Medical Condition

colon cancer

Total Trials

13

Recruiting Now

13

Trial Phases

Phase 1, Phase 2, Phase 1, Phase 2

Colorectal cancer trials are increasingly guided by molecular profiling β€” RAS/BRAF mutation status, microsatellite instability (MSI-H/dMMR), and HER2 amplification now define distinct treatment tracks. MSI-H colorectal cancer has become the poster child for immunotherapy in solid tumors, with pembrolizumab as first-line standard of care, while KRAS G12C inhibitors have opened the door to targeted therapy for previously untreatable RAS-mutant disease.

Active trials include KRAS G12C and G12D inhibitor combinations, anti-EGFR rechallenge guided by liquid biopsy, adagrasib plus cetuximab, liver-directed therapies for oligometastatic disease, and peritoneal hyperthermia chemotherapy (HIPEC) for peritoneal metastasis.

Frequently Asked Questions — colon cancer Clinical Trials

How many clinical trials are currently recruiting for colon cancer?

ClinicalMetric currently tracks 13 actively recruiting clinical trials for colon cancer, sourced in real time from ClinicalTrials.gov. The total number of registered studies—including those not yet enrolling or in active follow-up—is 13. Trial availability changes daily as new studies open enrollment and existing ones reach capacity.

What trial phases are available for colon cancer?

colon cancer research spans Phase 1 (2 trials), Phase 2 (3 trials). Phase 1 studies evaluate safety and dosing in small groups, Phase 2 studies assess preliminary efficacy in 100–300 participants, and Phase 3 trials compare the new treatment against the standard of care in 300–3,000+ patients. Phase 4 post-approval studies monitor long-term outcomes in real-world populations.

How do I find out if I qualify for a colon cancer clinical trial?

Eligibility criteria for colon cancer trials vary by study and typically specify age range, disease stage or severity, prior treatment history, and specific diagnostic or laboratory parameters. Each listing on ClinicalMetric links to the full protocol on ClinicalTrials.gov, where inclusion and exclusion criteria are documented. Contact the sponsoring site's research coordinator directly to confirm your eligibility—your treating physician or specialist can also help identify the most appropriate trial based on your medical history and current treatment status.

Trial Phases

Phase 1

Phase 2

Top Sponsors

University Medical Center Ho Chi Minh City (UMC) 1 trial

Immanuel Kant Baltic Federal University 1 trial

Larissa University Hospital 1 trial

GONGCHU Biotechnology Co., Ltd 1 trial

University of Iowa 1 trial

Recruiting Clinical Trials

NCT07546565

Recruiting

Mechanical Bowel Preparation in Laparoscopic Right Hemicolectomy With Intracorporeal Anastomosis

University Medical Center Ho C...

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NCT06050447

Recruiting

Factors Affecting the Results of Treatment of Patients With Colorectal Cancer

Immanuel Kant Baltic Federal U...

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NCT05713903

Recruiting

Laparoscopic Versus Open Right Colectomy for Right Colon Cancer

Larissa University Hospital

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NCT06508307 Phase 1

Recruiting

A Phase I Clinical Study of Intratumoral Injection Oncolytic Vaccinia Virus GC001 in Patient With Advanced Solid Tumors

GONGCHU Biotechnology Co., Ltd

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NCT05239546 Phase 2

Recruiting

Single Arm Study of Neoadjuvant Dostarlimab in Stage II and III Deficient Mismatch Repair Colon Cancers

Circulating Tumor DNA (ctDNA) for Early Treatment Response Assessment of Solid Tumors

Washington University School o...

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NCT06006390 Phase 1, Phase 2

Recruiting

CEA Targeting Chimeric Antigen Receptor T Lymphocytes (CAR-T) in the Treatment of CEA Positive Advanced Solid Tumors

Chongqing Precision Biotech Co...

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NCT06242418 Phase 2

Recruiting

CtDNA in Adjuvant Chemotherapy of Stage III Colon Cancer (REVISE Trial)

NIMA-Colon Cancer Study

Fundación Pública Andaluza par...

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NCT04907643

Recruiting

Virtual Reality for GI Cancer Pain to Improve Patient Reported Outcomes

Cedars-Sinai Medical Center

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NCT04871399

Recruiting

Complete Mesocolic Excision in Comparison With Conventional Surgery for the Right Colon Cancer

University of Turin, Italy

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NCT04364373

Recruiting

D2 vs D3 Lymph Node Dissection for Left Colon Cancer

Russian Society of Colorectal ...

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NCT06802991

Recruiting

Optimised Post-discharge Care in Older Patients After Surgery for Colon Cancer (ERAS 3.0)

Copenhagen University Hospital...

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Related Conditions

rectal cancer (3) lung cancer (3) breast cancer (3) sarcoma (2) gastric cancer (2) esophageal cancer (2) pancreas cancer (2) colorectal cancer (1) colorectal adenocarcinoma (1) colorectal neoplasms malignant (1) rectal adenocarcinoma (1) cervical cancer (1)

ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer · Last Reviewed: July 2026 · Data Methodology