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Medical Condition
overweight and obesity
Total Trials
10
Recruiting Now
10
Trial Phases
Various
Obesity research has been transformed by the GLP-1 receptor agonist class (semaglutide, tirzepatide), which achieves 15–22% body weight reduction — approaching surgical outcomes — and reduces cardiovascular events in overweight adults. The pipeline now includes amylin analogs, glucose-dependent insulinotropic polypeptide (GIP) agonists, and oral small molecules targeting appetite regulation.
Active trials investigate next-generation GLP-1 combinations, bimagrumab (anti-ActRII for muscle-sparing weight loss), retatrutide, cagrilintide combinations, and gut microbiome modulators. Trials also study weight regain prevention after GLP-1 discontinuation — an emerging clinical challenge.
Obesity trials typically require a BMI ≥30 or ≥27 with weight-related comorbidities; prior bariatric surgery often excludes participants.
Frequently Asked Questions — overweight and obesity Clinical Trials
How many clinical trials are currently recruiting for overweight and obesity?
ClinicalMetric currently tracks 10 actively recruiting clinical trials for overweight and obesity, sourced in real time from ClinicalTrials.gov. The total number of registered studies—including those not yet enrolling or in active follow-up—is 10. Trial availability changes daily as new studies open enrollment and existing ones reach capacity.
What trial phases are available for overweight and obesity?
overweight and obesity research spans multiple clinical trial phases. Phase 1 studies evaluate safety and dosing in small groups, Phase 2 studies assess preliminary efficacy in 100–300 participants, and Phase 3 trials compare the new treatment against the standard of care in 300–3,000+ patients. Phase 4 post-approval studies monitor long-term outcomes in real-world populations.
How do I find out if I qualify for a overweight and obesity clinical trial?
Eligibility criteria for overweight and obesity trials vary by study and typically specify age range, disease stage or severity, prior treatment history, and specific diagnostic or laboratory parameters. Each listing on ClinicalMetric links to the full protocol on ClinicalTrials.gov, where inclusion and exclusion criteria are documented. Contact the sponsoring site's research coordinator directly to confirm your eligibility—your treating physician or specialist can also help identify the most appropriate trial based on your medical history and current treatment status.
Top Sponsors
2 trials
1 trial
1 trial
1 trial
1 trial
Recruiting Clinical Trials
NCT06147973
Recruiting
An Acceptance-Based Healthy Lifestyle Intervention for Diverse Adolescents
Enrollment
148 pts
Location
United States
Sponsor
Drexel University
NCT05726942
Recruiting
Efficacy of mHealth Applications in Weight Management in a Population Affected by Overweight or Obesity
Enrollment
30 pts
Location
United States
Sponsor
San Diego State University
NCT03574103
Recruiting
Chronic Effect of Fasting
Enrollment
45 pts
Location
Brazil
Sponsor
Federal University of Minas Ge...
NCT05798494
Recruiting
PRE-Pregnancy Weight Loss And the Reducing Effect on CHILDhood Overweight - Aarhus
Enrollment
140 pts
Location
Denmark
Sponsor
Ulla Kampmann Opstrup
NCT05796141
Recruiting
Becoming United in Lifestyle Decisions
Enrollment
736 pts
Location
United States
Sponsor
University of Connecticut
NCT05866107
Recruiting
App and Body Fat Scale in the Management of Overweight Patients
Enrollment
204 pts
Location
China
Sponsor
Capital Medical University
NCT06526650
Recruiting
'Ai Pono Cooking Demonstrations
Enrollment
1,780 pts
Location
United States
Sponsor
University of Hawaii
NCT06526273
Recruiting
PILI 'Āina Household
Enrollment
210 pts
Location
United States
Sponsor
University of Hawaii
NCT03561766
Recruiting
Birth Cohort Study of China Medical University
Enrollment
1,000 pts
Location
China
Sponsor
Shengjing Hospital
NCT04583514
Recruiting
Testing the Adipose Expandability Hypothesis In Vivo During Overfeeding
Enrollment
58 pts
Location
United States
Sponsor
Pennington Biomedical Research...
ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer · Last Reviewed: April 2026 · Data Methodology