To join a depression clinical trial in United States, select a recruiting trial below and check the eligibility criteria. Contact the trial's principal investigator or the listed site in United States directly. All trials listed here are sourced from ClinicalTrials.gov, the official U.S. registry of clinical studies.

What phases are depression trials in United States?

Active depression trials in United States span Phase 1, Phase 2, Phase 4. Phase I trials test safety, Phase II test efficacy, and Phase III compare against standard treatments in larger patient populations.

Browse More

All United States Trials → Global depression Trials → All Countries → All Trials →

ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer · Last Reviewed: September 2026 · Data Methodology

Active Trials in United States (24)

Mechanism of Action Underlying Ketamine's Antidepressant Effects: The AMPA Throughput Theory in Patients With Treatment-Resistant Major Depression

Brain Stimulation and Decision-making

Dosing rTMS for Depression Post-SCI

The Efficacy of Psilocybin Therapy for Depression in Parkinson's Disease

Evaluation of a Keto-Like Supplement on Brain Responses to Emotional Stimuli in Depression

Mindfulness and Meditation Based Lactation Education on Maternal Breastmilk in the Neonatal ICU

Clemastine for Improving White Matter and Boosting Antidepressant Response in Late-life Depression

Self-Help Cognitive Processing Therapy (CPT)/Women Veterans Network (WoVeN) Study

Transdiagnostic Cognitive Biomarkers

SilverCloud as a School-Based Intervention for Vulnerable Youth

CBT Enhanced With Social Cognitive Training vs. CBT Only With Depressed Youth

Pharmacy-led Transitions of Care Intervention to Improve Medication Adherence

Transdiagnostic Sleep and Circadian Intervention + Bright Light in Adolescents With Elevated Depression (TranS-C+BL)

Impact of Depression on Thermoregulation

Veteran's Perceptions of Ketamine-Assisted Psychotherapy for Depression and End-of-Life

Buspirone and Melatonin for Depression Following Traumatic Brain Injury

Being Safe, Healthy, And Positively Empowered (BSHAPE) Intervention Study

Neurobiology of Suicide

Tele-PROTECT Therapy: Effectiveness, Empowerment, and Implementation

Study of the Safety, Tolerability, Electrophysiological Effects and Efficacy of DMT in Humans

Apimostinel + Automated Neurocognitive Training for Depression

Empower@Home: Hybrid Effectiveness-Implementation Randomized Controlled Trial (RCT)

Effects of Spirulina Supplementation on Mental Health in Healthy Adults

Lay-Delivered Behavioral Activation in Senior Centers

Frequently Asked Questions