🇺🇸 United States Country × Condition
depression Clinical Trials in United States
Active clinical trials for depression with research sites in United States. All data sourced live from ClinicalTrials.gov — updated daily.
Active Trials: 33 // Recruiting: 33 Phases: Phase 2, Phase 3, Phase 2 // Updated: Daily
Total Trials
33
Recruiting Now
33
Country
🇺🇸 United States
Active Trials in United States (33)
NCT05474846 Phase 2, Phase 3
Recruiting
Combination Therapy for Treatment of Sleep Disturbance in Patients With Advanced Cancer
Enrollment
188 pts
Country
🇺🇸 United States
M.D. Anderson Cancer Center
View Trial → NCT07220486
Recruiting
Behavioral Health Program for Short-Stay Nursing Facility Residents & Care Partners
Enrollment
100 pts
Country
🇺🇸 United States
Massachusetts General Hospital
View Trial → NCT05553353
Recruiting
Dosing rTMS for Depression Post-SCI
Enrollment
24 pts
Country
🇺🇸 United States
VA Office of Research and Developme...
View Trial → NCT06696001
Recruiting
Neuroscience of Psychotherapy for Depression
Enrollment
45 pts
Country
🇺🇸 United States
University of North Carolina, Chape...
View Trial → NCT06039930
Recruiting
Tele-PROTECT Therapy: Effectiveness, Empowerment, and Implementation
Enrollment
140 pts
Country
🇺🇸 United States
Weill Medical College of Cornell Un...
View Trial → NCT06326905
Recruiting
CAPABLE Transplant
Enrollment
43 pts
Country
🇺🇸 United States
Johns Hopkins University
View Trial → NCT04752618
Recruiting
Safe Mothers, Safe Children Initiative
Enrollment
160 pts
Country
🇺🇸 United States
New York University
View Trial → NCT06721559
Recruiting
Empower@Home: Community Implementation for Older Adults With Ambulatory Disabilities
Enrollment
64 pts
Country
🇺🇸 United States
University of Michigan
View Trial → NCT05763537
Recruiting
Understanding the Role of Doulas in Supporting People With PMADs
Enrollment
75 pts
Country
🇺🇸 United States
University of Montana
View Trial → NCT06725160
Recruiting
Parent Encouragement And Coaching of Happiness in Youth
Enrollment
180 pts
Country
🇺🇸 United States
University of Pittsburgh
View Trial → NCT05405803
Recruiting
To Improve Depressive Symptoms Using a Web-App
Enrollment
300 pts
Country
🇺🇸 United States
University of Texas at Austin
View Trial → NCT06262178
Recruiting
Parenting STAIR: Adapting a Trauma-Focused Parenting Intervention for Military-Connected Mothers and Their Children
Enrollment
120 pts
Country
🇺🇸 United States
New York University
View Trial → NCT02604277
Recruiting
Suicidal Behavior in Patients Diagnosed With Bipolar Disorder
Enrollment
130 pts
Country
🇺🇸 United States
Emory University
View Trial → NCT07219875 Phase 2
Recruiting
Training Reward Responsiveness Through Virtual Reality
Enrollment
80 pts
Country
🇺🇸 United States
University of California, Los Angel...
View Trial → NCT07346014
Recruiting
Sleep and Circadian Interventions for College Students at High Risk of Suicide
Enrollment
90 pts
Country
🇺🇸 United States
University of Pittsburgh
View Trial → NCT03065335 Phase 1
Recruiting
Neuropharmacologic Imaging and Biomarker Assessments of Response to Acute and Repeated-Dosed Ketamine Infusions in Major Depressive Disorder
Enrollment
150 pts
Country
🇺🇸 United States
National Institute of Mental Health...
View Trial → NCT04263285
Recruiting
Treatment of Depression Post-SCI
Enrollment
14 pts
Country
🇺🇸 United States
Medical University of South Carolin...
View Trial → NCT03388606
Recruiting
Characterization and Treatment of Adolescent Depression
Enrollment
4,100 pts
Country
🇺🇸 United States
National Institute of Mental Health...
