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opioid use disorder Clinical Trials in United States

Active clinical trials for opioid use disorder with research sites in United States. All data sourced live from ClinicalTrials.gov — updated daily.

Active Trials: 24 // Recruiting: 24 Phases: Phase 4, Phase 2 // Updated: Daily
Total Trials
24
Recruiting Now
24
Country
🇺🇸 United States

Active Trials in United States (24)

NCT05669534 Phase 4
Recruiting

Optimizing Evidence-based HIV Prevention Targeting People Who Inject Drugs on PrEP

Enrollment
256 pts
Country
🇺🇸 United States
University of Connecticut
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NCT05487911
Recruiting

Cortical rTMS as a Treatment for Depression

Enrollment
50 pts
Country
🇺🇸 United States
Baylor College of Medicine
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NCT07632053
Recruiting

Postpartum Intervention for Mothers With Opioid Use Disorders (R33)

Enrollment
80 pts
Country
🇺🇸 United States
Stony Brook University
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NCT07232641
Recruiting

Impact of Federal and State Medications for Opioid Use Disorder (MOUD) Policy Changes During the Pandemic

Enrollment
185,810 pts
Country
🇺🇸 United States
Boston University
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NCT07369089 Phase 2
Recruiting

Targeting Treatment-Resistant OUD With Ketamine-Assisted Mindfulness Oriented Recovery Enhancement

Enrollment
88 pts
Country
🇺🇸 United States
University of California, San Diego
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NCT06718491
Recruiting

Brief Digitally-Enhanced Intervention for Reducing Alcohol Use During MOUD

Enrollment
80 pts
Country
🇺🇸 United States
Ohio State University
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NCT05589181 Phase 3
Recruiting

High Dose Buprenorphine (BUP) Induction in the Emergency Department (ED)

Enrollment
140 pts
Country
🇺🇸 United States
Rutgers, The State University of Ne...
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NCT06573476
Recruiting

Addressing Racial Disparities in Opioid Overdose Using Peer Recovery Coach Training and mHealth Platform

Enrollment
180 pts
Country
🇺🇸 United States
Friends Research Institute, Inc.
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NCT06576323
Recruiting

An Intervention Mapping Approach to Closing the Gap in Maternal OUD and Infant NAS Care (SUPPORT)

Enrollment
50 pts
Country
🇺🇸 United States
University of Pennsylvania
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NCT05729932 Phase 1
Recruiting

Cannabis and Opioid Use Disorder

Enrollment
15 pts
Country
🇺🇸 United States
Shanna Babalonis, PhD
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NCT07262190
Recruiting

NavSTAR Implementation Effectiveness Trial Across a Health System

Enrollment
720 pts
Country
🇺🇸 United States
Friends Research Institute, Inc.
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NCT06136247
Recruiting

Integrating Brain, Neurocognitive, and Computational Tools in OUD

Enrollment
192 pts
Country
🇺🇸 United States
University of Pennsylvania
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NCT07810322
Recruiting

Pilot Testing of the emPath Platform to Improve Medication for Opioid Use Disorder (MOUD) Linkage and Retention Among Adults With Opioid Use Disorder in Durham, North Carolina

Enrollment
80 pts
Country
🇺🇸 United States
Duke University
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NCT03135886
Recruiting

Project I Test: Implementing HIV Testing in Opioid Treatment Programs

Enrollment
418 pts
Country
🇺🇸 United States
Columbia University
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NCT03923374
Recruiting

Opioid Use Disorder in Pregnancy in Long-Term Maternal/Infant Outcomes

Enrollment
600 pts
Country
🇺🇸 United States
Senthil Sadhasivam
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NCT04379115
Recruiting

Optimization of NIBS for Treatment of Addiction

Enrollment
126 pts
Country
🇺🇸 United States
Case Western Reserve University
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NCT06157840
Recruiting

Development of an mHealth Behavioral Sleep Medicine Intervention for Use During Medication Assisted Treatment for MOUD

Enrollment
40 pts
Country
🇺🇸 United States
Medical University of South Carolin...
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NCT04173416
Recruiting

The Youth Opioid Recovery Support (YORS) Intervention

Enrollment
150 pts
Country
🇺🇸 United States
Potomac Health Foundations
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NCT06643988
Recruiting

Autobiographical Memory in Opioid Use Disorder

Enrollment
30 pts
Country
🇺🇸 United States
University of Pennsylvania
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NCT06338280 Phase 2
Recruiting

Remotely Observed Methadone Evaluation II

Enrollment
100 pts
Country
🇺🇸 United States
Sonara Health
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NCT07044466
Recruiting

Social Functioning in Opioid Use Disorder

Enrollment
230 pts
Country
🇺🇸 United States
Medical University of South Carolin...
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NCT06453109
Recruiting

Focused Ultrasound for the Complex Patient

Enrollment
25 pts
Country
🇺🇸 United States
Washington D.C. Veterans Affairs Me...
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NCT06416020
Recruiting

Integrating MOUD in Nonmedical Community Settings (Better Together)

Enrollment
400 pts
Country
🇺🇸 United States
Howard University
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NCT05011266 Phase 2, Phase 3
Recruiting

Efficacy of Buprenorphine and XR-Naltrexone Combination for Relapse Prevention in Opioid Use Disorder

Enrollment
180 pts
Country
🇺🇸 United States
New York State Psychiatric Institut...
View Trial →

Frequently Asked Questions

How many opioid use disorder clinical trials are active in United States?
There are currently 24 active clinical trials for opioid use disorder with sites in United States, of which 24 are actively recruiting patients.
How can I join a opioid use disorder clinical trial in United States?
To join a opioid use disorder clinical trial in United States, select a recruiting trial below and check the eligibility criteria. Contact the trial's principal investigator or the listed site in United States directly. All trials listed here are sourced from ClinicalTrials.gov, the official U.S. registry of clinical studies.
What phases are opioid use disorder trials in United States?
Active opioid use disorder trials in United States span Phase 4, Phase 2, Phase 3, Phase 1, Phase 2, Phase 3. Phase I trials test safety, Phase II test efficacy, and Phase III compare against standard treatments in larger patient populations.
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All United States Trials → Global opioid use disorder Trials → All Countries → All Trials →
ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer  ·  Last Reviewed: November 2026  ·  Data Methodology