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depression Clinical Trials in United States

Active clinical trials for depression with research sites in United States. All data sourced live from ClinicalTrials.gov — updated daily.

Active Trials: 33 // Recruiting: 33 Phases: Phase 2, Phase 3, Phase 2 // Updated: Daily
Total Trials
33
Recruiting Now
33
Country
🇺🇸 United States

Active Trials in United States (33)

NCT05474846 Phase 2, Phase 3
Recruiting

Combination Therapy for Treatment of Sleep Disturbance in Patients With Advanced Cancer

Enrollment
188 pts
Country
🇺🇸 United States
M.D. Anderson Cancer Center
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NCT07220486
Recruiting

Behavioral Health Program for Short-Stay Nursing Facility Residents & Care Partners

Enrollment
100 pts
Country
🇺🇸 United States
Massachusetts General Hospital
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NCT05553353
Recruiting

Dosing rTMS for Depression Post-SCI

Enrollment
24 pts
Country
🇺🇸 United States
VA Office of Research and Developme...
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NCT06696001
Recruiting

Neuroscience of Psychotherapy for Depression

Enrollment
45 pts
Country
🇺🇸 United States
University of North Carolina, Chape...
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NCT06039930
Recruiting

Tele-PROTECT Therapy: Effectiveness, Empowerment, and Implementation

Enrollment
140 pts
Country
🇺🇸 United States
Weill Medical College of Cornell Un...
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NCT06326905
Recruiting

CAPABLE Transplant

Enrollment
43 pts
Country
🇺🇸 United States
Johns Hopkins University
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NCT04752618
Recruiting

Safe Mothers, Safe Children Initiative

Enrollment
160 pts
Country
🇺🇸 United States
New York University
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NCT06721559
Recruiting

Empower@Home: Community Implementation for Older Adults With Ambulatory Disabilities

Enrollment
64 pts
Country
🇺🇸 United States
University of Michigan
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NCT05763537
Recruiting

Understanding the Role of Doulas in Supporting People With PMADs

Enrollment
75 pts
Country
🇺🇸 United States
University of Montana
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NCT06725160
Recruiting

Parent Encouragement And Coaching of Happiness in Youth

Enrollment
180 pts
Country
🇺🇸 United States
University of Pittsburgh
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NCT05405803
Recruiting

To Improve Depressive Symptoms Using a Web-App

Enrollment
300 pts
Country
🇺🇸 United States
University of Texas at Austin
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NCT06262178
Recruiting

Parenting STAIR: Adapting a Trauma-Focused Parenting Intervention for Military-Connected Mothers and Their Children

Enrollment
120 pts
Country
🇺🇸 United States
New York University
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NCT02604277
Recruiting

Suicidal Behavior in Patients Diagnosed With Bipolar Disorder

Enrollment
130 pts
Country
🇺🇸 United States
Emory University
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NCT07219875 Phase 2
Recruiting

Training Reward Responsiveness Through Virtual Reality

Enrollment
80 pts
Country
🇺🇸 United States
University of California, Los Angel...
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NCT07346014
Recruiting

Sleep and Circadian Interventions for College Students at High Risk of Suicide

Enrollment
90 pts
Country
🇺🇸 United States
University of Pittsburgh
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NCT03065335 Phase 1
Recruiting

Neuropharmacologic Imaging and Biomarker Assessments of Response to Acute and Repeated-Dosed Ketamine Infusions in Major Depressive Disorder

Enrollment
150 pts
Country
🇺🇸 United States
National Institute of Mental Health...
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NCT04263285
Recruiting

Treatment of Depression Post-SCI

Enrollment
14 pts
Country
🇺🇸 United States
Medical University of South Carolin...
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NCT03388606
Recruiting

Characterization and Treatment of Adolescent Depression

Enrollment
4,100 pts
Country
🇺🇸 United States
National Institute of Mental Health...
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NCT05559749
Recruiting

