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post operative pain

Total Trials
10
Recruiting Now
10
Trial Phases
Phase 4, Phase 3

Pain clinical trials span acute procedural pain, chronic musculoskeletal pain, neuropathic pain, and cancer-related pain β€” each requiring distinct trial designs and patient-reported outcome instruments. The regulatory demand for non-opioid alternatives has intensified the search for novel analgesic mechanisms, particularly ion channel targets and neurostimulation approaches.

Active trials evaluate Nav1.7/1.8 blockers, CGRP antagonists for new indications, spinal cord stimulation refinements, virtual reality-based pain management, and patient-specific ketamine infusion protocols. Pain trials increasingly use ecological momentary assessment (EMA) diary approaches over traditional recall-based pain rating scales.

Frequently Asked Questions — post operative pain Clinical Trials

How many clinical trials are currently recruiting for post operative pain?
ClinicalMetric currently tracks 10 actively recruiting clinical trials for post operative pain, sourced in real time from ClinicalTrials.gov. The total number of registered studies—including those not yet enrolling or in active follow-up—is 10. Trial availability changes daily as new studies open enrollment and existing ones reach capacity.
What trial phases are available for post operative pain?
post operative pain research spans Phase 3 (1 trial), Phase 4 (3 trials). Phase 1 studies evaluate safety and dosing in small groups, Phase 2 studies assess preliminary efficacy in 100–300 participants, and Phase 3 trials compare the new treatment against the standard of care in 300–3,000+ patients. Phase 4 post-approval studies monitor long-term outcomes in real-world populations.
How do I find out if I qualify for a post operative pain clinical trial?
Eligibility criteria for post operative pain trials vary by study and typically specify age range, disease stage or severity, prior treatment history, and specific diagnostic or laboratory parameters. Each listing on ClinicalMetric links to the full protocol on ClinicalTrials.gov, where inclusion and exclusion criteria are documented. Contact the sponsoring site's research coordinator directly to confirm your eligibility—your treating physician or specialist can also help identify the most appropriate trial based on your medical history and current treatment status.
Trial Phases
Phase 3
1
Phase 4
3
Top Sponsors
Prisma Health-Upstate 1 trial
Hitit University 1 trial
The Cleveland Clinic 1 trial
Jessa Hospital 1 trial
Medical University of South Carolina 1 trial

Recruiting Clinical Trials

NCT07101250 Phase 4
Recruiting
Preoperative Acetazolamide
Enrollment
100 pts
Location
United States
Sponsor
Prisma Health-Upstate
View Trial →
NCT07546903
Recruiting
Comparison of Analgesic Efficacy of Suprainguinal Fascia Iliaca and Quadro-iliac Blocks in Hip Fracture Surgery
Enrollment
70 pts
Location
Turkey (Türkiye)
Sponsor
Hitit University
View Trial →
NCT07222072 Phase 4
Recruiting
Methadone to Reduce Chronic Opioid Use After Major Spine Surgery: The MEND Pilot Feasibility Study
Enrollment
120 pts
Location
United States
Sponsor
The Cleveland Clinic
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NCT06205875
Recruiting
High Versus Low Dose Serratus Anterior Plane Block After Minimally Invasive Valve Surgery.
Enrollment
100 pts
Location
Belgium
Sponsor
Jessa Hospital
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NCT07226076 Phase 3
Recruiting
Methadone in TKA for Post-op Pain and Opioid Reduction
Enrollment
162 pts
Location
United States
Sponsor
Medical University of South Ca...
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NCT07375576
Recruiting
Outcomes of Pulpotomy and Root Canal Treatment in Teeth With Symptomatic Irreversible Pulpitis
Enrollment
99 pts
Location
Turkey (Türkiye)
Sponsor
Mustafa Kemal University
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NCT06812832 Phase 4
Recruiting
Simethicone as Part of ERAS in Bariatric Surgery Patients
Enrollment
260 pts
Location
United States
Sponsor
Madigan Army Medical Center
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NCT06001502
Recruiting
The Effect of Virtual Reality on Postoperative Pain and Anxiety in Cardiac Surgery.
Enrollment
100 pts
Location
Netherlands
Sponsor
Academisch Medisch Centrum - U...
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NCT06317870
Recruiting
Pericapsular Nerve Block Versus Intrathecal Morphine for Analgesia After Primary Hip Arthroplasty
Enrollment
80 pts
Location
Switzerland
Sponsor
Centre Hospitalier Universitai...
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NCT07094386
Recruiting
Postoperative Analgesia in Patients Undergoing Open Upper Abdominal Surgeries: External Oblique Intercostal Plane Block vs. Quadratus Lumborum Block
Enrollment
80 pts
Location
Egypt
Sponsor
Cairo University
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Related Conditions

analgesia (2) laparoscopic hysterectomy (1) referred pain (1) spinal surgery (1) surgery (1) cardiac disease (1) pulpitis irreversible (1) success rate (1) simethicone (1) bariatric surgery (1) post operative anxiety (1) heart surgery (1)
ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer  ·  Last Reviewed: April 2026  ·  Data Methodology