NCT04899635 POWER Myocardial Fatigue Study: a Biomechanical Assessment of Contractility of Human Myocardium
| NCT ID | NCT04899635 |
| Status | Recruiting |
| Phase | — |
| Sponsor | University Hospitals Coventry and Warwickshire NHS Trust |
| Condition | Heart Failure |
| Study Type | OBSERVATIONAL |
| Enrollment | 100 participants |
| Start Date | 2021-08-03 |
| Primary Completion | 2025-04-30 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
This is an observational study. You will not receive an experimental treatment; researchers will collect data based on your existing condition or standard treatment.
This trial targets 100 participants in total. It began in 2021-08-03 with a primary completion date of 2025-04-30.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
To gain a comprehensive understanding of the biomechanical behaviour of human heart to explore the concept of myocardial fatigue in response to a temporal range of preload, afterload and drug-induced inotropy using in-vitro contractile assays.
Eligibility Criteria
Inclusion Criteria: * All adult patients between 18 to 85-years old undergoing open-heart surgery who can undergo the consent process for the study * Healthy donor hearts that are deemed non-transplantable and consent received from a legal representative Exclusion Criteria: This criterion is kept to a minimum since the availability of human myocardial samples is finite and dependent on the limited number of patients undergoing cardiac surgery annually within the local hospital. * Patients who do not have the mental capacity to undergo the consent process * For the safety of researchers, patients with evidence of ongoing blood-borne infections such as HIV, or a recent positive test for COVID-19 (within 10 days of last PCR test).
Contact & Investigator
Frequently Asked Questions
Who can join the NCT04899635 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, up to 85 Years, studying Heart Failure. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT04899635 currently recruiting?
Yes, NCT04899635 is actively recruiting participants. Contact the research team at patricktranphd@gmail.com for enrollment information.
Where is the NCT04899635 trial being conducted?
This trial is being conducted at Coventry, United Kingdom.
Who is sponsoring the NCT04899635 clinical trial?
NCT04899635 is sponsored by University Hospitals Coventry and Warwickshire NHS Trust. The trial plans to enroll 100 participants.
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