View Trial → NCT05559749
Recruiting
Collaborative Care for Anxiety and Depression in Epilepsy
Enrollment
60 pts
Country
🇺🇸 United States
Wake Forest University Health Scien...
View Trial → NCT06261463
Recruiting
Hybrid Type 1 Randomized Pilot Trial of a Peer-led Family and Social Strengthening Group Intervention for Refugee Families
Enrollment
74 pts
Country
🇺🇸 United States
University of Illinois at Chicago
View Trial → NCT07091968
Recruiting
Feasibility of a Technology-Based Intervention for Depression Referral Uptake in Cancer Survivors
Enrollment
60 pts
Country
🇺🇸 United States
Medical University of South Carolin...
View Trial → NCT05563805
Recruiting
Exploring Virtual Reality Adventure Training Exergaming
Enrollment
40 pts
Country
🇺🇸 United States
The University of Texas at Arlingto...
View Trial → NCT06652503
Recruiting
The Student Wellness and Emotional Growth Resiliency (SWAG-R) Program
Enrollment
160 pts
Country
🇺🇸 United States
Nova Southeastern University
View Trial → NCT02543983 Phase 2
Recruiting
Neurobiology of Suicide
Enrollment
325 pts
Country
🇺🇸 United States
National Institute of Mental Health...
View Trial → NCT06073886 Phase 2
Recruiting
Personalized Brain Stimulation to Treat Chronic Concussive Symptoms
Enrollment
75 pts
Country
🇺🇸 United States
University of California, Los Angel...
View Trial → NCT06400121 Phase 2
Recruiting
Apimostinel + Automated Neurocognitive Training for Depression
Enrollment
150 pts
Country
🇺🇸 United States
Rebecca Price
View Trial → NCT05294991
Recruiting
Wellness App for Sleep Disturbance in Hematological Cancer Patients
Enrollment
276 pts
Country
🇺🇸 United States
The University of Texas Health Scie...
View Trial → NCT07224165
Recruiting
Developing a Digital Intervention for Adolescent Nonsuicidal Self-injury
Enrollment
80 pts
Country
🇺🇸 United States
Northwestern University
View Trial → NCT06263660 Phase 2
Recruiting
Evaluation of a Keto-Like Supplement on Brain Responses to Emotional Stimuli in Depression
Enrollment
75 pts
Country
🇺🇸 United States
Laureate Institute for Brain Resear...
View Trial → NCT06419439 Phase 2
Recruiting
Ketamine-assisted Integrative Treatment for Veterans With Chronic Low Back Pain and Comorbid Depression
Enrollment
44 pts
Country
🇺🇸 United States
VA Office of Research and Developme...
View Trial → NCT05543083
Recruiting
Cognitive-Behavioral Therapy and Exercise Training in Adolescents At-Risk for Type 2 Diabetes
Enrollment
300 pts
Country
🇺🇸 United States
Colorado State University
View Trial → NCT06753123
Recruiting
Be Well at Work-Plus: A Depression and Physical Activity Intervention for Hospital Service Workers (Aim 2)
Enrollment
10 pts
Country
🇺🇸 United States
San Diego State University
View Trial → NCT06597695 Phase 1, Phase 2
Recruiting
A Ketamine-assisted Group Therapy Intervention for Spanish-speaking Adults With Depression
Enrollment
10 pts
Country
🇺🇸 United States
Juliana Zambrano, MD, MPH
View Trial → Frequently Asked Questions
How many depression clinical trials are active in United States?
There are currently 33 active clinical trials for depression with sites in United States, of which 33 are actively recruiting patients.
How can I join a depression clinical trial in United States?
To join a depression clinical trial in United States, select a recruiting trial below and check the eligibility criteria. Contact the trial's principal investigator or the listed site in United States directly. All trials listed here are sourced from ClinicalTrials.gov, the official U.S. registry of clinical studies.
What phases are depression trials in United States?
Active depression trials in United States span Phase 2, Phase 3, Phase 2, Phase 1, Phase 1, Phase 2. Phase I trials test safety, Phase II test efficacy, and Phase III compare against standard treatments in larger patient populations.
ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer · Last Reviewed: July 2026 · Data Methodology