limitation in Patients With PH-HFpEF
Condition
Pulmonary Hypertension
Enrollment
230 pts
Location
United States, Canada
Sponsor
Tenax Therapeutics, Inc.
NCT06627790 Phase 3
Recruiting
Efficacy of a Potassium Nitrate Containing Herbal Mouthwash to a Potassium Oxala...
Condition
Dentin Hypersensitivity
Enrollment
40 pts
Location
India
Sponsor
Dr. D. Y. Patil Dental College
NCT07246590 Phase 3
Recruiting
Cantharidin Application in Patients With Common Warts (Verruca Vulgaris) (COVE-2...
Condition
Common Warts
Enrollment
300 pts
Location
United States
Sponsor
Verrica Pharmaceuticals Inc.
NCT07417397 Phase 3
Recruiting
Adjuvant TACE in HCC With High-risk Recurrence Factors
Condition
Hepatocellular Carcinoma
Enrollment
442 pts
Location
China
Sponsor
Guangxi Medical University
NCT06008197 Phase 3
Recruiting
A Study to Determine the Efficacy and Safety of Finerenone on Morbidity and Mort...
Condition
Heart Failure
Enrollment
5,200 pts
Location
United States, Argentina, Australia
Sponsor
Colorado Prevention Center
NCT06188676 Phase 3
Recruiting
Multicenter Study of Safety and Efficacy Nivolumab at the Fixed Dose 40 mg (Nivo...
Condition
Primary Mediastinal Lymphoma
Enrollment
100 pts
Location
Russia
Sponsor
National Research Center for H
NCT07567040 Phase 3
Recruiting
Delaying the Onset of Nearsightedness Until Treatment (DONUT) Clinical Trial
Condition
Myopia
Enrollment
664 pts
Location
United States
Sponsor
Ohio State University
NCT06190782 Phase 3
Recruiting
Local Therapy for Oligometastatic ESCC Patients Treated With PD-1 Inhibitor
Condition
Esophageal Squamous Cell Carcinoma
Enrollment
354 pts
Location
China
Sponsor
Fudan University
NCT07390123 Phase 3
Recruiting
Phase Ⅲ Study of Efficacy and Safety of HSK39297 Tablet in Treatment of Patients...
Condition
IgA Nephropathy (IgAN)
Enrollment
370 pts
Location
China
Sponsor
Haisco Pharmaceutical Group Co
NCT07227246 Phase 3
Recruiting
Recombinant Factor VIIa (rFVIIa) for Hemorrhagic Stroke Trial - Part 2
Condition
Intracerebral Hemorrhage
Enrollment
350 pts
Location
United States, Canada, Germany
Sponsor
Joseph Broderick, MD
NCT05899010 Phase 3
Recruiting
MIcronized PROgesterone in Frozen Embryo Transfer Cycles
Condition
Infertility
Enrollment
1,020 pts
Location
Spain
Sponsor
Fundación Santiago Dexeus Font
NCT06807424 Phase 3
Recruiting
A Study to Evaluate the Efficacy and Safety of Icotrokinra (JNJ-77242113) in Bio...
Condition
Arthritis, Psoriatic
Enrollment
750 pts
Location
United States, Argentina, Australia
Sponsor
Janssen Research & Development
NCT05931263 Phase 3
Recruiting
A Randomized Clinical Trial Comparing Chi-BEAM With BEAM Regimen Combined With A...
Condition
Newly Diagnosed Peripheral T-cell Lymphoma
Enrollment
104 pts
Location
China
Sponsor
The First Affiliated Hospital
NCT05651347 Phase 3
Recruiting
Antenatal Melatonin Supplementation for Neuroprotection in Fetal Growth Restrict...
Condition
Fetal Growth Retardation
Enrollment
336 pts
Location
Australia, New Zealand
Sponsor
Monash University
NCT06399692 Phase 3
Recruiting
REvascularization CHoices Among Under-Represented Groups Evaluation: The RECHARG...
Condition
Coronary Artery Disease
Enrollment
600 pts
Location
United States
Sponsor
Weill Medical College of Corne
NCT05546099 Phase 3
Recruiting
Patient-driven Management of BP in CKD
Condition
Chronic Kidney Disease
Enrollment
160 pts
Location
United States
Sponsor
VA Office of Research and Deve
NCT05449834 Phase 3
Recruiting
Fibrinogen Early In Severe Trauma StudY II
Condition
Trauma
Enrollment
900 pts
Location
Australia, New Zealand
Sponsor
Australian and New Zealand Int
NCT06530732 Phase 3
Recruiting
Deep Cervical Lymphatlc-Venous Anastomosis Surgery for the Treatment of Alzheime...
Condition
Alzheimer's Disease
Enrollment
60 pts
Location
China
Sponsor
Zhejiang Provincial People's H
NCT05774678 Phase 3
Recruiting
Trial Of PreoperAtive Radiation (TOPAz): A Randomized Trial Comparing Hypofracti...
Condition
Breast Cancer
Enrollment
126 pts
Location
United States
Sponsor
M.D. Anderson Cancer Center
NCT06704893 Phase 3
Recruiting
Amniotic Suspension Allograft Injection for Knee Osteoarthritis
Condition
Knee
Enrollment
160 pts
Location
Taiwan
Sponsor
Chang Gung Memorial Hospital
NCT07564414 Phase 3
Recruiting
A Research Study to Look at How Two Different Doses of CagriSema and One Dose of...
Condition
Obesity
Enrollment
2,500 pts
Location
United States, Argentina, Australia
Sponsor
Novo Nordisk A/S
NCT07166406 Phase 3
Recruiting
Testing Immunotherapy With or Without Stereotactic Body Radiation Therapy in Pat...
Condition
Advanced Hepatocellular Carcinoma
Enrollment
226 pts
Location
United States, Canada
Sponsor
NRG Oncology
NCT06754085 Phase 3
Recruiting
Study of 18F-Florastamin PET/CT Imaging in Patients With Suspected Recurrence of...
Condition
Prostate Cancer
Enrollment
131 pts
Location
China
Sponsor
HTA Co., Ltd.
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ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer · Last Reviewed: April 2026 · Data Methodology