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Recruiting NCT03923374

NCT03923374 Opioid Use Disorder in Pregnancy in Long-Term Maternal/Infant Outcomes

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Clinical Trial Summary
NCT ID NCT03923374
Status Recruiting
Phase
Sponsor Senthil Sadhasivam
Condition Opioid-use Disorder
Study Type OBSERVATIONAL
Enrollment 600 participants
Start Date 2018-09-15
Primary Completion 2026-12-30

Eligibility & Interventions

Sex Female only
Min Age 18 Years
Max Age N/A
Study Type OBSERVATIONAL
Interventions
Subutex / BuprenorphineFetal & Neonatal MRIDNA/Genetic/Pharmacokenetic Blood Draws

Eligibility Fast-Check

Enter your details for a quick preliminary check. This does not replace medical advice.

What to Expect as a Participant

This is an observational study. You will not receive an experimental treatment; researchers will collect data based on your existing condition or standard treatment.

This trial targets 600 participants in total. It began in 2018-09-15 with a primary completion date of 2026-12-30.

⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.

Brief Summary

The objective of this study is to better understand the comprehensive integration of both clinical and genetic factors that will help to identify mothers who could be at an increased risk of poor response to opioid substitution and infants at risk of significant neonatal abstinence syndrome (NAS).

Eligibility Criteria

Inclusion Criteria: * Age greater 18 years * Currently taking Buprenorphine for Opioid Use Disorder and enrolled in a prenatal opioid maintenance program in the antenatal clinic at IU Health University Hospital. * Pregnant with single baby * Planned delivery at Methodist, University or Riley Hospital Exclusion Criteria: * Serious maternal medical illness as deemed by study physician or investigator. * Known or suspected major fetal/neonatal congenital abnormalities.

Contact & Investigator

Central Contact

Senthil Sadhasivam, MD, MPH

✉ sadhasivams@upmc.edu

📞 4126474484

Principal Investigator

Senthil Sadhasivam, MD, MPH

PRINCIPAL INVESTIGATOR

University of Pittsburgh, UPMC

Frequently Asked Questions

Who can join the NCT03923374 clinical trial?

This trial is open to female participants only, aged 18 Years or older, studying Opioid-use Disorder. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.

Is NCT03923374 currently recruiting?

Yes, NCT03923374 is actively recruiting participants. Contact the research team at sadhasivams@upmc.edu for enrollment information.

Where is the NCT03923374 trial being conducted?

This trial is being conducted at Pittsburgh, United States.

Who is sponsoring the NCT03923374 clinical trial?

NCT03923374 is sponsored by Senthil Sadhasivam. The principal investigator is Senthil Sadhasivam, MD, MPH at University of Pittsburgh, UPMC. The trial plans to enroll 600 participants.

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ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer  ·  Last Reviewed: April 2026  ·  Data Methodology