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Recruiting Phase 3 NCT04775381

Total Post-thyroidectomy Hypocalcemia After Preoperative Cholecalciferol Supplementation

Trial Parameters

Condition Hypocalcemia
Sponsor Hôpital NOVO
Study Type INTERVENTIONAL
Phase Phase 3
Enrollment 200
Sex ALL
Min Age 18 Years
Max Age N/A
Start Date 2021-06-30
Completion 2025-12
Interventions
Vitamin D

Brief Summary

This prospective study evalue the inflence of pre operative vit D3 administration on post operative hypocalcemia in patients undergoing Total thyroidectomy

Eligibility Criteria

Inclusion Criteria: * Patient ≥ 18 years old * Patient shall be operated on for a total thyroidectomy in one time for any indication * Written informed consent (IC) obtained * Patients with affiliation to the social security system Exclusion Criteria: • Medical history of : Thyroid or parathyroid surgery Hyperparathyroidism Granulomatosis flare-up * Hypocalcemia, hypercalcemia/ hypercalciuria, or symptom of Hypocalcemia, hypercalcemia/ hypercalciuria, not due to thyroid pathologies * Chronic kidney disease grade ≥4 * Severe liver failure * 25OHD supplementation within last 3 months before surgery * Malabsorption syndrome * Known hypersensitivity to vitamin D * Medical history of calcic lithiasis * Pregnant women * Vulnerable populations (guardianship or trusteeship) * Allergies to one of the components of the fruit juice

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