To join a depression clinical trial in United States, select a recruiting trial below and check the eligibility criteria. Contact the trial's principal investigator or the listed site in United States directly. All trials listed here are sourced from ClinicalTrials.gov, the official U.S. registry of clinical studies.

What phases are depression trials in United States?

Active depression trials in United States span Phase 1, Phase 2, EARLY_Phase 1. Phase I trials test safety, Phase II test efficacy, and Phase III compare against standard treatments in larger patient populations.

Browse More

All United States Trials → Global depression Trials → All Countries → All Trials →

ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer · Last Reviewed: November 2026 · Data Methodology

Active Trials in United States (24)

taVNS or TMS or Both for Depression

An Exploratory Study Examining Biopsychosocial Markers of Anxiety and Depression

Safe Mothers, Safe Children Initiative

Antidepressant Adherence for Depressed Adults in Primary Care

Digitally Enhanced Stepped-Care for Depression in Primary Care

Combined Neuromodulation and Cognitive Training for Post-mTBI Depression

[18F]PF-06445974 to Image PDE4B in Major Depressive Disorder Using PET

TRIPS - Treatment to Improve Depression and/or Anxiety Using Psilocybin-assisted Psychotherapy in Cancer Survivors

ACT Together: Implementing a Web-Based Program With Brief Coaching for Parents of Children With Disabilities in Pediatric Outpatient Clinics

Pilot Study of a Behavioral Program for Resident Depression in Skilled Nursing Facilities

Storytelling and Mindfulness for Graduate Student Wellbeing

Sleep and Light Intervention (SALI) for Menopausal Mood Dysfunction

Psilocybin for Depression in People With Mild Cognitive Impairment or Early Alzheimer's Disease

Cannabis, Linked Emotions, and Adolescent Risk Study

Psilocybin rTMS for Treatment Resistant Depression

M-O-M-S on the Bayou: Implementation of an Intervention for Mental Health in Pregnancy

Study on Allopregnanolone and Depression in Women Across the Menopause Transition

Tele-PROTECT Therapy: Effectiveness, Empowerment, and Implementation

Adaptive Coping Skills Training to Improve Psychological Distress Among Cardiorespiratory Failure Survivors

Facilitated Transitions From Postpartum to Primary Care Coordination for People With Chronic Conditions

Inhibitory Mechanisms of Negative Urgency in Adolescent Suicidal Behavior

Virtual Reality Intervention to Improve Psychological Symptom Burden for Cancer Patients Undergoing Treatment

Dosing rTMS for Depression Post-SCI

Assessing Improvements in Mood and Sleep Trial

Frequently Asked Questions