Collaborative Care for Anxiety and Depression in Epilepsy

Enrollment
60 pts
Country
🇺🇸 United States
Wake Forest University Health Scien...
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NCT06261463
Recruiting

Hybrid Type 1 Randomized Pilot Trial of a Peer-led Family and Social Strengthening Group Intervention for Refugee Families

Enrollment
74 pts
Country
🇺🇸 United States
University of Illinois at Chicago
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NCT07091968
Recruiting

Feasibility of a Technology-Based Intervention for Depression Referral Uptake in Cancer Survivors

Enrollment
60 pts
Country
🇺🇸 United States
Medical University of South Carolin...
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NCT05563805
Recruiting

Exploring Virtual Reality Adventure Training Exergaming

Enrollment
40 pts
Country
🇺🇸 United States
The University of Texas at Arlingto...
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NCT06652503
Recruiting

The Student Wellness and Emotional Growth Resiliency (SWAG-R) Program

Enrollment
160 pts
Country
🇺🇸 United States
Nova Southeastern University
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NCT02543983 Phase 2
Recruiting

Neurobiology of Suicide

Enrollment
325 pts
Country
🇺🇸 United States
National Institute of Mental Health...
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NCT06073886 Phase 2
Recruiting

Personalized Brain Stimulation to Treat Chronic Concussive Symptoms

Enrollment
75 pts
Country
🇺🇸 United States
University of California, Los Angel...
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NCT06400121 Phase 2
Recruiting

Apimostinel + Automated Neurocognitive Training for Depression

Enrollment
150 pts
Country
🇺🇸 United States
Rebecca Price
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NCT05294991
Recruiting

Wellness App for Sleep Disturbance in Hematological Cancer Patients

Enrollment
276 pts
Country
🇺🇸 United States
The University of Texas Health Scie...
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NCT07224165
Recruiting

Developing a Digital Intervention for Adolescent Nonsuicidal Self-injury

Enrollment
80 pts
Country
🇺🇸 United States
Northwestern University
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NCT06263660 Phase 2
Recruiting

Evaluation of a Keto-Like Supplement on Brain Responses to Emotional Stimuli in Depression

Enrollment
75 pts
Country
🇺🇸 United States
Laureate Institute for Brain Resear...
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NCT06419439 Phase 2
Recruiting

Ketamine-assisted Integrative Treatment for Veterans With Chronic Low Back Pain and Comorbid Depression

Enrollment
44 pts
Country
🇺🇸 United States
VA Office of Research and Developme...
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NCT05543083
Recruiting

Cognitive-Behavioral Therapy and Exercise Training in Adolescents At-Risk for Type 2 Diabetes

Enrollment
300 pts
Country
🇺🇸 United States
Colorado State University
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NCT06753123
Recruiting

Be Well at Work-Plus: A Depression and Physical Activity Intervention for Hospital Service Workers (Aim 2)

Enrollment
10 pts
Country
🇺🇸 United States
San Diego State University
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NCT06597695 Phase 1, Phase 2
Recruiting

A Ketamine-assisted Group Therapy Intervention for Spanish-speaking Adults With Depression

Enrollment
10 pts
Country
🇺🇸 United States
Juliana Zambrano, MD, MPH
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Frequently Asked Questions

How many depression clinical trials are active in United States?
There are currently 33 active clinical trials for depression with sites in United States, of which 33 are actively recruiting patients.
How can I join a depression clinical trial in United States?
To join a depression clinical trial in United States, select a recruiting trial below and check the eligibility criteria. Contact the trial's principal investigator or the listed site in United States directly. All trials listed here are sourced from ClinicalTrials.gov, the official U.S. registry of clinical studies.
What phases are depression trials in United States?
Active depression trials in United States span Phase 2, Phase 3, Phase 2, Phase 1, Phase 1, Phase 2. Phase I trials test safety, Phase II test efficacy, and Phase III compare against standard treatments in larger patient populations.
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ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer  ·  Last Reviewed: July 2026  ·  Data Methodology