NCT06496646 Antidepressant Adherence for Depressed Adults in Primary Care
| NCT ID | NCT06496646 |
| Status | Recruiting |
| Phase | — |
| Sponsor | University of Pennsylvania |
| Condition | Depression |
| Study Type | INTERVENTIONAL |
| Enrollment | 525 participants |
| Start Date | 2025-03-19 |
| Primary Completion | 2029-03-31 |
Eligibility & Interventions
Eligibility Fast-Check
Enter your details for a quick preliminary check. This does not replace medical advice.
What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 525 participants in total. It began in 2025-03-19 with a primary completion date of 2029-03-31.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
The goal of this study is to test ways to help people improve their health and manage their medication for depression. This study will measure both medication adherence and depression outcomes.
Eligibility Criteria
Inclusion Criteria: * Penn Medicine primary care outpatients * Clinical diagnosis of major depressive disorder * A score of 10+ on the Patient Health Questionnaire 9 (PHQ-9) * Age 21 to 64 years at the time of study entry * Prescribed an antidepressant by their primary care clinician * Express interest in taking antidepressant medication * Own a cell phone * Capable of using the electronic pill bottle * English-speaking Exclusion Criteria: * Treated with antidepressants in the past 90 days * Pregnant or breastfeeding * An active substance use disorder other than nicotine * A lifetime history of treatment for bipolar disorder or schizophrenia * Hospital admission or emergency department visit for suicidal symptoms in the past year * Lack capacity to provide informed consent * Using antidepressant more than 10 days at baseline assessment
Contact & Investigator
Frequently Asked Questions
Who can join the NCT06496646 clinical trial?
This trial is open to participants of all sexes, aged 21 Years or older, up to 64 Years, studying Depression. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT06496646 currently recruiting?
Yes, NCT06496646 is actively recruiting participants. Contact the research team at marcuss@upenn.edu for enrollment information.
Where is the NCT06496646 trial being conducted?
This trial is being conducted at Philadelphia, United States.
Who is sponsoring the NCT06496646 clinical trial?
NCT06496646 is sponsored by University of Pennsylvania. The trial plans to enroll 525 participants.
Related Trials
Related Intelligence Guides
In-depth guides covering this condition's trials, eligibility, and what to expect.