Medical Condition

colon cancer

Total Trials

11

Recruiting Now

11

Trial Phases

Phase 1, Phase 2, Phase 3, Phase 1

Colorectal cancer trials are increasingly guided by molecular profiling β€” RAS/BRAF mutation status, microsatellite instability (MSI-H/dMMR), and HER2 amplification now define distinct treatment tracks. MSI-H colorectal cancer has become the poster child for immunotherapy in solid tumors, with pembrolizumab as first-line standard of care, while KRAS G12C inhibitors have opened the door to targeted therapy for previously untreatable RAS-mutant disease.

Active trials include KRAS G12C and G12D inhibitor combinations, anti-EGFR rechallenge guided by liquid biopsy, adagrasib plus cetuximab, liver-directed therapies for oligometastatic disease, and peritoneal hyperthermia chemotherapy (HIPEC) for peritoneal metastasis.

Frequently Asked Questions — colon cancer Clinical Trials

How many clinical trials are currently recruiting for colon cancer?

ClinicalMetric currently tracks 11 actively recruiting clinical trials for colon cancer, sourced in real time from ClinicalTrials.gov. The total number of registered studies—including those not yet enrolling or in active follow-up—is 11. Trial availability changes daily as new studies open enrollment and existing ones reach capacity.

What trial phases are available for colon cancer?

colon cancer research spans Phase 1 (3 trials), Phase 2 (4 trials), Phase 3 (2 trials). Phase 1 studies evaluate safety and dosing in small groups, Phase 2 studies assess preliminary efficacy in 100–300 participants, and Phase 3 trials compare the new treatment against the standard of care in 300–3,000+ patients. Phase 4 post-approval studies monitor long-term outcomes in real-world populations.

How do I find out if I qualify for a colon cancer clinical trial?

Eligibility criteria for colon cancer trials vary by study and typically specify age range, disease stage or severity, prior treatment history, and specific diagnostic or laboratory parameters. Each listing on ClinicalMetric links to the full protocol on ClinicalTrials.gov, where inclusion and exclusion criteria are documented. Contact the sponsoring site's research coordinator directly to confirm your eligibility—your treating physician or specialist can also help identify the most appropriate trial based on your medical history and current treatment status.

Trial Phases

Phase 1

Phase 2

Phase 3

Top Sponsors

Institut du Cancer de Montpellier - Val d'Aurelle 2 trials

Fondazione Policlinico Universitario Agostino Gemelli IRCCS 1 trial

Unity Health Toronto 1 trial

AC Camargo Cancer Center 1 trial

QuantumLeap Healthcare Collaborative 1 trial

Recruiting Clinical Trials

NCT06202131

Recruiting

Use of Ctdna in Patients With Gastrointestinal Tract Tumors

Fondazione Policlinico Univers...

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NCT05257135

Recruiting

A Clinico-biological Database in Cachexia in Patients With Colon Cancer

Institut du Cancer de Montpell...

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NCT07387263

Recruiting

Mainstreaming Genetics: Evaluation of a Digital Application to Scale and Spread Oncologist-initiated Genetic Testing

Study to Evaluate the Use of Surgical Gloves for the Prevention of Oxaliplatin-Induced Peripheral Neuropathy

AC Camargo Cancer Center

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NCT05868226 Phase 1, Phase 2

Recruiting

PRE-ISPY Phase I/II Oncology Platform Program

QuantumLeap Healthcare Collabo...

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NCT06270017 Phase 1, Phase 2

Recruiting

Evaluation of Metastatic Disease and Oncological Treatment in Patients With Colon Cancer Using Zebra Fish Avatars

University Hospital, Linkoepin...

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NCT07098182

Recruiting

Contribution of Preserving the Superior Left Colic Artery to the Vascularization of the Descending Colon Prior to Colorectal Anastomosis During Left-Sided or Rectal Resections for Colorectal or Ovarian Cancer. (Revascularisation Colique)

Institut du Cancer de Montpell...

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NCT05534087 Phase 3

Recruiting

Platform Study of Circulating Tumor DNA Directed Adjuvant Chemotherapy in Colon Cancer (KCSG CO22-12)

Seoul National University Hosp...

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NCT06126406 Phase 1

Recruiting

Clinical Study of CEA Targeting Chimeric Antigen Receptor T Lymphocytes（CAR-T） for CEA Positive Advanced Malignant Solid Tumors

Chongqing Precision Biotech Co...

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NCT07272772 Phase 2, Phase 3

Recruiting

Colon Cancer Diagnosis With FAPI-PET Imaging

Turku University Hospital

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NCT06923787 Phase 2

Recruiting

Effect of Perioperative Intravenous Infusion of Lidocaine on the Postoperative Course and the Immune Response in Patients Undergoing Surgery for Colon Cancer - the PILDI Study

Institute of Oncology Ljubljan...

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Related Conditions

rectal cancer (3) pancreas cancer (2) breast cancer (2) ovarian cancer (2) biliary tract cancer (1) cancer (1) prostate cancer (1) gi cancers (1) pancreatic cancer (1) oxaliplatin induced peripheral neuropathy (1) her2 positive breast cancer (1) metastatic cancer (1)

ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer · Last Reviewed: November 2026 · Data Methodology