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post operative pain

Total Trials
10
Recruiting Now
10
Trial Phases
Phase 1, Phase 2, Phase 2, Phase 3

Pain clinical trials span acute procedural pain, chronic musculoskeletal pain, neuropathic pain, and cancer-related pain β€” each requiring distinct trial designs and patient-reported outcome instruments. The regulatory demand for non-opioid alternatives has intensified the search for novel analgesic mechanisms, particularly ion channel targets and neurostimulation approaches.

Active trials evaluate Nav1.7/1.8 blockers, CGRP antagonists for new indications, spinal cord stimulation refinements, virtual reality-based pain management, and patient-specific ketamine infusion protocols. Pain trials increasingly use ecological momentary assessment (EMA) diary approaches over traditional recall-based pain rating scales.

Frequently Asked Questions — post operative pain Clinical Trials

How many clinical trials are currently recruiting for post operative pain?
ClinicalMetric currently tracks 10 actively recruiting clinical trials for post operative pain, sourced in real time from ClinicalTrials.gov. The total number of registered studies—including those not yet enrolling or in active follow-up—is 10. Trial availability changes daily as new studies open enrollment and existing ones reach capacity.
What trial phases are available for post operative pain?
post operative pain research spans Phase 1 (1 trial), Phase 2 (4 trials), Phase 3 (3 trials). Phase 1 studies evaluate safety and dosing in small groups, Phase 2 studies assess preliminary efficacy in 100–300 participants, and Phase 3 trials compare the new treatment against the standard of care in 300–3,000+ patients. Phase 4 post-approval studies monitor long-term outcomes in real-world populations.
How do I find out if I qualify for a post operative pain clinical trial?
Eligibility criteria for post operative pain trials vary by study and typically specify age range, disease stage or severity, prior treatment history, and specific diagnostic or laboratory parameters. Each listing on ClinicalMetric links to the full protocol on ClinicalTrials.gov, where inclusion and exclusion criteria are documented. Contact the sponsoring site's research coordinator directly to confirm your eligibility—your treating physician or specialist can also help identify the most appropriate trial based on your medical history and current treatment status.
Trial Phases
Phase 1
1
Phase 2
4
Phase 3
3
Top Sponsors
University of Texas Southwestern Medical Center 1 trial
Mount Sinai Hospital, Canada 1 trial
Medical University of South Carolina 1 trial
Cumhuriyet University 1 trial
University Health Network, Toronto 1 trial

Recruiting Clinical Trials

NCT06158620 Phase 1, Phase 2
Recruiting
Intra-nasal Ketorolac for Acute Ureteral Stent-associated Pain Following Ureteroscopy for Stone Disease
Enrollment
80 pts
Location
United States
Sponsor
University of Texas Southweste...
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NCT05953766 Phase 2
Recruiting
Presacral Nerve Block Versus Sham Block on Post-operative Pain for Total Laparoscopic Hysterectomy
Enrollment
60 pts
Location
Canada
Sponsor
Mount Sinai Hospital, Canada
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NCT07226076 Phase 3
Recruiting
Methadone in TKA for Post-op Pain and Opioid Reduction
Enrollment
162 pts
Location
United States
Sponsor
Medical University of South Ca...
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NCT06662617
Recruiting
Analgesic Effect of M-TAPA and TAPB on Laparoscopic Cholesistectomy
Enrollment
12 pts
Location
Turkey (Türkiye)
Sponsor
Cumhuriyet University
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NCT06123715 Phase 2
Recruiting
Perioperative Vitamin C to Reduce Persistent Pain After Total Knee Arthroplasty
Enrollment
400 pts
Location
Canada
Sponsor
University Health Network, Tor...
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NCT07434583
Recruiting
Force Sensor Study
Enrollment
100 pts
Location
United States
Sponsor
University of California, San ...
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NCT07210164
Recruiting
Pre-habilitation Within ERAS Protocol for Gynecologic Oncology Surgery: The Pre_ERAS Study
Enrollment
100 pts
Location
Greece
Sponsor
Aristotle University Of Thessa...
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NCT06725862
Recruiting
Caudal Block vs Retrolaminar Block on Analgesic Consumption in Undescended Testis Surgeries
Enrollment
60 pts
Location
Turkey (Türkiye)
Sponsor
Kanuni Sultan Suleyman Trainin...
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NCT06568770 Phase 2, Phase 3
Recruiting
Comparison of EOSP Between Usg Guided S-FICB vs USG Guided PENG Block in Pts Undergoing Femur Fracture Surgery
Enrollment
70 pts
Location
Pakistan
Sponsor
Sahiwal medical college sahiwa...
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NCT07539623 Phase 3
Recruiting
Suzetrigine-enhanced MultimOdal Opioid-sparing THerapy in Cardiac and Bariatric SURGery
Enrollment
235 pts
Location
United States
Sponsor
Icahn School of Medicine at Mo...
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ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer  ·  Last Reviewed: November 2026  ·  Data Methodology