Medical Condition

colon cancer

Total Trials

17

Recruiting Now

17

Trial Phases

Phase 1, Phase 2, Phase 3, Phase 2

Colorectal cancer trials are increasingly guided by molecular profiling β€” RAS/BRAF mutation status, microsatellite instability (MSI-H/dMMR), and HER2 amplification now define distinct treatment tracks. MSI-H colorectal cancer has become the poster child for immunotherapy in solid tumors, with pembrolizumab as first-line standard of care, while KRAS G12C inhibitors have opened the door to targeted therapy for previously untreatable RAS-mutant disease.

Active trials include KRAS G12C and G12D inhibitor combinations, anti-EGFR rechallenge guided by liquid biopsy, adagrasib plus cetuximab, liver-directed therapies for oligometastatic disease, and peritoneal hyperthermia chemotherapy (HIPEC) for peritoneal metastasis.

Frequently Asked Questions — colon cancer Clinical Trials

How many clinical trials are currently recruiting for colon cancer?

ClinicalMetric currently tracks 17 actively recruiting clinical trials for colon cancer, sourced in real time from ClinicalTrials.gov. The total number of registered studies—including those not yet enrolling or in active follow-up—is 17. Trial availability changes daily as new studies open enrollment and existing ones reach capacity.

What trial phases are available for colon cancer?

colon cancer research spans Phase 1 (2 trials), Phase 2 (3 trials), Phase 3 (1 trial). Phase 1 studies evaluate safety and dosing in small groups, Phase 2 studies assess preliminary efficacy in 100–300 participants, and Phase 3 trials compare the new treatment against the standard of care in 300–3,000+ patients. Phase 4 post-approval studies monitor long-term outcomes in real-world populations.

How do I find out if I qualify for a colon cancer clinical trial?

Eligibility criteria for colon cancer trials vary by study and typically specify age range, disease stage or severity, prior treatment history, and specific diagnostic or laboratory parameters. Each listing on ClinicalMetric links to the full protocol on ClinicalTrials.gov, where inclusion and exclusion criteria are documented. Contact the sponsoring site's research coordinator directly to confirm your eligibility—your treating physician or specialist can also help identify the most appropriate trial based on your medical history and current treatment status.

Trial Phases

Phase 1

Phase 2

Phase 3

Top Sponsors

Institute of Oncology Ljubljana 2 trials

Meander Medical Center 1 trial

QuantumLeap Healthcare Collaborative 1 trial

Technische Universität Dresden 1 trial

European Organisation for Research and Treatment of Cancer - EORTC 1 trial

colon cancer

Frequently Asked Questions — colon cancer Clinical Trials

Recruiting Clinical Trials

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